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  1. 4301
    “…Methods described here contribute to minimize PBMC donor variability while reducing costs, streamlining assay setup and convenience and laying the foundations for harmonization of biological reagents usage in standardized immunopotency assays for MSC. …”
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    Optimized reagents for immunopotency assays on mesenchymal stromal cells for clinical use
  2. 4302
    “…RESULTS: Here, we present scRNASequest, a semi-automated single-cell RNA-seq (scRNA-seq) data analysis workflow which allows (1) preprocessing from raw UMI count data, (2) harmonization by one or multiple methods, (3) reference-dataset-based cell type label transfer and embedding projection, (4) multi-sample, multi-condition single-cell level differential gene expression analysis, and (5) seamless integration with cellxgene VIP for visualization and with CellDepot for data hosting and sharing by generating compatible h5ad files. …”
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    scRNASequest: an ecosystem of scRNA-seq analysis, visualization, and publishing
  3. 4303
    “…CONCLUSION: The identified data elements and development of the technological platform establishes a data infrastructure that facilitates the standardization and harmonization of data as well as perform high performance analytics needed to fully leverage the captured patient-generated data, clinical evidence, and other healthcare ecosystem data within the TMJ/TMD-CRN.…”
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    Building the foundation for a modern patient-partnered infrastructure to study temporomandibular disorders
  4. 4304
    “…We anticipate that harmonization of protocols across centres and advances in standardization will facilitate the clinical establishment of misfolded α-syn detection by RT-QuIC.…”
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    Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis
  5. 4305
    “…The method was validated in accordance with the United States Food and Drug Administration (US FDA), European Medicines Agency (EMA), and the International Committee of Harmonization Multidisciplinary (ICH M10) guidelines, and parameters such as precision, accuracy, dilutional linearity, assay range, robustness, and stability were assessed. …”
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    Multiplexed bead-based assay for the simultaneous quantification of human serum IgG antibodies to tetanus, diphtheria, pertussis toxin, filamentous hemagglutinin, and pertactin
  6. 4306
    “…Scalable tools for rapid and reproducible data analysis facilitate multicenter data integration and harmonization. Clinicians use intracranial EEG (iEEG) in conjunction with non-invasive brain imaging to identify epileptic networks and target therapy for drug-resistant epilepsy cases. …”
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    iEEG-recon: A Fast and Scalable Pipeline for Accurate Reconstruction of Intracranial Electrodes and Implantable Devices
  7. 4307
    “…The suggested technique was validated with respect to the International Council of Harmonization (ICH) recommendations. The suggested technique was found to be simpler and greener with lower cost compared to the earlier reported methods which required complicated techniques, longer time of analysis, and less safe solvents and reagents. …”
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    Green Constant-wavelength Concurrent Selective Fluorescence Method for Assay of Ibuprofen and Chlorzoxazone in Presence of Chlorzoxazone Degradation Product
  8. 4308
    “…Future research is warranted to better understand which scanner properties influence the tissue segmentation process and to develop harmonization techniques for comparing data across multiple slide scanners.…”
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    Whole slide imaging (WSI) scanner differences influence optical and computed properties of digitized prostate cancer histology
  9. 4309
    “…Comparable data were harmonized and each of the CVH metrics was scored using AHA guidelines as high (2), moderate (1), or low (0) to create total CVH scores with higher scores representing better CVH. …”
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    Comparison of cardiovascular health profiles across population surveys from five high- to low-income countries
  10. 4310
    “…However, for inter-laboratory harmonization, the proper conversion factor according to the CML international standard (IS) has to be reevaluated each time the grade of RT is changed.…”
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    Reverse Transcription Can Critically Impact the Diagnostic Outcome of BCR::ABL1 Quantitative Real-Time RT-PCR
  11. 4311
    por El-Maraghy, Christine Maged
    Publicado 2023
    “…Following the International Conference on Harmonization (ICH) guidelines, the methods were found to be accurate, precise, and selective. …”
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    Sustainable eco-friendly ratio-based spectrophotometric and HPTLC-densitometric methods for simultaneous analysis of co-formulated anti-migraine drugs with overlapped spectra
  12. 4312
    por Aja-Fernández, Santiago, Martín-Martín, Carmen, Planchuelo-Gómez, Álvaro, Faiyaz, Abrar, Uddin, Md Nasir, Schifitto, Giovanni, Tiwari, Abhishek, Shigwan, Saurabh J., Kumar Singh, Rajeev, Zheng, Tianshu, Cao, Zuozhen, Wu, Dan, Blumberg, Stefano B., Sen, Snigdha, Goodwin-Allcock, Tobias, Slator, Paddy J., Yigit Avci, Mehmet, Li, Zihan, Bilgic, Berkin, Tian, Qiyuan, Wang, Xinyi, Tang, Zihao, Cabezas, Mariano, Rauland, Amelie, Merhof, Dorit, Manzano Maria, Renata, Campos, Vinícius Paraníba, Santini, Tales, da Costa Vieira, Marcelo Andrade, HashemizadehKolowri, SeyyedKazem, DiBella, Edward, Peng, Chenxu, Shen, Zhimin, Chen, Zan, Ullah, Irfan, Mani, Merry, Abdolmotalleby, Hesam, Eckstrom, Samuel, Baete, Steven H., Filipiak, Patryk, Dong, Tanxin, Fan, Qiuyun, de Luis-García, Rodrigo, Tristán-Vega, Antonio, Pieciak, Tomasz
    Publicado 2023
    “…In conclusion, extreme caution should be exercised when using AI methods for harmonization or synthesis in clinical studies when processing heterogeneous data in clinical studies, as important information may be altered, even when global metrics such as structural similarity or peak signal-to-noise ratio appear to suggest otherwise.…”
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    Validation of deep learning techniques for quality augmentation in diffusion MRI for clinical studies
  13. 4313
    “…The primary outcome was PSCI at 3–6 months, defined as an adjusted z-score of less than − 2.0 standard deviation in at least one of the four cognitive domains (memory, executive/frontal, visuospatial, and language), using the Korean version of the Vascular Cognitive Impairment Harmonization Standards-Neuropsychological Protocol (VCIHS-NP). …”
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    Prediction of post-stroke cognitive impairment after acute ischemic stroke using machine learning
  14. 4314
    “…HIGHLIGHTS: A novel stability-indicating assay method was developed and fully validated according to the International Council on Harmonization (Q2) R1 for the analysis of FLB in the pharmaceutical preparations. …”
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    A Different Perspective on the Characterization of a New Degradation Product of Flibanserin With HPLC–DAD–ESI-IT-TOF-MS(n) and Its Pharmaceutical Formulation Analysis With Inter-Laboratory Comparison
  15. 4315
    por Endomba, F. T., Tariku, M.
    Publicado 2023
    “…This review draws health professionals’ attention caring people with schizophrenia, and calls for further studies with a harmonization of screening tool, a better representativity of some subregions, and the assessment of key potential factors such as perceived stigma and self-stigma. …”
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    Epidemiology of depression in schizophrenia patients living in Africa: a systematic review and meta-analysis
  16. 4316
    “…Here we describe the proteomic landscape of cerebrospinal fluid (CSF) changes associated with Aβ and tau pathology in 300 individuals as assessed by two different proteomic technologies—tandem mass tag (TMT) mass spectrometry and SomaScan. Harmonization and integration of both data types allowed for generation of a robust protein co-expression network consisting of 34 modules derived from 5242 protein measurements, including disease-relevant modules associated with autophagy, ubiquitination, endocytosis, and glycolysis. …”
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    Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
  17. 4317
    “…This review will provide a systematic assessment of the literature on methods for the clinical validation of digital endpoints and highlight any potential need for harmonization or reporting of methods. The results will include the methods for the clinical validation of digital endpoints according to device, digital endpoint, and clinical application goal of digital endpoints. …”
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    Methods for the Clinical Validation of Digital Endpoints: Protocol for a Scoping Review Abstract
  18. 4318
    “…Although the AHTUS offers the most comprehensive attempt at harmonization yet undertaken with these individual time-use surveys, we found that any noted cross-time changes in walking and physical activity behaviour are not easily interpreted in terms of conventional epidemiological approaches and could be true changes, artefact related to instrument and method changes, or both. …”
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    Walking behaviours from the 1965–2003 American Heritage Time Use Study (AHTUS)
  19. 4319
    “…An overview of existing studies and their data is needed to improve collaboration, harmonization, and future project planning. Objectives: Our goal was to create a comprehensive overview of European birth cohorts with environmental exposure data. …”
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    European Birth Cohorts for Environmental Health Research
  20. 4320
    por Jensen, Richard A., Sim, Xueling, Li, Xiaohui, Cotch, Mary Frances, Ikram, M. Kamran, Holliday, Elizabeth G., Eiriksdottir, Gudny, Harris, Tamara B., Jonasson, Fridbert, Klein, Barbara E. K., Launer, Lenore J., Smith, Albert Vernon, Boerwinkle, Eric, Cheung, Ning, Hewitt, Alex W., Liew, Gerald, Mitchell, Paul, Wang, Jie Jin, Attia, John, Scott, Rodney, Glazer, Nicole L., Lumley, Thomas, McKnight, Barbara, Psaty, Bruce M., Taylor, Kent, Hofman, Albert, de Jong, Paulus T. V. M., Rivadeneira, Fernando, Uitterlinden, Andre G., Tay, Wan-Ting, Teo, Yik Ying, Seielstad, Mark, Liu, Jianjun, Cheng, Ching-Yu, Saw, Seang-Mei, Aung, Tin, Ganesh, Santhi K., O'Donnell, Christopher J., Nalls, Mike A., Wiggins, Kerri L., Kuo, Jane Z., van Duijn, Cornelia M., Gudnason, Vilmundur, Klein, Ronald, Siscovick, David S., Rotter, Jerome I., Tai, E. Shong, Vingerling, Johannes, Wong, Tien Y.
    Publicado 2013
    “…METHODS: A working group agreed on phenotype harmonization, covariate selection and analytic plans for within-cohort GWAS. …”
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    Genome-Wide Association Study of Retinopathy in Individuals without Diabetes
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