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8061“…Results demonstrate that p105 levels are elevated several-fold in O. tsutsugamushi infected HeLa and RF/6A cells with only a nominal increase in p50. …”
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8062“…A xenograft assay showed that PRDM4 overexpression in the cervical cancer cell lines SiHa and HeLa dramatically inhibited cell proliferation and tumorigenic potential in vivo. …”
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8063por van der Welle, Reini E N, Jobling, Rebekah, Burns, Christian, Sanza, Paolo, van der Beek, Jan A, Fasano, Alfonso, Chen, Lan, Zwartkruis, Fried J, Zwakenberg, Susan, Griffin, Edward F, ten Brink, Corlinda, Veenendaal, Tineke, Liv, Nalan, van Ravenswaaij‐Arts, Conny M A, Lemmink, Henny H, Pfundt, Rolph, Blaser, Susan, Sepulveda, Carolina, Lozano, Andres M, Yoon, Grace, Santiago‐Sim, Teresa, Asensio, Cedric S, Caldwell, Guy A, Caldwell, Kim A, Chitayat, David, Klumperman, Judith“…Cellular consequences were investigated in patient fibroblasts and VPS41‐depleted HeLa cells. All mutants prevented formation of a functional HOPS complex, causing delayed lysosomal delivery of endocytic and autophagic cargo. …”
Publicado 2021
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8064por IJff, Marloes, van Bochove, Gregor G. W., Whitton, Denise, Winiarczyk, Roy, Honhoff, Celina, Rodermond, Hans, Crezee, Johannes, Stalpers, Lukas J. A., Franken, Nicolaas A. P., Oei, Arlene L.“…This was studied in cervical cancer cell lines (SiHa, HeLa, C33A and CaSki) treated with hyperthermia (42 °C) ± ionizing radiation (2–6 Gy) ± cisplatin (0.3–0.5 µM) ± PARP1-inhibitor (olaparib, 4.0–5.0 µM). …”
Publicado 2021
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8065por Chiu, Hock Ing, Che Mood, Che Nurul Azieyan, Mohamad Zain, Nur Nadhirah, Ramachandran, Muggundha Raoov, Yahaya, Noorfatimah, Nik Mohamed Kamal, Nik Nur Syazni, Tung, Wai Hau, Yong, Yoke Keong, Lee, Chee Keong, Lim, Vuanghao“…The AgNPs were also proven to possess cytotoxic effects on the breast (MCF-7), cervical (HeLa), and colon (HT-29) cancer cells in a dose-dependent manner. …”
Publicado 2021
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8066por Gobinath, Perumal, Packialakshmi, Ponnusamy, Vijayakumar, Kaliappillai, Abdellattif, Magda H., Shahbaaz, Mohd, Idhayadhulla, Akbar, Surendrakumar, Radhakrishnan“…The result of cytotoxicity indole compound 1c (HepG2, LC(50)−0.9 μm, MCF−7, LC(50)−0.55 μm, HeLa, LC(50)−0.50 μm) was found to have high activity compared with other compounds used for the same purpose. …”
Publicado 2021
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8067por Kishita, Yoshihito, Ishikawa, Kaori, Nakada, Kazuto, Hayashi, Jun-Ichi, Fushimi, Takuya, Shimura, Masaru, Kohda, Masakazu, Ohtake, Akira, Murayama, Kei, Okazaki, Yasushi“…We performed functional assays using cybrid cell models generated by fusing mtDNA-less rho0 HeLa cells with enucleated cells from patient fibroblasts carrying the m.14597A>G variant. …”
Publicado 2021
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8068por Daks, Alexandra, Petukhov, Alexey, Fedorova, Olga, Shuvalov, Oleg, Kizenko, Alena, Tananykina, Elizaveta, Vasileva, Elena, Semenov, Oleg, Bottrill, Andrew, Barlev, Nickolai“…Importantly, the Pirh2-mediated degradation of HuR occurred in response to heat shock, thereby affecting the survival rate of HeLa cells under elevated temperature. Functionally, Pirh2-mediated degradation of HuR augmented the level of c-Myc expression, whose RNA level is otherwise attenuated by HuR. …”
Publicado 2021
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8069por Tavakkoli Yaraki, Mohammad, Wu, Min, Middha, Eshu, Wu, Wenbo, Daqiqeh Rezaei, Soroosh, Liu, Bin, Tan, Yen Nee“…The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. …”
Publicado 2021
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8070“…Also has anticancer activity against HeLa cancer cell line. While the acetone fraction has potent antioxidant activity with IC(50) 5 µg/mL. …”
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8071por Afonin, Sergii, Koniev, Serhii, Préau, Laetitia, Takamiya, Masanari, Strizhak, Alexander V., Babii, Oleg, Hrebonkin, Andrii, Pivovarenko, Vasyl G., Dathe, Margitta, le Noble, Ferdinand, Rastegar, Sepand, Strähle, Uwe, Ulrich, Anne S., Komarov, Igor V.“…This feature allowed us to get insights into conformational equilibria of the labeled peptides, localize the cWFW analogues in human cells (HeLa and HEK293) and zebrafish embryos, and assess the polarity of the local environment around the label by confocal fluorescence microscopy. …”
Publicado 2021
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8072por Higgins, Nicole R., Greenslade, Jessie E., Wu, Josephine J., Miranda, Elena, Galliciotti, Giovanna, Monteiro, Mervyn J.“…A similar phenomenon of serpin protein aggregation was found in HeLa and NSC34 motor neuron cells with inactivated UBQLN2 expression. …”
Publicado 2021
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8073“…AIM: To demonstrate the existence and infectivity of human coronavirus RNA in surgical smoke using a model experiment and to evaluate the possibility of lowering transmission risk by filtration through a surgical mask. METHODS: Pelleted HeLa-ACE2-TMPRSS2 cells infected with human coronavirus were incised by electric scalpel and ultrasonic scalpel, separately. …”
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8074por Pons, Benoît J., Pettes-Duler, Aurélie, Naylies, Claire, Taieb, Frédéric, Bouchenot, Catherine, Hashim, Saleha, Rouimi, Patrick, Deslande, Maxime, Lippi, Yannick, Mirey, Gladys, Vignard, Julien“…Here, we show that chronic exposure to CDT in HeLa cells or mouse embryonic fibroblasts promotes a strong type I interferon (IFN) response that depends on the cytoplasmic DNA sensor cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) through the recognition of micronuclei. …”
Publicado 2021
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8075por Farràs, Adrià, Mitjans, Montserrat, Maggi, Filippo, Caprioli, Giovanni, Vinardell, María Pilar, López, Víctor“…Specifically, we have characterized the methanolic extract of P. vulgare fronds (PVM) by HPLC-DAD and investigated its potential cytotoxicity, phototoxicity, ROS production and protective effects against oxidative stress by using in vitro methods. The 3T3, HaCaT, HeLa, HepG2, MCF-7 and A549 were the cell lines used to evaluate the possible cytotoxic behaviour of the PVM. …”
Publicado 2021
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8076por Rácz, Gergely Attila, Nagy, Nikolett, Tóvári, József, Apáti, Ágota, Vértessy, Beáta G.“…For this purpose, we investigated the expression of 12 candidate reference genes in 13 widely used human cancer cell lines (HeLa, MCF-7, A-549, K-562, HL-60(TB), HT-29, MDA-MB-231, HCT 116, U-937, SH-SY5Y, U-251MG, MOLT-4 and RPMI-8226) and, in addition, 7 normal cell lines (HEK293, MRC-5, HUVEC/TERT2, HMEC, HFF-1, HUES 9, XCL-1). …”
Publicado 2021
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8077“…The cytotoxicity of various WU extracts was evaluated with HeLa (cervical cancer), HepG2 (liver cancer), HT-29 (colorectal cancer), and A549 (non-small cell lung cancer) cells by means of Sulforhodamine B (SRB) assay. …”
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8078por Aoki, Yoshitsugu, Rocha, Cristina S. J., Lehto, Taavi, Miyatake, Shouta, Johansson, Henrik, Hashimoto, Yasumasa, Nordin, Joel Z., Mager, Imre, Aoki, Misako, Graham, McClorey, Sathyaprakash, Chaitra, Roberts, Thomas C., Wood, Matthew J. A., Behlke, Mark A., Andaloussi, Samir El“…Ablation of one of them, Ncl by small-interfering RNA (siRNA) enhanced 2OMePS uptake in C2C12 myoblasts and upregulated luciferase RNA splicing in the HeLa Luc/705 reporter cell line. Overall, we demonstrate that PS inclusion increases nuclear delivery and splice switching in muscle, neuronal, liver, and bone cell lineages and that the modulation of 2OMePS-binding partners may improve SSO delivery.…”
Publicado 2021
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8079por Chen, Jie, Liu, Nan, Huang, Yinpin, Wang, Yuanxun, Sun, Yuxing, Wu, Qingcui, Li, Dianrong, Gao, Shuanhu, Wang, Hong-Wei, Huang, Niu, Qi, Xiangbing, Wang, Xiaodong“…In this work, we report the high-resolution cryo-electron microscopy structure of PDE3A-SLFN12 complexes isolated from cultured HeLa cells pre-treated with either anagrelide, or nauclefine, or DNMDP. …”
Publicado 2021
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8080por Oleksa, Viktoriia, Macková, Hana, Engstová, Hana, Patsula, Vitalii, Shapoval, Oleksandr, Velychkivska, Nadiia, Ježek, Petr, Horák, Daniel“…UCNP with various charges were then studied as labels of carcinoma cells, including human hepatocellular carcinoma HepG2, human cervical cancer HeLa, and rat insulinoma INS-1E cells. All the particles proved to be biocompatible (nontoxic); depending on their ξ-potential, the ability to penetrate the cells differed. …”
Publicado 2021
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