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2121“…INTRODUCTION: Overexpression of the HER2/neu gene in breast cancer is associated with an increased incidence of metastatic disease and with a poor prognosis. …”
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2122por Huang, Jie, Zhu, Wenqiang, Duan, Qiangzhi, Zhu, Chaomang, Shi, Xueling, Zhao, Hongyu, Cai, Peng, Li, Duojie“…PURPOSE: To explore the efficacy and safety of pyrotinib combined with different radiotherapy modes in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) patients with brain metastasis (BM). …”
Publicado 2023
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2123por Zheng, Rui, Chen, Yuankun, Zhang, Yiting, Liang, Sixin, Zhao, Xiaojuan, Wang, Yiyi, Wang, Pengju, Meng, Ruotong, Yang, Angang, Yan, Bo“…METHODS: We used different humanized anti-HER2 antibodies as the extracellular domain of CARs and further constructed a series of the CAR-T cells with different affinity. …”
Publicado 2023
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2124Liquid biopsy based HER2 amplification status in gastric cancer patients indicates clinical responsepor Klein-Scory, Susanne, Ladigan-Badura, Swetlana, Mika, Thomas, Verdoodt, Berlinda, Tannapfel, Andrea, Pohl, Michael, Schroers, Roland, Baraniskin, Alexander“…However, HER2 amplification is detectable in only about 20 % of gastric carcinomas. …”
Publicado 2023
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2125por Arteaga, Carlos L“…Overexpression of the HER2/Neu (ErbB2) proto-oncogene is associated with breast cancer progression and poor patient prognosis. …”
Publicado 2003
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2126por Hanna, W., O’Malley, F.P., Barnes, P., Berendt, R., Gaboury, L., Magliocco, A., Pettigrew, N., Robertson, S., Sengupta, S., Têtu, B., Thomson, T.“…Testing for her2/neu in breast cancer at the time of primary diagnosis is now the standard of care. …”
Publicado 2007
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2127
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2128Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells.por Tagliabue, E., Ardini, E., Pellegrini, R., Campiglio, M., Bufalino, R., Jeschke, M., Groner, B., Colnaghi, M. I., Ménard, S.“…Laminin also specifically inhibited growth of p185HER2-positive cell lines. No direct binding between the recombinant extracellular domain of p185HER2 and laminin was found. …”
Publicado 1996
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2129Publicado 1992“…The HER2 protooncogene encodes a 185-kD transmembrane phosphoglycoproteins, human epidermal growth factor receptor 2 (p185HER2), whose amplified expression on the cell surface can lead to malignant transformation. …”
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2130“…INTRODUCTION: Accurate determination of human epidermal growth factor receptor 2 (HER2) status is essential for optimal patient management with trastuzumab (Herceptin). …”
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2131por van de Vijver, Marc, Bilous, Michael, Hanna, Wedad, Hofmann, Manfred, Kristel, Petra, Penault-Llorca, Frédérique, Rüschoff, Josef“…Inter-laboratory concordance was also very high: 95% for normal HER2 copy number (1–5 copies); and 92% for cases with HER2 copy numbers ≥ 6. …”
Publicado 2007
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2132por Asgeirsson, Kristjan S, Agrawal, Amit, Allen, Claire, Hitch, Anthony, Ellis, Ian O, Chapman, Caroline, Cheung, Kwok L, Robertson, John FR“…In 18 patients (32%) HER2 expression changed from normal to over-expression. …”
Publicado 2007
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2133por Bruynzeel, A M E, Abou El Hassan, M A, Schalkwijk, C, Berkhof, J, Bast, A, Niessen, H W M, van der Vijgh, W J F“…These effects were compared with those of the potential cardioprotector 7-monohydroxyethylrutoside (monoHER). BALB/c mice were treated with saline, DOX alone or DOX preceded by ketoprofen (KP), dexamethasone (DEX) or monoHER. …”
Publicado 2007
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2134“…Skin toxicity, a common drug-related adverse event observed in cancer patients treated with epidermal growth factor receptor (EGFR)-directed therapies is rarely seen with therapies targeting HER2. This study reports the significance of the EGFR and HER2 dimerization status in skin with regard to these dermatologic side effects. …”
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2135por Arnould, L, Gelly, M, Penault-Llorca, F, Benoit, L, Bonnetain, F, Migeon, C, Cabaret, V, Fermeaux, V, Bertheau, P, Garnier, J, Jeannin, J-F, Coudert, B“…Potential cytolytic cells were stained for Granzyme B and TiA1. HER2 expression was also evaluated in residual tumour cells. …”
Publicado 2006
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2136por Del Mastro, L, Bruzzi, P, Nicolò, G, Cavazzini, G, Contu, A, D'Amico, M, Lavarello, A, Testore, F, Castagneto, B, Aitini, E, Perdelli, L, Bighin, C, Rosso, R, Venturini, Marco“…No data are available on the role of HER2 overexpression in predicting the efficacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients. …”
Publicado 2005
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2137por Cappuzzo, F, Toschi, L, Domenichini, I, Bartolini, S, Ceresoli, G L, Rossi, E, Ludovini, V, Cancellieri, A, Magrini, E, Bemis, L, Franklin, W A, Crino, L, Bunn, P A, Hirsch, F R, Varella-Garcia, M“…No difference in response was observed according to HER3 status in patients with EGFR+ tumours. Patients with HER2+/HER3+ tumours had similar outcome as patients with HER2− and/or HER3− tumours. …”
Publicado 2005
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2138por Wu, Yanyuan, Mohamed, Hezla, Chillar, Ram, Ali, Ishrat, Clayton, Sheila, Slamon, Dennis, Vadgama, Jaydutt V“…INTRODUCTION: Breast cancer patients with HER2/neu overexpression have poor outcomes with a decrease in disease-free survival (DFS) and overall survival. …”
Publicado 2008
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2139por Hirsch, F R, Varella-Garcia, M, Franklin, W A, Veve, R, Chen, L, Helfrich, B, Zeng, C, Baron, A, Bunn, P A“…HER-2/neu gene amplification and cell surface overexpression are important factors in breast cancer for prognosis and prediction of sensitivity to anti-HER-2/neu monoclonal antibody therapy. …”
Publicado 2002
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2140por Meert, A-P, Martin, B, Paesmans, M, Berghmans, T, Mascaux, C, Verdebout, J-M, Delmotte, P, Lafitte, J-J, Sculier, J-PEnlace del recurso
Publicado 2003
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