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2081por Wang, Stacie S, Davenport, Alexander J, Iliopoulos, Melinda, Hughes-Parry, Hannah E, Watson, Katherine A, Arcucci, Valeria, Mulazzani, Matthias, Eisenstat, David D, Hansford, Jordan R, Cross, Ryan S, Jenkins, Misty R“…Furthermore, HER2 CAR T cells provided a significant regression in intracranial DIPG xenograft tumors. …”
Publicado 2023
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2082“…SIMPLE SUMMARY: The development of drug resistance in HER2 targeted therapies poses a major challenge in breast cancer treatment. …”
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2083“…The HER2-low paradigm has challenged the traditional understanding of HER2 overexpression and emphasized the need for more robust HER2 testing in order to encompass HER2 intratumoral heterogeneity and spatial distribution more accurately. …”
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2084Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancerpor Liu, Qian, Huang, Shujun, Desautels, Danielle, McManus, Kirk J., Murphy, Leigh, Hu, Pingzhao“…BACKGROUND: Human epidermal growth receptor 2-positive (HER2+) breast cancer (BC) is a heterogeneous subgroup. …”
Publicado 2023
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2085por Otchere, Prince, Adekoya, Olusola, Governor, Samuel B., Vuppuluri, Naveen, Prabhakar, Akruti, Pak, Stella, Oppong-Nkrumah, Oduro, Cook, Francis, Bohinc, Rudy, Aune, Gregory“…BACKGROUND: 25% of all breast cancer patients have HER-2 overexpression. Breast Cancer patients with HER-2 overexpression are typically treated with HER-2 inhibitors such as Trastuzumab. …”
Publicado 2023
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2086por Teruya, Natsuki, Inoue, Hiroaki, Horii, Rie, Akiyama, Futoshi, Ueno, Takayuki, Ohno, Shinji, Takahashi, Shunji“…BACKGROUND: ER+HER2+ breast cancer requires most types of systemic therapies perioperatively. …”
Publicado 2023
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2087por Boșoteanu, Luana-Andreea, Așchie, Mariana, Orǎșanu, Cristian Ionuţ, Boșoteanu, Mădălina“…The unexpected negative HER2 reaction is conducted to a primary focus on excluding a malignant melanoma in situ. …”
Publicado 2023
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2088“…We conducted a meta-analysis to systematically evaluate the efficacy and safety of treatment with or without pertuzumab for human epidermal growth factor receptor-2 -positive (HER2)-positive breast cancer and provided evidence-based reference for clinical use. …”
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2089“…A total of 44 patients (12.6%) had HER2 loss. HER2 status (immunohistochemistry (IHC) 3+ vs. …”
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2090por Yang, Ziguo, Sun, Rencheng, Qu, Gengbao, Wang, Feng, Yin, Ziyi, Zhang, Tie, Wang, Pilin, Li, Shaoxiang, Lin, Shuye“…METHODS: In this study, in-depth analysis of the microarray data from the GSE43837 dataset with 19 BM samples of HER2-positive BC patients and 19 HER2-positive nonmetastatic primary BC samples was conducted. …”
Publicado 2023
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2091
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2092por Liefaard, M. C., van der Voort, A., van Ramshorst, M. S., Sanders, J., Vonk, S., Horlings, H. M., Siesling, S., de Munck, L., van Leeuwen, A. E., Kleijn, M., Mittempergher, L., Kuilman, M. M., Glas, A. M., Wesseling, J., Lips, E. H., Sonke, G. S.“…METHODS: From a cohort of patients with stage II-III HER2-positive breast cancer who were treated with neoadjuvant chemotherapy and trastuzumab with or without pertuzumab, 836 patients were selected for microarray gene expression analysis, followed by readout of BluePrint standard (HER2, Basal and Luminal) and dual subtypes (HER2-single, Basal-single, Luminal-single, HER2-Basal, Luminal-HER2, Luminal-HER2-Basal). …”
Publicado 2023
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2093por Xu, Bin, Chen, Hui, Zhang, Jingjing, Cong, Yanghai, Ning, Li, Chen, Limin, Zhang, Yushi, Zhang, Yong, Song, Zhanchun, Meng, Yuan, He, Lianqi, Liao, Wei-li, Lu, Ying, Zhao, Fengyi“…INTRODUCTION: Gastric cancer is a highly heterogeneous malignant tumor of the digestive system. Anti-HER2 treatment can inhibit downstream signaling pathways and improve clinical treatment and outcomes in patients with HER2 protein overexpression. …”
Publicado 2023
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2094por Derme, Martina, Piccioni, Maria Grazia, Brunelli, Roberto, Crognale, Alba, Denotti, Marika, Ciolli, Paola, Scomparin, Debora, Tarani, Luigi, Paparella, Roberto, Terrin, Gianluca, Di Chiara, Maria, Mattia, Alessandro, Nicotera, Simona, Salomone, Alberto, Ceccanti, Mauro, Messina, Marisa Patrizia, Maida, Nunzia La, Ferraguti, Giampiero, Petrella, Carla, Fiore, Marco“…We also found that the mother during pregnancy was a cocaine abuser. As a result, her newborn was diagnosed with fetal alcohol syndrome (FAS). …”
Publicado 2023
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2095“…The main goal of the present study was to examine if the RNA-sequencing (RNAseq)-based ERBB2/HER2 expression level in malignant plasma cells from multiple myeloma (MM) patients has clinical significance for treatment outcomes and survival. …”
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2096por Castrignano, Chiara, Di Scipio, Federica, Franco, Francesco, Mognetti, Barbara, Berta, Giovanni Nicolao“…Here, we provide an overview of the notable structural and biochemical characteristics of NBs, particularly in their application against HER2, an extracellular receptor that often gets aberrantly activated during breast cancer tumorigenesis. …”
Publicado 2023
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2097
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2098por Morganti, Stefania, Bychkovsky, Brittany L, Poorvu, Philip D, Garrido-Castro, Ana C, Weiss, Anna, Block, Caroline C, Partridge, Ann H, Curigliano, Giuseppe, Tung, Nadine M, Lin, Nancy U, Garber, Judy E, Tolaney, Sara M, Lynce, Filipa“…The benefit was consistent across subgroups, and this regimen is now recommended after chemotherapy for germline BRCA1/2 mutation (gBRCA1/2m) carriers with high-risk, HER2-negative early breast cancer. However, the integration of olaparib in the landscape of agents currently available in the post(neo)adjuvant setting—ie, pembrolizumab, abemaciclib, and capecitabine—is challenging, as there are no data suggesting how to select, sequence, and/or combine these therapeutic approaches. …”
Publicado 2023
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2099“…In addition, to fully consider the individual and panel diagnosis opinions, we propose a new loss function called collaborative loss, which can collaboratively optimize the individual and her peers’ opinions to provide a more accurate diagnosis. …”
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2100por Lyu, Hui, Hou, Defu, Liu, Hao, Ruan, Sanbao, Tan, Congcong, Wu, Jiande, Hicks, Chindo, Liu, Bolin“…Inactivation of HER3 combined with panobinostat represents a practical approach to combat CL TNBC.…”
Publicado 2023
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