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  1. 7081
    “…The functional effect of the candidate canine IBA57 pathogenic variant was biochemically examined in an established HeLa cell culture model in which the endogenous IBA75 gene product was depleted by RNAi. …”
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    A novel IBA57 variant is associated with mitochondrial iron–sulfur protein deficiency and necrotizing myelopathy in dogs
  2. 7082
    “…The metal complexes had moderated anticancer potencies, with NTZ-Cu(II) having IC(50) values of 24.5 and 21.5 against human breast cancer cells (MCF-7) and cancerous cervical tumor cells (HeLa), respectively. All obtained complexes exhibited high selectivity. …”
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    Investigating the Biological Potency of Nitazoxanide-Based Cu(II), Ni(II) and Zn(II) Complexes Synthesis, Characterization and Anti-COVID-19, Antioxidant, Antibacterial and Anticancer Activities
  3. 7083
    “…MCF-7 (ER + ve), MDA-MB-231 (ER-ve), HeLa (cervical cancer), and Ishikawa (endometrial cancer). …”
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    Natural product-inspired synthesis of coumarin–chalcone hybrids as potential anti-breast cancer agents
  4. 7084
    “…Comparative cytotoxicity studies revealed that CdSe NCs were more toxic to all three cell lines (HEK-293, MCF-7, and HeLa) than CdSe@CdS core–shell structures. Furthermore, a decrease in mitochondrial membrane potential and intracellular ROS production supported NCs inducing oxidative stress, which led to apoptosis via the mitochondria-mediated pathway. …”
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    Divergent Responses of Hydrophilic CdSe and CdSe@CdS Core–Shell Nanocrystals in Apoptosis and In Vitro Cancer Cell Imaging: A Comparative Analysis
  5. 7085
    “…We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. …”
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    Defining the condensate landscape of fusion oncoproteins
  6. 7086
    “…Its depletion by RNA interference causes HeLa cells to arrest in mitosis. Most chromosomes bi-orient on a metaphase plate, but precocious loss of centromeric cohesin from chromosomes is accompanied by loss of all sister chromatid cohesion, the departure of individual chromatids from the metaphase plate, and a permanent cell cycle arrest, presumably due to activation of the spindle checkpoint. …”
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    Shugoshin Prevents Dissociation of Cohesin from Centromeres During Mitosis in Vertebrate Cells
  7. 7087
    “…It consists of 29 time-lapse image sequences from HeLa, U2OS, and hTERT RPE-1 cells under different experimental conditions, acquired by differential interference contrast microscopy, for a total of 237.9 hours. …”
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    ALFI: Cell cycle phenotype annotations of label-free time-lapse imaging data from cultured human cells
  8. 7088
    “…Effects of extract on colorectal (HCT‐116) and cervical (HeLa) cancer cells viability was determined using MTT test in concentration range: 1–500 μg/mL after 24 and 72 h. …”
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    Anticancer assessment and antibiofilm potential of Laetiporus sulphureus mushroom originated from Serbia
  9. 7089
    “…We solved a crystal structure of the proximal dimerization domain, and show that its disruption compromises endocytosis in HeLa cells, emphasizing the importance of Myo6 dimerization. …”
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    How myosin VI traps its off-state, is activated and dimerizes
  10. 7090
    “…Our findings indicate that both anticancer conjugates were effective against different cancer cell lines, including MCF-7, C33A, and HeLa. Moreover, these conjugates were found to have antioxidant and antibacterial effects as well as reduced hemolytic activity. …”
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    Development and pharmaceutical investigation of novel cervical cancer-targeting and redox-responsive melittin conjugates
  11. 7091
    “…METHODS: The ELK4 levels in human tissue (65 HPV(+) CC tissue and 25 HPV(−) normal cervical tissue) and cell lines (human cervical epithelial immortalized cell line H8 and CC cell lines HeLa [HPV18], CaSki [HPV16], and SiHa [HPV(−)]) were quantified using qRT-PCR and western blot assay. …”
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    ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis
  12. 7092
    “…We found that the cholesterol precursor and EBP-product lathosterol accumulates in both RAB18-null HeLa cells and RAB3GAP1-null fibroblasts derived from an affected individual. …”
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    Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis
  13. 7093
    “…Whole‐exome sequencing was performed on the proband, and Sanger sequencing was performed on some family members. HeLa cell lines and mouse primary cortical neurons were used for immunofluorescence (IF) and reverse transcription‐PCR (RT‐PCR). …”
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    A novel autosomal dominant ERLIN2 variant activates endoplasmic reticulum stress in a Chinese HSP family
  14. 7094
    “…We performed Cell Counting Kit-8, wound-healing, Transwell, and flow cytometry assays to measure proliferation, migration, invasion, and apoptosis, respectively, using the SiHa and HeLa cell lines transfected with APOBEC3A. BALB/c nude mice were used to investigate the effects of APOBEC3A in vivo. …”
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    APOBEC3A suppresses cervical cancer via apoptosis
  15. 7095
    “…In vitro cytotoxicity in HeLa and HEK293T cell lines was evaluated using MTT assays. …”
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    Antimalarial activity of Toona ciliata MJ Roem aqueous methanolic leaf extract and its antioxidant and phytochemical properties
  16. 7096
    “…Experimental approach: Various PKCs fused with green fluorescent protein (PKC-GFP) or other GFP-fused proteins were expressed in HeLa cells, and their propofol-induced dynamics were observed using confocal laser scanning microscopy. …”
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    Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells
  17. 7097
    “…All the antibodies positively detected p16 from the HeLa lysates in western blot except 133A6G5. Studies using immunoprecipitation showed 133A6G5, specifically detected p16. …”
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    Development and Evaluation of p16 based Double Antibody Sandwich ELISA for Detection of Cervical Precancer and Cancer
  18. 7098
    por Cheng, Norton, Trejo, JoAnn
    Publicado 2023
    “…To identify specific deubiquitinating enzymes (DUBs) that control GPCR-p38 mitogen-activated protein kinase signaling, we conducted a siRNA library screen targeting 96 DUBs in endothelial cells and HeLa cells. We identified nine DUBs and validated the function two DUBs including cylindromatosis and ubiquitin-specific protease-34 that specifically regulate thrombin-induced p38 phosphorylation. …”
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    An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses
  19. 7099
    “…Tissue extracts were then screened for activities on androgen receptors (ARs) and estrogen receptors (ER-α and ER-β) using a reporter gene bio-assay based on a HeLa human cell line. Mussel extracts alone did not exhibit AR activity, but in the presence of the reference androgenic hormone dihydrotestosterone (DHT), activities were up to 340% higher than those observed for DHT alone. …”
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    Androgenic and Estrogenic Response of Green Mussel Extracts from Singapore’s Coastal Environment Using a Human Cell-Based Bioassay
  20. 7100
    “…We have applied the proposed method to yeast cell cycling and human HeLa cell cycling and have discovered most of the underlying time-delayed regulations that are supported by multiple lines of experimental evidence and that are remarkably consistent with the current knowledge on phase characteristics for the cell cyclings. …”
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    Discovery of time-delayed gene regulatory networks based on temporal gene expression profiling
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