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10621“…The experiments were based on a model innate immune activating RNA molecule, the polyU/UC RNA domain of hepatitis C virus, which was transcribed in vitro with canonical nucleotides or with one of eight modified nucleotides. …”
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10622por Marascio, Nadia, Pavia, Grazia, Strazzulla, Alessio, Dierckx, Tim, Cuypers, Lize, Vrancken, Bram, Barreca, Giorgio Settimo, Mirante, Teresa, Malanga, Donatella, Oliveira, Duarte Mendes, Vandamme, Anne-Mieke, Torti, Carlo, Liberto, Maria Carla, Focà, Alfredo“…Naturally occurring resistance-associated substitutions (RASs) can negatively impact the response to direct-acting antivirals (DAAs) agents-based therapies for hepatitis C virus (HCV) infection. Herein, we set out to characterize the RASs in the HCV1b genome from serum samples of DAA-naïve patients in the context of the SINERGIE (South Italian Network for Rational Guidelines and International Epidemiology, 2014) project. …”
Publicado 2016
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10623“…The first was to examine distributions of Hepatitis C Virus (HCV) genotypes in Sindh, Pakistan, where HCV is prevalent. …”
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10624por Li, Yujia, Li, Shilin, Duan, Xiaoqiong, Chen, Yanzhao, Jiao, Baihai, Ye, Haiyan, Yao, Min, Chen, Limin“…Activation of type I IFN signaling pathway leads to expressions of IFN-stimulated genes (ISGs) which play important roles in antiviral and immunomodulatory responses to HBV or hepatitis C virus (HCV) infection. Our previous studies indicated that ISG15 and its conjugation (ISGylation) were exploited by HCV to benefit its replication and persistent infection. …”
Publicado 2016
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10625por Siddharta, Anindya, Pfaender, Stephanie, Malassa, Angelina, Doerrbecker, Juliane, Anggakusuma, Engelmann, Michael, Nugraha, Boya, Steinmann, Joerg, Todt, Daniel, Vondran, Florian W. R., Mateu-Gelabert, Pedro, Goffinet, Christine, Steinmann, Eike“…Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. …”
Publicado 2016
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10626por Akce, Mehmet, Chang, Elaine, Haeri, Mohammad, Perez, Mike, Finch, Christie J., Udden, Mark M., Mims, Martha P.“…We present a case of a 53-year-old HIV-negative man with untreated hepatitis C viral infection who presented with abdominal pain and lymphadenopathy. …”
Publicado 2016
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10627“…Serological tests demonstrated the presence of hepatitis B infection in 18 (10.6%) patients and hepatitis C infection in 39 (23%) patients, serological markers for autoimmune hepatitis were positive in two female patients, one diagnosed chronic intrahepatic cholestasis. …”
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10628“…CASE PRESENTATION: We report the case of an 80-year-old Moroccan man, who was positive for hepatitis c virus, presenting an intermediate stage hepatocellular carcinoma (three lesions between 20 and 60 mm). …”
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10629“…Hepatitis C virus (HCV) infection induces intracellular membrane rearrangements, thus forming a membranous web (MW) in which HCV replication and assembly occur. …”
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10630“…They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recent literatures on one member of the SF2 superfamily, the DEAD-box protein DDX41. …”
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10631por Ukawa, Shigekazu, Okada, Emiko, Nakamura, Koshi, Hirata, Makoto, Nagai, Akiko, Matsuda, Koichi, Yamagata, Zentaro, Kamatani, Yoichiro, Ninomiya, Toshiharu, Kiyohara, Yutaka, Muto, Kaori, Kubo, Michiaki, Nakamura, Yusuke, Tamakoshi, Akiko“…Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. …”
Publicado 2017
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10632“…With the prevalence of hepatitis C virus expected to decline, the proportion of hepatocellular carcinoma (HCC) related to non-alcoholic steatohepatitis (NASH) is anticipated to increase exponentially due to the growing epidemic of obesity and diabetes. …”
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10633Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cellspor Kozak, Robert A., Hattin, Larissa, Biondi, Mia J., Corredor, Juan C., Walsh, Scott, Xue-Zhong, Max, Manuel, Justin, McGilvray, Ian D., Morgenstern, Jason, Lusty, Evan, Cherepanov, Vera, McBey, Betty-Anne, Leishman, David, Feld, Jordan J., Bridle, Byram, Nagy, Éva“…It was determined that one mechanism of cell death was through syncytia formation, resulting in apoptosis and induction of interferon stimulated genes (ISGs). As hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma worldwide, we investigated the effect of ARV-PB1 against cells already infected with this virus. …”
Publicado 2017
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10634por Bracho, Maria Alma, García-Robles, Inmaculada, Jiménez, Nuria, Torres-Puente, Manuela, Moya, Andrés, González-Candelas, Fernando“…RESULTS: To investigate the role of oligonucleotide design in estimating viral variability within hosts, genetic diversity in hepatitis C virus (HCV) populations from eight infected patients was characterised by two parallel PCR amplifications performed with two slightly different sets of primers, followed by cloning and sequencing (mean = 89 cloned sequences per patient). …”
Publicado 2004
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10635por Read, Scott A., O'Connor, Kate S., Suppiah, Vijay, Ahlenstiel, Chantelle L. E., Obeid, Stephanie, Cook, Kristina M., Cunningham, Anthony, Douglas, Mark W., Hogg, Philip J., Booth, David, George, Jacob, Ahlenstiel, Golo“…Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease. …”
Publicado 2017
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10636por Foley, Kendra C., Spear, Timothy T., Murray, David C., Nagato, Kaoru, Garrett-Mayer, Elizabeth, Nishimura, Michael I.“…We have introduced these modifications into our hepatitis C virus (HCV) reactive TCR and utilize a marker gene, CD34t, which allows us to directly compare transduction efficiency with TCR expression and T cell function. …”
Publicado 2017
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10637“…However, this CTL response is frequently weak or undetectable in patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are receptors in the CD28 family of costimulatory molecules, providing inhibitory signals to T cells. …”
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10638“…Viral hepatitis B in children was 3.5% in 2006 and dropped in 2011; and in adults, it ranged from 4.5 to 10.8%. Viral hepatitis C was between 0.87 and 14.7%. No data are available for hepatitis D in the country. …”
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10639por Theotokis, Pantazis I., Usher, Louise, Kortschak, Christopher K., Schwalbe, Ed, Moschos, Sterghios A.“…However, the inherent genomic instability of RNA viruses such as hepatitis C virus (HCV) gives rise to quasi-species mutants within discrete clones: this facilitates mismatch tolerance studies from a target perspective. …”
Publicado 2017
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10640por Megger, Dominik A., Philipp, Jos, Le-Trilling, Vu Thuy Khanh, Sitek, Barbara, Trilling, Mirko“…Interestingly, the new class of IFN-repressed genes comprises known host factors for highly relevant pathogens such as HIV, dengue virus, and hepatitis C virus.…”
Publicado 2017
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