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9601por Yamamoto, Shumpei, Onishi, Hideki, Oyama, Atsushi, Takaki, Akinobu, Okada, Hiroyuki“…A 78-year-old man with chronic hepatitis C underwent hepatectomy for hepatocellular carcinoma (HCC) 11 years prior to presentation. …”
Publicado 2019
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9602por Roehlen, Natascha, Roca Suarez, Armando Andres, El Saghire, Houssein, Saviano, Antonio, Schuster, Catherine, Lupberger, Joachim, Baumert, Thomas F.“…Moreover, TJ proteins are hepatocyte entry factors for the hepatitis C virus (HCV)—a major cause of liver disease and cancer worldwide. …”
Publicado 2020
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9603por Huang, Diana D.“…Therapeutic strategies using RNAi against viruses that cause chronic infections, such as HIV, hepatitis B virus, or hepatitis C virus, are more difficult to design, but studies have begun to address identifiable problems. …”
Publicado 2008
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9604“…Type III IFNs also target the human liver, with dual effects: they induce an antiviral state in hepatocytes, but specific IFN-λ4 action impairs the clearance of hepatitis C virus and could influence inflammatory responses. …”
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9605“…Thus, these viral proteins, which include influenza A virus matrix protein 2 (M2), HIV-1 viral protein U (Vpu) and hepatitis C virus p7, represent ideal targets for therapeutic intervention, and several compounds that block their pore-forming activity have been identified. …”
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9606“…To evaluate the usefulness of a standardized commercial amplification assay for detection of hepatitis C virus (HCV) RNA, Amplicor® HCV Test (Roche), a total of 1,204 serum samples from 888 patients was examined. …”
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9607“…In our department 28% of cirrhotic liver transplant recipients are transplanted for hepatitis C virus (HCV)-related liver disease and 26% undergo OLT for alcohol-related liver disease. …”
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9608“…Infection with hepatitis viruses may be more severe in older adults with more fulminate disease as observed with acute hepatitis A and a more rapid progression to cirrhosis with hepatitis C. Outbreaks of viral gastroenteritis are common in long-term care facilities, and infection may lead to death due to dehydration and oliguria. …”
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9609“…Transplantation of hepatitis C virus (HCV)-positive organs has undergone a paradigm shift because of the advent of direct-acting antivirals. …”
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9610“…We report a man with decompensated hepatitis C cirrhosis who developed hemocholecyst complicated by perforation with hemoperitoneum soon after endoscopic variceal ligation of the esophageal varices in the setting of retrospectively discovered gallbladder varices.…”
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9611por Cosset, François-Loïc, Mialon, Chloé, Boson, Bertrand, Granier, Christelle, Denolly, Solène“…Hepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. …”
Publicado 2020
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9612“…The accurate genotyping of hepatitis C virus (HCV) is crucial to achieving this goal because it is vital for the selection of anti-HCV therapy required for complete cure of HCV infection. …”
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9613por Hindilerden, Fehmi, Yonal-Hindilerden, Ipek, Sevtap, Senoglu, Kart-Yasar, Kadriye“…Many viruses have been identified as triggers of the autoimmune process, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus, rubella, and measles. …”
Publicado 2020
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9614por Ahmad, Mohammed, Dwivedy, Abhisek, Mariadasse, Richard, Tiwari, Satish, Kar, Deepsikha, Jeyakanthan, Jeyaraman, Biswal, Bichitra K.“…This site was computationally targeted using a number of small molecule inhibitors of the hepatitis C RNA polymerase reported previously. Further optimizations suggested a lead molecule that may prove fruitful in the development of potent inhibitors against the RdRp of SARS-CoV2.…”
Publicado 2020
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9615“…It has been associated with a multitude of severe infectious complications, such as hepatitis B, hepatitis C, human immunodeficiency virus, and endocarditis, though others such as skin and soft tissue infections are also extremely common. …”
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9616por Litwin, Alain H, Shafner, Laura, Norton, Brianna, Akiyama, Matthew J, Agyemang, Linda, Guzman, Mercedes, Vera, Tatiana, Heo, Moonseong“…This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. …”
Publicado 2020
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9617por Subramanian, Sruthi Kapliyil, Patel, Jigar M., Younes, Mamoun, Nevah Rubin, Moises I.“…Several studies have documented the involvement of genetic factors and triggering agents such as toxic injury, treatment with immune-modifying drugs, or previous viral infections with perhaps strongest evidence for the hepatitis C virus. Rarely, AIH has been reported to develop after hepatitis A virus infection. …”
Publicado 2020
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9618por Svegliati-Baroni, Gianluca, Patrício, Bárbara, Lioci, Gessica, Macedo, Maria Paula, Gastaldelli, Amalia“…Due to its association with obesity and diabetes and the fall in hepatitis C virus morbidity, cirrhosis in NAFLD is becoming the most frequent indication to liver transplantation, but the pathogenetic mechanisms are still not completely understood. …”
Publicado 2020
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9619por Lundstrom, Kenneth“…Viral gene silencing by targeting the RNAi pathway showed efficient suppression of hepatitis B virus replication by adeno-associated virus (AAV)-based delivery of RNAi hepatitis B virus (HBV) cassettes. Hepatitis C virus replication has been targeted by short hairpin RNA molecules expressed from lentivirus vectors. …”
Publicado 2020
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9620Synthesis and Antiviral Activity of a Series of 2′-C-Methyl-4′-thionucleoside Monophosphate Prodrugs“…The NS5B RNA-dependent RNA polymerase of the hepatitis C virus (HCV) is a validated target for nucleoside antiviral drug therapy. …”
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