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  1. 7881
    “…This effect was documented in vitro in SH-SY5Y and HeLa cells as well as in primary cultures of hippocampal neurons. …”
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    Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation
  2. 7882
    “…HR was inhibited by overexpression of the forkhead-associated (FHA) domain-mutated NBS1 (G27D/R28D: FHA-2D) protein in HeLa cells or in hamster cells carrying a human X-chromosome. …”
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    Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination
  3. 7883
    “…Here, we showed that several animal isolates of K. oxytoca, including the clinical isolates, produced secreted products in bacterial culture supernatant that display cytotoxicity on HEp-2 and HeLa cells, indicating the ability to produce cytotoxin. …”
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    Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals
  4. 7884
    por So, Eui Young, Ouchi, Toru
    Publicado 2014
    “…Interestingly, glucose uptake and production of mitochondrial ROS (reactive oxygen species) are highly increased in BRAT1 knockdown HeLa cells. Furthermore, both basal and induced activity of Akt and Erk kinases were suppressed in these cells, implicating abnormality in signaling cascades for cellular growth. …”
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    BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction
  5. 7885
    “…Potent cytotoxic activities, especially against HeLa cell line; with LD(50) of 32 μg/ml, BJAB cell line; with LD(50) of 57 μg/ml, and Caco-2 cell line; with LD(50) of 61 μg/ml, were observed. …”
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    Antioxidant, antimicrobial and antiproliferative activities of Anthemis palestina essential oil
  6. 7886
    “…The extracts were tested for its effect on proliferation of cancer cells (MTT assay on HeLa, ZR751 and HepG2). Extract that showed the maximum growth inhibitory effect was subjected for mechanism of action study. …”
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    Cephalotaxus griffithii Hook.f. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells
  7. 7887
    “…We found that SP induced the expression of IL-α in both normal and neoplastic cervical tissue explants. Employing HeLa (adenocarcinoma) cell line as a model system we identified PGE(2) and EGF as possible ligands responsible for SP-mediated induction of IL-1α in these neoplastic cells. …”
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    Seminal plasma induces the expression of IL-1α in normal and neoplastic cervical cells via EP2/EGFR/PI3K/AKT pathway
  8. 7888
    “…CONCLUSION: Our results showed that 2-24a/Cu efficiently generates oxidative stress and down-regulates HSP90AA1 and its client proteins (PIM1, AKT1) in U2os and HeLa cells. These results demonstrate the potential application of this novel copper complex in cancer therapy.…”
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    A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells
  9. 7889
    “…The study also tested the in vitro chemotherapeutic potential of harmalol in HeLa, MDA-MB-231, A549, and HepG2 cell line by MTT assay. …”
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    Sequence Specific Binding of Beta Carboline Alkaloid Harmalol with Deoxyribonucleotides: Binding Heterogeneity, Conformational, Thermodynamic and Cytotoxic Aspects
  10. 7890
    “…To determine whether it can detect the oncogenic activity of cellular DNA derived from four human tumor-cell lines (HeLa, A549, HT-1080, and CEM), DNA (100 µg) was inoculated into newborn CD3 epsilon mice both in the presence of 1 µg of linear pMSV-T24-H-ras/MSV-c-myc as positive control and in its absence. …”
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    A Mouse Strain Defective in Both T Cells and NK Cells Has Enhanced Sensitivity to Tumor Induction by Plasmid DNA Expressing Both Activated H-Ras and c-Myc
  11. 7891
    “…The extract revealed higher cytotoxic activity towards the HL-60 cells (IC(50) 110 μg/ml) than HeLa (IC(50) 300 μg/ml). CONCLUSIONS: The shoots of R. idaeus stand out as a valuable source of sanguiin H-6 and ellagic acid and possess a number of biological properties including antioxidative, antimicrobial and cytotoxic.…”
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    Chemical composition and biological activity of Rubus idaeus shoots – a traditional herbal remedy of Eastern Europe
  12. 7892
    por Ajiro, Masahiko, Zheng, Zhi-Ming
    Publicado 2015
    “…HPV18 E6^E7 is detectable in HPV18-positive HeLa cells and HPV18-infected raft tissues. All together, our data indicate that viral E6^E7 and cellular GRP78 or HSP90 might be novel targets for cervical cancer therapy.…”
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    E6^E7, a Novel Splice Isoform Protein of Human Papillomavirus 16, Stabilizes Viral E6 and E7 Oncoproteins via HSP90 and GRP78
  13. 7893
    “…Cell cycle-dependent phosphorylation of SAMHD1 was examined in synchronised HeLa cells and using recombinant SAMHD1. SAMHD1 was knocked down by RNA interference. …”
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    SAMHD1 prevents autoimmunity by maintaining genome stability
  14. 7894
    “…These histones were FLAG-tagged in HeLa cells and purified using chromatin immunoprecipitation (ChIP). …”
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    Proteogenomics analysis reveals specific genomic orientations of distal regulatory regions composed by non-canonical histone variants
  15. 7895
    “…In vitro transcribed red fluorescent protein (RFP)/Hepatitis B virus surface antigen (HBsAg) RNA, fused to 5′-HEV sequence with cap and encapsidation signal (1–249 nt), was packaged into the recombinant HEV-VLPs and incubated with five different cell lines (Huh7, A549, Vero, HeLa and SiHa). The pORF2-VLPs could specifically transfer exogenous coding RNA into Huh7 and A549 cells. …”
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    Recombinant Hepatitis E virus like particles can function as RNA nanocarriers
  16. 7896
    “…Transfection was performed by the modified calcium precipitation method with 2 μg of each lasmid on the HeLa cells. RESULTS: Dexamethasone (DEX) stimulated the transcriptional activity of pTRH(−554/84)-LUC and pTRH(−242/84)-LUC by approximately 3.2 fold at 10(−8) M and 5.4 fold at 10(−6) M. …”
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    Identification of Glucocorticoid Response Element of the Rat TRH gene
  17. 7897
    “…RESULTS: ZALE induced cytotoxicity, nuclear blebbing and DNA fragmentation in HeLA cells suggesting apoptosis induction in human cervical cell line. …”
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    Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC.
  18. 7898
    “…The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions. FINDINGS: HeLa, U2OS, and 1BR-hTERT (normal) cells were pre-treated with 1 μM VE-821 for 1 hour and irradiated with either high LET carbon ions or X-rays. …”
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    VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation
  19. 7899
    “…METHODS: Cervical cancer cell lines HeLa, SiHa and C-33 A were stimulated with PRL (200 ng/mL) for 30 and 60 min and non stimulated cells were used to measure basal protein expression. …”
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    STAT3 activation is required for the antiapoptotic effects of prolactin in cervical cancer cells
  20. 7900
    “…We report that, precisely because they are oxidative, HeLa and SiHa human tumor cells do not activate NF-κB in response to lactate. …”
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    Lactate does not activate NF-κB in oxidative tumor cells
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