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2021por Rinnerthaler, Gabriel, Singer, Christian, Petru, Edgar, Egle, Daniel, Petzer, Andreas, Pluschnig, Ursula, Gampenrieder, Simon Peter, Pfeiler, Georg, Gnant, Michael, Grünberger, Birgit, Krippl, Peter, Strasser-Weippl, Kathrin, Suppan, Christoph, Brunner, Christine, Pusch, Renate, Sandholzer, Margit, Balic, Marija, Bartsch, Rupert“…In the past 12 months a plethora of relevant novel data for the treatment of metastatic HER2 positive breast cancer were published. To bring this new evidence into a clinical perspective, a group of Austrian breast cancer specialists updated their previously published treatment algorithm for those patients. …”
Publicado 2022
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2022por Dowsett, Mitch, Kilburn, Lucy, Rimawi, Mothaffar F., Osborne, C. Kent, Pogue-Geile, Katherine, Liu, Yuan, Jacobs, Samuel A., Finnigan, Melanie, Puhalla, Shannon, Dodson, Andrew, Martins, Vera, Cheang, Maggie, Perry, Sophie, Holcombe, Chris, Turner, Nick, Swift, Claire, Bliss, Judith M., Johnston, Stephen“…PURPOSE: To determine (i) the relationship between candidate biomarkers of the antiproliferative (Ki67) response to letrozole and palbociclib alone and combined in ER(+)/HER2(−) breast cancer; and (ii) the pharmacodynamic effect of the agents on the biomarkers. …”
Publicado 2022
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2023por Jiaxin, Chen, Jinmei, Zhou, Huiqiang, Zhang, Xuexue, Wu, Xiaobo, Wang, Shaohua, Zhang, Yanhong, Tai, Zefei, Jiang, Tao, Wang“…RESULTS: The conversion rate of anyone receptor (ER, PR, or HER2) between the primary lesions and brain metastatic lesions was 45.0% (18/40), of which the ER inconsistency rate was 25.0%, the PR inconsistency rate was 22.5%, and the HER-2 inconsistency rate was 15.0%, and the receptor conversion resulted in a subtype conversion of 27.5% (11/40). …”
Publicado 2022
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2024por Fogazzi, Valentina, Kapahnke, Marcel, Cataldo, Alessandra, Plantamura, Ilaria, Tagliabue, Elda, Di Cosimo, Serena, Cosentino, Giulia, Iorio, Marilena V.“…SIMPLE SUMMARY: Breast cancer is the most diagnosed malignancy in woman worldwide and, despite the availability of new innovative therapies, it remains the first cause of death for tumor in woman. 20% of all breast cancer cases are HER2 positive, meaning that they are characterized by an aberrant expression of the growth factor receptor HER2. …”
Publicado 2022
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2025por Vaid, Ashok, T., Raja, Batra, Ullas, Krishna, Vamshi Muddu, Rangrajan, Bharath, Narayanan, Prasad, Vora, Amish, Advani, Suresh H.Enlace del recurso
Publicado 2022
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2026
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2027por Xue, Cong, Li, Haifeng, Yao, Herui, Lin, Ying, An, Xin, Chen, Meiting, Huang, Riqing, Li, Lu, Hu, Anqi, Ni, Mengqian, Zhang, Lulu, Yang, Wei, Xu, Zhonghui, Li, Su, Shi, Yanxia“…The prognosis of human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer (MBC) remained unsatisfactory currently, more anti-HER2 agents are needed. …”
Publicado 2022
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2028por Kuznetsov, Vitalii, Lu, Leran, Koza, Michael M., Rogalla, Detlef, Foteinou, Varvara, Becker, Hans-Werner, Nefedov, Alexei, Traeger, Franziska, Fouquet, PeterEnlace del recurso
Publicado 2022
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2029por Alasmari, Moudi M.“…SIMPLE SUMMARY: HER2+ metastatic breast cancer (MBC) is a highly prevalent type of breast cancer owing to its resistance to conventional anti-HER2 drugs. …”
Publicado 2022
