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781“…The construct were transfected in HeLa cell line and expression were studied by Western blot as well as Immunefluroscent assay using recombinant sera. …”
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782por Almahdy, Osama, EL-Fakharany, Esmail M., EL-Dabaa, Ehab, Ng, Tzi Bun, Redwan, Elrashdy M.“…However, casein with α-lactalbumin induced a cytotoxic effect in HepG2 and HeLa cell lines but not in human naïve leukocytes. …”
Publicado 2011
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783“…MP significantly inhibited the proliferation of HeLa tumor cell lines. After treatment with MP, characteristic apoptotic features such as DNA fragmentation and chromatin condensation were observed in DAPI-stained HeLa cells. …”
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784por Lee, Gunsup, Yu, Jaelim, Cho, Seungchan, Byun, Sung-June, Kim, Dae Hyun, Lee, Taek-Kyun, Kwon, Myung-Hee, Lee, Sukchan“…Our results demonstrate that the nucleic-acid hydrolyzing activity of 3D8 scFv confers viral resistance to DNA viruses in vitro in HeLa cells and in an in vivo mouse system.…”
Publicado 2014
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785“…Conversely, autophagic HeLa cells after RBAc-PDT exposed and released HSP70, HSP90 but not CRT and ATP. …”
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786por Hu, Xianjing, Zhang, Zhang, Liu, Ting, Song, Liyan, Zhu, Jianhua, Guo, Zhongyi, Cai, Jinghua, Yu, Rongmin“…The results revealed that P2 significantly induced apoptosis of HeLa cells in a concentration- and time-dependent manner. …”
Publicado 2015
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787por Wu, Liang, Zhang, Xiaolong, Zhao, Zhikun, Wang, Ling, Li, Bo, Li, Guibo, Dean, Michael, Yu, Qichao, Wang, Yanhui, Lin, Xinxin, Rao, Weijian, Mei, Zhanlong, Li, Yang, Jiang, Runze, Yang, Huan, Li, Fuqiang, Xie, Guoyun, Xu, Liqin, Wu, Kui, Zhang, Jie, Chen, Jianghao, Wang, Ting, Kristiansen, Karsten, Zhang, Xiuqing, Li, Yingrui, Yang, Huanming, Wang, Jian, Hou, Yong, Xu, Xun“…Recent single-cell RNA-seq studies highlight the tumor heterogeneity present in most cancers, but virally induced tumors have not been studied. HeLa is a well characterized HPV+ cervical cancer cell line. …”
Publicado 2015
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789por Motevaseli, Elahe, Azam, Rosa, Akrami, Seyed Mohammad, Mazlomy, Mohammadali, Saffari, Mojtaba, Modarressi, Mohammad Hossein, Daneshvar, Maryam, Ghafouri-Fard, Soudeh“…RESULTS: The expression of CASP3 and autophagy genes in HeLa cells was de- creased after treatment with lactobacilli culture supernatants. …”
Publicado 2016
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790por Meyer, Arndt, Tetenborg, Stephan, Greb, Helena, Segelken, Jasmin, Dorgau, Birthe, Weiler, Reto, Hormuzdi, Sheriar G., Janssen-Bienhold, Ulrike, Dedek, Karin“…Using newly generated anti-connexin30.2 antibodies, we show in HeLa cells that both connexins are indeed able to interact and may form heteromeric channels: both connexins were co-immunoprecipitated from transiently transfected HeLa cells and connexin30.2 gap junction plaques became significantly larger when co-expressed with connexin36. …”
Publicado 2016
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791por Rank, Lisa, Veith, Sebastian, Gwosch, Eva C., Demgenski, Janine, Ganz, Magdalena, Jongmans, Marjolijn C., Vogel, Christopher, Fischbach, Arthur, Buerger, Stefanie, Fischer, Jan M.F., Zubel, Tabea, Stier, Anna, Renner, Christina, Schmalz, Michael, Beneke, Sascha, Groettrup, Marcus, Kuiper, Roland P., Bürkle, Alexander, Ferrando-May, Elisa, Mangerich, Aswin“…We genetically deleted PARP1 in one of the most widely used human cell systems, i.e. HeLa cells, via TALEN-mediated gene targeting. After comprehensive characterization of these cells during genotoxic stress, we analyzed structure–function relationships of PARP1 by reconstituting PARP1 KO cells with a series of PARP1 variants. …”
Publicado 2016
