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2261por Lindsten, Therése, Hedbrant, Alexander, Ramberg, Anna, Wijkander, Jonny, Solterbeck, Anja, Eriksson, Margareta, Delbro, Dick, Erlandsson, Ann“…No significant association could be seen between the level of macrophage and HER-2, ERβ1 or MMP-9 expression. Effect of conditioned media (CM) generated from cultured human M1 and M2 macrophage phenotypes were investigated on the proliferation and expression of selected markers in the T47D breast cancer cell line. …”
Publicado 2017
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2262
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2263“…The present study explores the correlation of human epidermal growth factor receptor-2 (HER-2) protein expression with sentinel lymph node (SLN) metastasis and prognosis of breast cancer. …”
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2264por Ji, Changfeng, Zhang, Qinglei, Guan, Wenxian, Guo, Tingting, Chen, Ling, Liu, Song, He, Jian, Zhou, Zhengyang“…The ADC and D values of HER2 positive gastric cancers were significantly higher than those of HER2 negative tumors (P = 0.033, 0.007, respectively). …”
Publicado 2017
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2265por Saleem, Azeem, Searle, Graham E., Kenny, Laura M., Huiban, Mickael, Kozlowski, Kasia, Waldman, Adam D., Woodley, Laura, Palmieri, Carlo, Lowdell, Charles, Kaneko, Tomomi, Murphy, Philip S., Lau, Mike R., Aboagye, Eric O., Coombes, Raoul C.Enlace del recurso
Publicado 2017
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2266por Suh, Koung Jin, Sung, Ji Hea, Kim, Jin Won, Han, Song-Hee, Lee, Hye Seung, Min, Ahrum, Kang, Mi Hyun, Kim, Ji Eun, Kim, Ji-Won, Kim, Se Hyun, Lee, Jeong-Ok, Kim, Yu Jung, Lee, Keun-Wook, Kim, Jee Hyun, Bang, Soo-Mee, Im, Seock-Ah, Lee, Jong Seok“…BACKGROUND: Characteristics of tumor microenvironment have been suggested as predictive markers of anti-EGFR or anti-HER2 treatment response. However, the effect of EGFR/HER2 signal blockade on the tumor immune microenvironment is unclear. …”
Publicado 2017
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2267
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2268por Tolmachev, Vladimir, Yim, Cheng-Bin, Rajander, Johan, Perols, Anna, Karlström, Amelie Eriksson, Haaparanta-Solin, Merja, Grönroos, Tove J., Solin, Olof, Orlova, Anna“…Imaging using affibody molecules enables discrimination between breast cancer metastases with high and low expression of HER2, making appropriate therapy selection possible. …”
Publicado 2017
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2269“…The development of targeted toxins based on non-immunoglobulin targeting molecules appears to be one of the most advanced approaches in the targeted therapy of malignant tumors with a high expression of the HER2 receptor. Earlier, we showed that the targeted toxin DARPin-PE40 consisting of the HER2-specific non-immunoglobulin polypeptide (the targeting module) and a fragment of Pseudomonas exotoxin A (the toxic module) exhibits an antitumor effect in vivo against the HER2-positive adenocarcinoma xenograft. …”
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2270por Scala, Alessandra, Mirabella, Rossana, Goedhart, Joachim, de Vries, Michel, Haring, Michel A., Schuurink, Robert C.“…Knockdown and overexpression lines of HER2 confirmed the role of HER2, which encodes an oxidoreductase, in the responsiveness to E-2-hexenal. …”
Publicado 2017
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2271por Muntasell, Aura, Cabo, Mariona, Servitja, Sonia, Tusquets, Ignasi, Martínez-García, María, Rovira, Ana, Rojo, Federico, Albanell, Joan, López-Botet, Miguel“…Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup of breast tumors with aggressive behavior. …”
Publicado 2017
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2272por Guo, Peng, Pu, Tianjie, Chen, Shinan, Qiu, Yan, Zhong, Xiaorong, Zheng, Hong, Chen, Lina, Bu, Hong, Ye, Feng“…Among the 119 IDC patients evaluated, epidermal growth factor receptor [EGFR; also known as human epidermal growth factor receptor (HER)1], HER2, HER3 and HER4 gene amplification was observed in 30 (25.2%), 44 (36.9%), 0 (0.0%) and 1 (0.8%) patients, respectively. …”
Publicado 2017
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2273por Ahdash, Zainab, Lau, Andy M., Byrne, Robert Thomas, Lammens, Katja, Stüetzer, Alexandra, Urlaub, Henning, Booth, Paula J., Reading, Eamonn, Hopfner, Karl-Peter, Politis, Argyris“…The HerA–NurA helicase–nuclease complex cooperates with Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks. …”
Publicado 2017
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2274por Tajima, Jesse Yu, Futamura, Manabu, Gaowa, Siqin, Mori, Ryutaro, Tanahashi, Toshiyuki, Tanaka, Yoshihiro, Matsuhashi, Nobuhisa, Takahashi, Takao, Yamaguchi, Kazuya, Miyazaki, Tatsuhiko, Yoshida, Kazuhiro“…We previously reported cross-talk between GPNMB and human epidermal growth factor receptor 2 (HER2) in breast cancer, suggesting that GPNMB might play an important role in resistance to anti-HER2 therapy in breast cancer. …”
Publicado 2018
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2275por Ghatar, Reza Hosseini, Soltantoyeh, Tahereh, Bahadori, Tannaz, Golara, Maryam, Hassannia, Hadi, Eghbal, Roya Khosravi, Khoshnoodi, Jalal, Judaki, Mohammad Ali, Golsaz-Shirazi, Forough, Jeddi-Tehrani, Mahmood, Amiri, Mohammad Mehdi, Shokri, Fazel“…Cross-reactivity of the mAbs with other members of the human HER family and Cynomolgus HER2 was also studied by ELISA. …”
Publicado 2017
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2276
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2277“…BACKGROUND & OBJECTIVE: The HER-2 gene is an important on co protein overexpressed in many types of cancers. …”
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2278por Rahmani, Arshad H., Babiker, Ali Yousif, Alsahli, Mohammed A., Almatroodi, Saleh A., Husain, Nazik Elmalaika O. S.“…The expression level of Her-2 protein was not correlated with the stage of a tumour (p > 0.05). …”
Publicado 2018
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2279“…OBJECTIVE: The estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2) each play an important role in female cancers. …”
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2280por Floros, Konstantinos V., Lochmann, Timothy L., Hu, Bin, Monterrubio, Carles, Hughes, Mark T., Wells, Jason D., Morales, Cristina Bernadó, Ghotra, Maninderjit S., Costa, Carlotta, Souers, Andrew J., Boikos, Sosipatros A., Leverson, Joel D., Tan, Ming, Serra, Violeta, Koblinski, Jennifer E., Arribas, Joaquin, Prat, Aleix, Paré, Laia, Miller, Todd W., Dozmorov, Mikhail G., Harada, Hisashi, Windle, Brad E., Scaltriti, Maurizio, Faber, Anthony C.“…HER2 (ERBB2) amplification is a driving oncogenic event in breast cancer. …”
Publicado 2018
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