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2030“…Among them, the Human epidermal growth factor receptor 2 (HER2) is an important therapeutic target. With the continuous optimization of chemotherapeutic drugs and chemotherapy regimens, the prognosis of some HER2-positive GC patients has been greatly improved. …”
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2031por You, Daeun, Kim, Hyungjoo, Jeong, Yisun, Yoon, Sun Young, Lo, Eunji, Kim, Sangmin, Lee, Jeong Eon“…It was found that the co-expression of EGFR and HER2 was associated with a worse prognosis. Therefore, we generated EGFR-positive BLBC cells with stable HER2 overexpression and analyzed the profile of secretory cytokines. …”
Publicado 2023
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2032por Chen, Aolei, Ye, Shaotang, Zheng, Jiahui, Li, Jichao, Chen, Zejia, Zhang, Yashan, Li, Shoujun“…Inoculation of CMT-1 cells induced a complex HER2-enriched mammary tumor with metastasis in mice. …”
Publicado 2023
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2033por Cavalieri, Stefano, Nuzzolese, Imperia, Ottini, Arianna, Bergamini, Cristiana, Resteghini, Carlo, Colombo, Elena, Alfieri, Salvatore, Quattrone, Pasquale, Calareso, Giuseppina, Iacovelli, Nicola Alessandro, Franceschini, Marzia, Licitra, Lisa“…Median follow-up was 36.18 months (95% CI 30.19-42.66). HER2 status was available in 62 cases (84%) and in 42% the protein was overexpressed (HER2+). …”
Publicado 2023
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2034
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2035por Gonçalves, Juliana Pereira Lopes, Bollwein, Christine, Noske, Aurelia, Jacob, Anne, Jank, Paul, Loibl, Sibylle, Nekljudova, Valentina, Fasching, Peter A., Karn, Thomas, Marmé, Frederik, Müller, Volkmar, Schem, Christian, Sinn, Bruno Valentin, Stickeler, Elmar, van Mackelenbergh, Marion, Schmitt, Wolfgang D., Denkert, Carsten, Weichert, Wilko, Schwamborn, KristinaEnlace del recurso
Publicado 2023
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2036por Yang, Zheng‐Jun, Liu, Yu‐Xiao, Huang, Yue, Chen, Zu‐Jin, Zhang, Hao‐Zhi, Yu, Yue, Wang, Xin, Cao, Xu‐Chen“…METHODS: In this study, we retrospectively reviewed the data of 1603 patients who were diagnosed with HER2‐negative breast invasive ductal carcinoma. …”
Publicado 2022
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2037por Waliany, Sarah, Caswell-Jin, Jennifer, Riaz, Fauzia, Myall, Nathaniel, Zhu, Han, Witteles, Ronald M., Neal, Joel W.“…Heart failure (HF) risks from other anti-HER2 therapies are less clear. OBJECTIVES: Using World Health Organization pharmacovigilance data, the authors compared HF odds across anti-HER2 regimens. …”
Publicado 2023
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2038por Shang, Jiuyan, Sun, Xuemei, Xu, Zihang, Cai, Lijing, Liu, Chang, Wu, Si, Liu, Yueping“…BACKGROUND: The emergence of HER2 antibody-drug conjugates provides new treatment decisions for breast cancer patients, especially those with HER2-low expression. …”
Publicado 2023
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2039por Yang, Ziyan, Feng, Jianguo, Jing, Ji, Huang, Yuan, Ye, Wei-Wu, Lei, Lei, Wang, Xiao-Jia, Cao, Wen-Ming“…HER2-positive breast cancer patients carrying the germline TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) are resistant to anti-HER2 therapy. …”
Publicado 2023
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2040por Piha-Paul, Sarina A., Tseng, Chieh, Tran, Hai T., Gao, Meng, Karp, Daniel D., Subbiah, Vivek, Tsimberidou, Apostolia Maria, Kawedia, Jitesh D., Fu, Siqing, Pant, Shubham, Yap, Timothy A., Morris, Van K., Kee, Bryan K., Blum Murphy, Mariela, Lim, JoAnn, Meric-Bernstam, Funda“…Herein, we sought to determine the feasibility and safety of neratinib and trametinib in patients with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation and KRAS mutation. …”
Publicado 2023
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