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792por Zhang, Pengyu, Zhao, Xuan, Zhang, Wenjuan, He, Aili, Lei, Bo, Zhang, Wanggang, Chen, Yinxia“…We generated a HeLa cell line stably expressing MLAA-34 and found that MLAA-34 overexpression had no effect on the growth, apoptosis and cell cycle of HeLa cells. …”
Publicado 2017
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793por Sesso, Antonio, Yamashiro-Kanashiro, Edite Hatsumi, Arruda, Liã Bárbara, Kawakami, Joyce, Higuchi, Maria de Lourdes, Orii, Noemia Mie, Taniwaki, Noemi Nosomi, Carvalho, Flávia Mendes da Cunha, Brito, Mariane Pereira, Gottardi, Maiara, Carneiro, Sylvia Mendes, Taga, Rumio“…A study with transmission electron microscopy of mycoplasma-contaminated HeLa cells using five cell donors referred to as donors A, B, C, D and E, observations are herein presented. …”
Publicado 2017
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794“…Pulse field gel electrophoresis using a contour‐clamped homogeneous electric field was applied for the analysis of DNA‐fragmenting activity of antitumor agents towards human uterine cervix carcinoma HeLa S(3) cells. Duocarmycins (DUMs), novel antitumor antibiotics with ultrapotent cell growth‐inhibitory activities, caused DNA fragmentation at 10 times their IC(50) values at 2 h exposure. …”
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795por Akaboshi, Mitsuhiko, Kawai, Kenichi, Kinashi, Yuko, Masunaga, Shinichiro, Ono, Koji“…The effect of hyperthermia on the cell‐killing efficiency of Pt atoms binding to DNA, RNA and protein molecules was examined. HeLa S‐3 cells were treated with (195m)Pt‐radiolabeled trans‐diaminedichloro‐platinum(II) (TDDP) for 60 min at various temperatures, and the relationship between the lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. …”
Publicado 1997
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796“…However, the mechanism of action of propofol in HeLa human cervical cancer cells has not been elucidated. …”
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797por Koyuncu, Ismail, Gonel, Ataman, Kocyigit, Abdurrahim, Temiz, Ebru, Durgun, Mustafa, Supuran, Claudiu T.“…One compound showed remarkably high toxicity towards CA IX-positive HeLa cells. The mechanisms of apoptosis induction were determined with Annexin-V and AO/EB staining, cleaved caspases (caspase-3, caspase-8, caspase-9) and cleaved PARP activation, reactive oxygen species production (ROS), mitochondrial membrane potential (MMP), intracellular pH (pHi), extracellular pH (pHe), lactate level and cell cycle analysis. …”
Publicado 2018
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798por Aco-Tlachi, Miguel, Carreño-López, Ricardo, Martínez-Morales, Patricia L., Maycotte, Paola, Aguilar-Lemarroy, Adriana, Jave-Suárez, Luis Felipe, Santos-López, Gerardo, Reyes-Leyva, Julio, Vallejo-Ruiz, Verónica“…RESULTS: The microarray analysis showed 9 glycogenes that were upregulated and 7 glycogenes that were downregulated in HeLa shE6/E7 cells. Some of these genes participate in glycosylation related to Notch proteins and O-glycans antigens. …”
Publicado 2018
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799por Ni, Guoying, Chen, Shu, Chen, Mo, Wu, Jialing, Yang, Binbin, Yuan, Jianwei, Walton, Shelley F., Li, Hejie, Wei, Ming Q., Wang, Yuejian, Chen, Guoqiang, Liu, Xiaosong, Wang, Tianfang“…However, the mechanism underlying their anti-proliferative activities against HPV18+ cervical cancer HeLa cells remains unknown. This study comparatively investigated the anti-proliferation on HeLa cells by caerin 1.1, 1.9, and their mixture, followed by confocal microscopy examination to assess the cellular intake of the peptides. …”
Publicado 2020
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800“…This research addresses the growth inhibitory efficacy of rutin against E6 and E7 oncoproteins in HeLa cells, which is known to inactivate several tumor suppressor proteins such as p53 and pRB. …”
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