“…SKA2 has recently been identified in HeLa S3 cells as part of a complex, which is critical for spindle checkpoint silencing and exit from mitosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is hemolytic for sheep red blood cells and cytotoxic for HeLa cells. In artificial diphytanoyl phosphatidylcholine membranes, Delta and Beta toxin formed channels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Nude mice were subcutaneously inoculated with 5 × 10(6 )HeLa cells in both lower limbs. When tumor volume approximated 200 mm(3 )treatment was initiated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Either method of solubilization was equally effective in inhibiting dose-dependent HeLa cell proliferation in culture. The maximum concentration of curcuminoids achieved in serum was at least 100-fold higher than that required for inhibiting cell proliferation in culture and 1000-fold higher than the concentration that has been reported to prevent amyloid plaque formation associated with Alzheimer disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The top, validated compounds, i.e. 6-hydroxy-DL-DOPA, Reactive Blue 2 and myricetin, were shown to inhibit AP site cleavage activity of whole cell protein extracts from HEK 293T and HeLa cell lines, and to enhance the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Consistent with the previous results, expression of the M. leonina TRIMCyp in HeLa-T4 cells rendered the cells resistant to HIV-2(ROD )but not to SIVmac239 infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further, binding studies using S10 extract from HeLa cells, partially silenced for PTB gene expression, resulted in reduced binding by other trans-acting factors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The availability of pathogen and host omics data in an integrated framework allows global analysis of the data and comparisons across different experiments and organisms, as illustrated in several case studies presented here. (1) The identification of a hypothetical protein with differential gene and protein expressions in two host systems (mouse macrophage and human HeLa cells) infected by different bacterial (Bacillus anthracis and Salmonella typhimurium) and viral (orthopox) pathogens suggesting that this protein can be prioritized for additional analysis and functional characterization. (2) The analysis of a vaccinia-human protein interaction network supplemented with protein accumulation levels led to the identification of human Keratin, type II cytoskeletal 4 protein as a potential therapeutic target. (3) Comparison of complete genomes from pathogenic variants coupled with experimental information on complete proteomes allowed the identification and prioritization of ten potential diagnostic targets from Bacillus anthracis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…More importantly, addition of Blom7α to HeLa nuclear extracts increased splicing activity in a dose-dependent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mathematical modeling predicted desensitization of GnRH effects on [Ca(2+)](i) and that desensitization would increase with dose, frequency, and receptor number, but no such desensitization was seen in HeLa and/or LβT2 cells possibly because pulsatile GnRH did not reduce receptor expression (measured by immunofluorescence). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we report that increased levels of IFI16 protein in normal HDFs and in HeLa cells negatively regulate the expression of human telomerase reverse transcriptase (hTERT) gene. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: MAA potentiates 17β-estradiol (E(2)) stimulation of an estrogen-responsive reporter plasmid in HeLa cells transiently transfected with either a human ERα or ERβ expression vector containing a cytomegalovirus (CMV) promoter. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistic studies suggest that EF24 targets the FA pathway through inhibition of the NF-kB pathway kinase IKK. In HeLa cells, nanomolar concentrations of EF24 inhibited hydroxyurea (HU)-induced FANCD2-Ub and foci in a cell-cycle independent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutation of Ser-282 and Ser-559 to alanine (S282A, S559A) resulted in ligand independent activation of ERα as determined by both ERE-driven reporter gene assays and endogenous pS2 gene expression in transiently transfected HeLa cells. Mutation of Ser-46/47 or Ser-294 to alanine markedly reduced estradiol dependent reporter activation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Experimentally, rapid sampling of mitochondrial permeabilisation and effector caspase activity in individual HeLa cervical cancer cells confirmed predictions of the reaction-diffusion model and demonstrated that the signalling network of apoptosis execution could efficiently translate spatial anisotropies in mitochondrial permeabilisation into a homogeneous effector caspase response throughout the cytosol. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…U2OS osteosarcoma cells displayed a limited senescence response with increased expression of DNA damage response markers, whereas HeLa cervical carcinoma cells underwent cell death by apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…By quantitative fluorescence microscopy analysis, we demonstrate that soluble EGFP-LC3 is indeed enriched in the nucleus relative to the cytoplasm in two commonly studied cell lines, COS-7 and HeLa. Although LC3 contains a putative nuclear export signal (NES), inhibition of active nuclear export or mutation of the NES had no effect on the nucleo-cytoplasmic distribution of EGFP-LC3. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODOLOGY/PRINCIPAL FINDINGS: We report here the use of in vivo imaging data obtained by spinning-disk confocal microscopy to study the formation of clathrin-coated structures at the plasma membranes of BSC1 and HeLa cells depleted by RNAi of the clathrin adaptor, AP-2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This provides the relative phosphorylation activities of digested peptides at each of five time points after stimulating HeLa cells with epidermal growth factor (EGF). We initially calculated the correlations between the phosphorylation dynamics patterns of every pair of peptides and connected the strongly correlated pairs to construct a network. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, F.E exhibited 50% inhibitory concentration (IC(50)) of 37.7 μg/ml on the viability of ‘HeLa cells’ using cytotoxicity MTT assay. Subsequently, F.E was fractionated using phase-partitioning with n-hexane, ethyl acetate, and n-butanol. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso