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121por Livermore, Catherine, Simon, Michelle, Reeves, Richard, Stévant, Isabelle, Nef, Serge, Pope, Madeleine, Mallon, Ann-Marie, Wells, Sara, Warr, Nick, Greenfield, Andy“…Here. we show that a B6.Y(POS) colony bred and archived at the MRC Harwell Institute lacks the chromosome 11 modifier but instead harbors an ∼37 Mb region containing non-B6-derived segments on chromosome 13. …”
Publicado 2020
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122“…Methods: To investigate the ultrasonic environment in a large mouse breeding facility (the Mary Lyon Centre at MRC Harwell), we compared two systems, the Hottinger Bruel and Kjaer PULSE sound analyser, and an Avisoft Bioacoustics system. …”
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123por da Cunha Sousa, Larissa Fonseca, Coelho, Fernanda Matos, Rodrigues, David Henrique, Campos, Alline Cristina, da Silva Barcelos, Lucíola, Teixeira, Mauro Martins, Alvarenga Rachid, Milene, Teixeira, Antonio Lúcio“…Twenty-four hours after the reperfusion procedure, behavioral changes, including motor signs, were analyzed with the SmithKline/Harwell/Imperial College/Royal Hospital/Phenotype Assessment (SHIRPA) battery. …”
Publicado 2013
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124por Zhang, Youming, Dean, Charlotte, Chessum, Lauren, Nguyen, Dao, Stewart, Michelle, Taylor, Martin, Cookson, William O., Moffatt, Miriam F.“…All five exons encoding the PHD domain of Phf11 were directly sequenced in 3840 mouse DNA samples from the UK MRC Harwell ENU (N-ethyl-N-nitrosourea)-mutagenised DNA archive. …”
Publicado 2014
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125por H. Khan, M. Anwar, Morris, William C., Galloway, Matthew, A. Shallcross, Beth M., Percival, Carl J., Shallcross, Dudley E.“…Levels of the stabilized Criegee Intermediate (sCI), produced via the ozonolysis of unsaturated volatile organic compounds (VOCs), were estimated at two London urban sites (Marylebone Road and Eltham) and one rural site (Harwell) in the UK over the period of 1998–2012. The steady‐state approximation was applied to data obtained from the NETCEN (National Environmental Technology Centre) database, and the levels of annual average sCI were estimated to be in the range of 30–3000 molecules cm(−3) for UK sites. …”
Publicado 2017
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126por Zhang, Youming, Poobalasingam, Thanushiyan, Yates, Laura L., Walker, Simone A., Taylor, Martin S., Chessum, Lauren, Harrison, Jackie, Tsaprouni, Loukia, Adcock, Ian M., Lloyd, Clare M., Cookson, William O., Moffatt, Miriam F., Dean, Charlotte H.“…Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear. Using the MRC Harwell N-ethyl-N-nitrosourea (ENU) DNA archive, we identified a point mutation in Dpp10 that caused an amino acid change from valine to aspartic acid in the β-propeller region of the protein. …”
Publicado 2018
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127por Kubinyecz, Oana, Vikhe, Pratik P., Purnell, Thomas, Brown, Steve D. M., Tateossian, Hilda“…The mouse mutant Jeff is a single gene mouse model for OM identified from a deafness screen as part of an ENU mutagenesis program at MRC Harwell. Jeff carries a missense mutation in the Fbxo11 gene. …”
Publicado 2020
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