“…Combining spatial and abundance information yielded an unprecedented quantitative view of HeLa cell anatomy and organellar composition, at the protein level. …”
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“…The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake. Using confocal microscopy, live‐cell imaging, targeted RNAi screening and perturbants of endosome maturation, we analyzed the properties and maturation pathway of the macropinocytic vacuoles containing VACV MVs in HeLa cells. …”
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“…To prove this hypothesis, internalization and localization studies in HeLa cancer cells were performed using flow cytometry and confocal microscopy. …”
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“…Interestingly, a number of ProTides showed low micromolar activity against CEM and HeLa cells compared to the inactive parent BVdU. …”
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“…NHERF1 overexpression inhibited proliferation and enhanced apoptosis in cisplatin-resistant HeLa cells, whereas NHERF1 knockdown had inverse effects. …”
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“…In contrast to H(2)O(2), PTEN oxidation by t-BHP was irreversible in HeLa cells. However, oxidized PTEN was reduced by exogenous Trx system. …”
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“…The absorbance and photokilling effect on HeLa cells upon visible light of different regions were also studied and compared with non-doped TiO(2)-Pc and Pc. …”
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“…In anticipation of the proliferation of time series data sets in the near future, we use the Hopfield model, a recurrent neural network based on spin glasses, to model the dynamics of cell cycle in HeLa (human cervical cancer) and S. cerevisiae cells. …”
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“…As the UPR is essential for successful ER homeostatic readjustment in the HeLa-µ(s) model, it provides an ideal system for dissecting the intricacies of how the UPR evaluates and alleviates ER stress.…”
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“…We investigated the inhibitory effects of aurochloric acid (AuCl(4)H) on reverse transcriptase (RT) derived from avian myeloblastosis virus and DNA polymerase a (pol. a) purified from HeLa S3 cells. The activities of RT, pol. a and E. coli DNA polymerase I (pol. …”
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“…Suspension‐cultured HeLa cells possess a cytosolic‐nuclear tumor promoter‐specific binding protein (CN‐TPBP) which lacks protein kinase C activity. …”
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“…Under red light irradiation (λ = 660 nm, 1.5 J/cm(2)), both photosensitizers show high and comparable cytotoxicity towards HepG2 human hepatocarcinoma and HeLa human cervical carcinoma cells with IC(50) values of 0.42–0.49 μM. …”
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“…[Image: see text] We tested the targeting efficiency of magnetoliposomes (MLPs) labeled with tripeptide arginine-glycine-aspartic acid (RGD) on two types of cells: HeLa cells expressing RGD receptors and 3T3 cells lacking RGD receptors. …”
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“…In the present study, we evaluated the radiosensitizing effects of the water-soluble sinomenine, sinomenine hydrochloride (SH) in human cervical cancer cell line (HeLa). SH sensitized HeLa cells to ionizing radiation (IR) by promoting accumulation of IR-induced DNA double-strand breaks (DSBs) and also by interfering with DNA damage checkpoint activation. …”
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“…These liposomes elicited a significant effect on cell viability and triggered apoptosis in HeLa cells.…”
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“…Herein, we chose LPS as an inducer to establish an inflammatory model of HeLa cells, and explored the effects of LPS on energy metabolism. …”
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“…We examined the cytotoxic and apoptotic activities of psoralidin in combination with TRAIL on HeLa cancer cells. The cytotoxicity was measured by MTT and LDH assays. …”
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“…All prodrug compounds demonstrated much greater in vitro antitumor activities against HeLa cells and SGC-7901 cells than irinotecan. The most active compounds, 5h, 7c, 7d, and 7f, exhibited IC(50) values that were 1000 times lower against HeLa cells and 30 times lower against SGC-7901 cells than those of irinotecan, and the inhibitory activities of these prodrugs against acetylcholinesterase (AchE) were significantly reduced, with IC(50) values more than 6.8 times greater than that of irinotecan. …”
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“…The cytotoxic activities of the compounds were evaluated against HeLa, MCF-7, KMST-6 and HT-29 cells using the WST-1 assay. …”
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“…The biological activity test results indicated that the 90% acetone extract showed cytotoxicity against the human lung adenocarcinoma (A549) cell line (IC(50) = 0.98 ± 0.1 μg/mL), compound 6 showed cytotoxicities against human cervical carcinoma (HeLa) (IC(50) = 0.4 ± 0.1 μM ) and human gastric carcinoma (BGC-823) (IC(50) = 0.9 ± 0.2 μM) cancer cell lines, and compound 19 showed cytotoxicities against HeLa (IC(50) = 1.5 ± 0.4 μM), BGC-823 (IC(50) = 7.0 ± 0.8 μM ), and A549 (IC(50) = 10.6 ± 1.5 μM ) cancer cell lines.…”
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