“…IP-MS identified 100 potential Kpnβ1 binding partners in non-cancer hTERT-RPE1, 179 in HeLa cervical cancer, 147 in WHCO5 oesophageal cancer and 176 in KYSE30 oesophageal cancer cells, including expected and novel interaction partners. 38 binding proteins were identified in all cell lines, with the majority involved in RNA metabolism. 18 binding proteins were unique to the cancer cells, with many involved in protein translation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PF-00835231 can inhibit not only cell infection (such as Vero E6, 293T, Huh-7.5, HeLa(+angiotensin-converting enzyme 2 (ACE2)), A549(+ACE2), and MRC-5) but also the human respiratory epithelial organ model and animal model infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…They were more efficient against Aspergillus ochraceus (MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, only SS-AgNPs reveal an inhibitory action against the HeLa cell line, where the IC(50) is found to be 26.8 μg mL(−1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In vitro, after REBACIN(®) treatment, the growth of both Ca Ski and HeLa cervical cancer cells containing the E6/E7 oncogenes was prevented. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Taking advantage of CuAAC, we compared the metabolic incorporation of ManNAl, ManNAz, SiaNAl, SiaNAz and Ac(4)ManNAz in the human colon cell lines CCD841CoN, HT29 and HCT116, and in the two gold standard cell lines, HEK293 and HeLa. Using complementary approaches, we showed marked differences in the efficiency of labeling of sialoglycoproteins between the different chemical reporters in a given cell line, and that switching the azide and alkyne bioorthogonal tags on the analogs highly impacted their metabolic incorporation in the human colon cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The ability to visualize cell components of the studied dyes has been evaluated using different human cell lines (MCF-7, A2780, HeLa, and Hs27). We have shown that all dyes are cell-permeant staining nucleus components, probably RNA-rich nucleoli with background fluorescence in the cytoplasm, except for the dye T-5. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On the other hand, all the Citrus oils exhibit potent antiproliferative activities against the HeLa cervical cancer cell line, with IC(50) values of 11.66 μg/mL (C. limon), 20.41 μg/mL (C. microcarpa), 25.91 μg/mL (C. hystrix), and 87.17 μg/mL (C. pyriformis).…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The objective of the present study was (i) to characterize the chemical composition of flower heads of A. montana plants cultivated under nitrogen fertilization, (ii) to identify the impact of the nitrogen fertilization and extraction method (water, ethanol) on the antioxidant activity of extracts, and (iii) to determine the role of different nitrogen doses applied during plant cultivation and different extraction methods in the anticancer activity of the extracts through analysis of apoptosis and autophagy induction in HT29, HeLa, and SW620 cell lines. The present study shows that nitrogen is a crucial determinant of the chemical composition of arnica flower heads and the antioxidant and anticancer activity of the analyzed extracts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The potential of the investigated complex to be an anticancer drug has been examined by employing the MTT assay technique, which is carried out on HeLa cancer cell lines and HEK-293 normal cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, all isolated compounds except for 5 significantly induced the death of Adriamycin (ADR)-treated HeLa cells. Interestingly, 1–4, 6, and 7 didn’t show anti-proliferative and cell death-inducing activity without ADR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, it displayed notable cytotoxic effects against MCF-7 (breast carcinoma, IC(50) = 22.4 µg mL(−1)), HeLa (cervical carcinoma, IC(50) = 28.9 µg mL(−1)) and HepG-2 (liver carcinoma, IC(50) = 28.9 µg mL(−1)). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using the nHi-C experiment, we identify 264 high-confidence nucleolus-associated domains (hNADs) that form strong heterochromatin interactions associated with the nucleolus and consist of 24% of the whole genome in HeLa cells. Based on the global hNAD inter-chromosomal interactions, we find five nucleolar organizer region (NOR)-bearing chromosomes formed into two clusters that show different interaction patterns, which is concordant with their epigenetic states and gene expression levels. hNADs can be divided into three groups that display distinct cis/trans interaction signals, interaction frequencies associated with nucleoli, distance from the centromeres, and overlap percentage with lamina-associated domains (LADs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Enhanced calcium signaling and cell migration are also observed in NCI-H23 and HeLa cells, which coexpress CXCR4 and HRH1. Taken together, our findings demonstrate an interplay between CXCR4 and HRH1, and suggest the possibility of the CXCR4-HRH1 heteromer as a potential therapeutic target for anticancer therapy.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Compared with cisplatin, P-CyPt greatly improves antitumor efficacy while mitigates off-target toxicity in mice with subcutaneous HeLa tumors and orthotopic HepG2 liver tumors after systemic administration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In cytotoxic study, we performed in vitro hemolysis assay on domestic sheep peripheral blood and MTT [3–(4,5–dimethylthiazol–2–yl)–2,5–diphenyltetrazolium bromide] assay on human cervical HeLa, ovarian SKOV-3, and breast MCF-7 cancer cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We had previously reported that CVB3 infections rely on the activation of transient receptor vanilloid potential 1 (TRPV1) and found that inhibiting TRPV1 activity with SB-366791 significantly limited CVB3 infection of HeLa cervical cancer cells. Similarly in this study, we observed that treating iBECs with SB-366791 significantly reduced CVB3 infection, which suggests that not only can this drug potentially limit viral entry into the brain, but also demonstrates that this infection model could be a valuable platform for testing antiviral treatments of neurotropic viruses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An exhaustive in vitro MTT assay by CMT-AgNPs and CMT against A549, HT29, HeLa and L929 cell lines revealed the capability of CMT-AgNPs as a potential anticancer agent.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We obtained the HSPA5-bound RNA profile in HeLa cells and peak calling analysis revealed that HSPA5 binds to coding genes and lncRNAs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Lymphocyte antigen 6 complex locus K expression level is elevated in higher grade cervical cancer patients correlating with poor overall survival, progression‐free survival, and disease‐free survival. LY6K‐depletion in HeLa and SiHa cancer cells suppressed EGF‐induced proliferation and TGF‐β‐enhanced migration and invasion. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso