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14501por Vijgen, Leen, Thys, Kim, Vandebosch, An, Van Remoortere, Pieter, Verloes, René, De Meyer, Sandra“…BACKGROUND: In study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir (SMV), non-nucleoside NS5B inhibitor TMC647055/ritonavir (RTV) and NS5A inhibitor JNJ-56914845 resulted in high sustained virologic response 12 weeks after actual end of treatment (SVR12) in chronic hepatitis C virus (HCV) genotype 1-infected patients. …”
Publicado 2017
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14502por Jang, Tyng-Yuan, Lin, Pei-Chin, Huang, Ching-I, Liao, Yu-Mei, Yeh, Ming-Lun, Zeng, Yu-Sheng, Liang, Po-Cheng, Hsu, Wan-Yi, Tsai, Shih-Pien, Lin, Zu-Yau, Chen, Shinn-Cherng, Huang, Jee-Fu, Dai, Chia-Yen, Huang, Chung-Feng, Chiou, Shyh-Shin, Chuang, Wan-Long, Yu, Ming-Lung“…We aimed to evaluate the prevalence and factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection among transfusion-dependent patients in Taiwan. …”
Publicado 2017
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14503por Williams, Chad M., Schonnesen, Alexandra A., Zhang, Shu-Qi, Ma, Ke-Yue, He, Chenfeng, Yamamoto, Tori, Eckhardt, S. Gail, Klebanoff, Christopher A., Jiang, Ning“…CD8 contribution in a native human antigen-specific T cell response remains elusive. Here, using Hepatitis C Virus-specific precursor CTLs spanning a large range of TCR affinities, we discovered that the functional responsiveness of any given TCR correlated with the contribution of CD8 to TCR/pMHC binding. …”
Publicado 2017
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14504por Qin, Xinmin, Guo, Yonghong, Du, Haoqi, Zhong, Yaogang, Zhang, Jiaxu, Li, Xuetian, Yu, Hanjie, Zhang, Zhiwei, Jia, Zhansheng, Li, Zheng“…Background: Chronic infection with HBV (CHB) or HCV (CHC) is the most common chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma in humans, their infections have distinct pathogenic processes, however, little is known about the difference of glycoprotein glycopatterns in serum between hepatitis B virus (HBV)- and hepatitis C virus (HCV)-infected patients. Methods: A method combining the lectin microarrays, letin-mediated affinity capture glycoproteins, and MALDI-TOF/TOF-MS was employed to analyze serum protein glycopatterns and identify the glycan structures from patients with CHB (n = 54) or CHC(n = 47), and healthy volunteers (HV, n = 35). …”
Publicado 2017
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14505por Ubillos, Itziar, Campo, Joseph J., Requena, Pilar, Ome-Kaius, Maria, Hanieh, Sarah, Rose, Honor, Samol, Paula, Barrios, Diana, Jiménez, Alfons, Bardají, Azucena, Mueller, Ivo, Menéndez, Clara, Rogerson, Stephen, Moncunill, Gemma, Dobaño, Carlota“…In persistent infections that are accompanied by chronic immune activation, such as human immunodeficiency virus, hepatitis C virus, and malaria, there is an increased frequency of a phenotypically distinct subset of memory B cells lacking the classic memory marker CD27 and showing a reduced capacity to produce antibodies. …”
Publicado 2017
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14506“…BACKGROUND: Liver disease due to hepatitis B (HBV) and hepatitis C (HCV) is becoming the largest cause of death in HIV+ individuals worldwide. …”
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14507por Mankame, Siddhi, Niknam, Negin, Elfekey, Mohammed, Schwartz, Rebecca, Rasul, Rehana, Hirsch, Bruce, Mcgowan, Joseph“…Some patients with long-term viral suppression never adequately recover their CD4+ count and manifest increased mortality. Age, CD4+ nadir, Hepatitis C infection have been associated with incomplete immune recovery. …”
Publicado 2017
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14508por Veve, Michael P, Morin, Amy, Kenney, Rachel M, Makowski, Charles T, Davis, Susan L“…Of 421 orders for antivirals, indication was: 53% for hepatitis C. Thirty-seven percent of orders were for 1 day only, suggesting continued use outpatient. 3% of orders had an extended duration of therapy > 14 days. 185 orders were placed for new drugs (within 12 months of FDA-approval), 73% were for HIV agents. 11 of 44 NF agents were subsequently added to the formulary. …”
Publicado 2017
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14509por Kirk, Gregory D., Dandorf, Stewart, Li, Huifen, Chen, Yiyin, Mehta, Shruti H., Piggott, Damani A., Margolick, Joseph B., Leng, Sean X.“…Multivariate regression analyses were employed, adjusting for age, sex, body mass index, smoking, hepatitis C virus co-infection, injection drug use, comorbidities, and HIV status (for all participants), and HIV viral load, CD4(+) T-cell counts, and antiretroviral therapy (for HIV+ participants). …”
Publicado 2017
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14510por Kamada, Yoshihiro, Ono, Masafumi, Hyogo, Hideyuki, Fujii, Hideki, Sumida, Yoshio, Yamada, Makoto, Mori, Kojiroh, Tanaka, Saiyu, Maekawa, Tomohiro, Ebisutani, Yusuke, Yamamoto, Akiko, Takamatsu, Shinji, Yoneda, Masashi, Kawada, Norifumi, Chayama, Kazuaki, Saibara, Toshiji, Takehara, Tetsuo, Miyoshi, Eiji“…Wisteria floribunda agglutinin (WFA)‐positive Mac‐2bp (WFA(+)‐M2BP) is a novel serum fibrosis biomarker for chronic hepatitis C that has clinical validity. Mac‐2bp and WFA(+)‐M2BP are also clinical NAFLD biomarker candidates. …”
Publicado 2017
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14511por Tayob, Nabihah, Richardson, Peter, White, Donna L., Yu, Xiaoying, Davila, Jessica A., Kanwal, Fasiha, Feng, Ziding, El-Serag, Hashem B.“…METHODS: We used electronic medical records from the Department of Veterans Affairs Hepatitis C Clinical Case Registry to construct our analysis cohort, which consists of serial AFP tests in 11,222 cirrhosis control patients and 902 HCC cases prior to their HCC diagnosis. …”
Publicado 2018
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14512por Costa, Marisa Boff, Picon, Paulo Dornelles, Sander, Guilherme Becker, Cuni, Hugo Nodarse, Silva, Carmen Valenzuela, Meireles, Rolando Páez, Góes, Ana Carolina Magalhães Andrade, Batoreu, Nadia Maria, Maia, Maria de Lourdes de Sousa, Albuquerque, Elizabeth Maciel, Matos, Denise Cristina de Souza, Saura, Pedro Lopez“…A phase II-III repeated-dose clinical trial is ongoing to study these findings in patients with chronic hepatitis C virus infection. TRIAL REGISTRATION: This study is registered on the ClinicalTrials.gov platform (accession number NCT01889849). …”
Publicado 2018
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14513por Berenguer, Juan, Jarrín, Inmaculada, Pérez-Latorre, Leire, Hontañón, Víctor, Vivancos, María J, Navarro, Jordi, Téllez, María J, Guardiola, Josep M, Iribarren, José A, Rivero-Juárez, Antonio, Márquez, Manuel, Artero, Arturo, Morano, Luis, Santos, Ignacio, Moreno, Javier, Fariñas, María C, Galindo, María J, Hernando, María A, Montero, Marta, Cifuentes, Carmen, Domingo, Pere, Sanz, José, Domíngez, Lourdes, Ferrero, Oscar L, De la Fuente, Belén, Rodríguez, Carmen, Reus, Sergio, Hernández-Quero, José, Gaspar, Gabriel, Pérez-Martínez, Laura, García, Coral, Force, Lluis, Veloso, Sergio, Losa, Juan E, Vilaró, Josep, Bernal, Enrique, Arponen, Sari, Ortí, Amat J, Chocarro, Ángel, Teira, Ramón, Alonso, Gerardo, Silvariño, Rafael, Vegas, Ana, Geijo, Paloma, Bisbe, Josep, Esteban, Herminia, González-García, Juan“…BACKGROUND: We assessed the prevalence of antibodies against hepatitis C virus (HCV-Abs) and active HCV infection in patients infected with human immunodeficiency virus (HIV) in Spain in 2016 and compared the results with those of similar studies performed in 2002, 2009, and 2015. …”
Publicado 2018
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14514por Akiyama, Matthew J., Agyemang, Linda, Arnsten, Julia H., Heo, Moonseong, Norton, Brianna L., Schackman, Bruce R., Linas, Benjamin P., Litwin, Alain H.“…BACKGROUND: People who inject drugs (PWID) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). Treatment of PWID is complex due to addiction, mental illness, poverty, homelessness, lack of positive social support, poor adherence-related skills, low motivation and knowledge, and poor access to and trust in the health care system. …”
Publicado 2018
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14515por Hanlon, Peter, Yeoman, Lynsey, Gibson, Lauren, Esiovwa, Regina, Williamson, Andrea E, Mair, Frances S, Lowrie, Richard“…Studies included various NCDs (n=3); or focused on latent tuberculosis (n=4); HIV (n=2); hepatitis C (n=1) or type 2 diabetes (n=1). All interventions were complex with multiple components. …”
Publicado 2018
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14516“…More than 90 % of governments reported having national surveillance systems for the acute forms of hepatitis B and hepatitis C, but less than two-thirds reported surveillance for the chronic forms of both diseases. …”
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14517por Alavi, Maryam, Grebely, Jason, Hajarizadeh, Behzad, Amin, Janaki, Larney, Sarah, Law, Matthew G., George, Jacob, Degenhardt, Louisa, Dore, Gregory J.“…BACKGROUND: This study evaluated cause-specific mortality trends including liver-related mortality among people with a hepatitis B virus (HBV) and hepatitis C virus (HCV) notification in New South Wales, Australia. …”
Publicado 2018
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14518“…Hepatitis C virus (HCV)-infected liver cells sensitize host cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell apoptosis; however, the precise mechanisms are unknown. …”
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14519por Ferreira-Júnior, Orlando da Costa, Guimarães, Mark Drew Crosland, Damacena, Giseli Nogueira, de Almeida, Wanessa da Silva, de Souza-Júnior, Paulo Roberto Borges, Szwarcwald, Célia Landmann“…In this paper, we estimate the prevalence of human immunodeficiency virus (HIV), HBV = hepatitis B virus (HBV), HCV = hepatitis C virus (HCV), syphilis and co-infections in the second Biological and Behavioral Surveillance Survey among FSW in Brazil. …”
Publicado 2018
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14520por Gagliardini, Roberta, Ciccullo, Arturo, Borghetti, Alberto, Maggiolo, Franco, Bartolozzi, Dario, Borghi, Vanni, Pecorari, Monica, Di Biagio, Antonio, Callegaro, Anna Paola, Bruzzone, Bianca, Saladini, Francesco, Paolucci, Stefania, Maserati, Renato, Zazzi, Maurizio, Di Giambenedetto, Simona, De Luca, Andrea“…Patients with M184V (n = 87) were older, had lower nadir CD4+ cell count, longer duration of antiretroviral therapy and of virologic suppression, and higher rate of hepatitis C virus infection compared with patients without M184V. …”
Publicado 2018
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