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2321por Aznab, Mozaffar, Maleksabet, Davood, Khazaei, Sedigheh, Khazaei, Mansour, Rezaei, Mansour“…Patients were assigned to two groups according to their HER2/neu status. First group included patients with positive HER2/neu (Score 3) and second group involved patients with negative HER2/neu (Score 0 and 1). …”
Publicado 2019
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2322“…BACKGROUND: This study will systematically investigate the efficacy and safety of the combination of pertuzumab, trastuzumab, and docetaxel (PTD) for treatment of patients with HER2-positive breast cancer (HER2-PBC). METHODS: A comprehensive literature search for this study will consist of 2 parts: electronic database records and gray literature. …”
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2323por Afrăsânie, Vlad-Adrian, Marinca, Mihai Vasile, Alexa-Stratulat, Teodora, Gafton, Bogdan, Păduraru, Marius, Adavidoaiei, Anca Maria, Miron, Lucian, Rusu, Cristina“…Two new biomarkers have recently been added to the metastatic colorectal cancer panel: HER2 and microsatellite instability. While HER2 is still being investigated in different prospective studies in order to validate its prognostic role, microsatellite instability already guides clinical decisions in substituted with advanced colorectal cancer. …”
Publicado 2019
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2324por Ilieva, Kristina M., Fazekas‐Singer, Judit, Bax, Heather J., Crescioli, Silvia, Montero‐Morales, Laura, Mele, Silvia, Sow, Heng Sheng, Stavraka, Chara, Josephs, Debra H., Spicer, James F., Steinkellner, Herta, Jensen‐Jarolim, Erika, Tutt, Andrew N. J., Karagiannis, Sophia N.Enlace del recurso
Publicado 2019
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2325por Bergamini, Cristiana, Cavalieri, Stefano, Sanguineti, Giuseppe, Farneti, Alessia, Licitra, Lisa“…Human epidermal growth factor 2 (HER2) can be amplified in a fraction of SDC. We describe the case of HER2+ metastatic SDC of the submandibular gland in a young pregnant woman treated by multimodal treatment (chemotherapy, radiotherapy and targeted therapy). …”
Publicado 2019
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2327por Zhang, Jie, Yin, Yan-Tao, Wu, Chi-Hua, Qiu, Rong-Lin, Jiang, Wen-Jun, Deng, Xiao-Geng, Li, Zhi-Xi“…Recently, HER2-positive breast cancer is often accompanied by poor prognosis of patients, and targeted therapy showed a promising prospect. …”
Publicado 2019
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2329por Maoz, Myriam, Devir, Michal, Inbar, Michal, Inbar-Daniel, Ziva, Sherill-Rofe, Dana, Bloch, Idit, Meir, Karen, Edelman, David, Azzam, Salah, Nechushtan, Hovav, Maimon, Ofra, Uziely, Beatrice, Kadouri, Luna, Sonnenblick, Amir, Eden, Amir, Peretz, Tamar, Zick, Aviad“…We examined five HER2+ cell lines, three HER2+ xenographs and 57 HER2+ tumor tissues. …”
Publicado 2019
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2330“…Approximately 50% of HER2 positive breast cancer cases are also estrogen receptor (ER) positive. …”
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2331Near-Infrared Photoimmunotherapy Using a Small Protein Mimetic for HER2-Overexpressing Breast Cancer“…In vitro, NIR-PIT using HER2 Affibody–IR700Dye conjugates induced the selective destruction of HER2-overexpressing breast cancer cells without damage to control cells having low level expression of HER2. …”
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2332por Sun, Bowen, Mason, Seth, Wilson, Robert C., Hazard, Starr E., Wang, Yubao, Fang, Rong, Wang, Qiwei, Yeh, Elizabeth S., Yang, Meixiang, Roberts, Thomas M., Zhao, Jean J., Wang, Qi“…Resistance of breast cancer to human epidermal growth factor receptor 2 (HER2) inhibitors involves reprogramming of the kinome through HER2/HER3 signaling via the activation of multiple tyrosine kinases and transcriptional upregulation. …”
Publicado 2019
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2333por Lee, Kangkook, Jung, Hyun Ae, Sun, Jong-Mu, Lee, Se-Hoon, Ahn, Jin Seok, Park, Keunchil, Ahn, Myung-Ju“…PURPOSE: Human epidermal growth factor receptor 2 (HER2) alterations are found in approximately 1%-3% of non-small cell lung cancers (NSCLCs). …”
Publicado 2020
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2334por Liu, Qi, Borcherding, Nicholas C., Shao, Peng, Maina, Peterson K., Zhang, Weizhou, Qi, Hank H.“…BACKGROUND: HER2 plays a critical role in tumourigenesis and is associated with poor prognosis of patients with HER2-positive breast cancers. …”
Publicado 2020
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2335por Hryciuk, Beata, Pęksa, Rafał, Bieńkowski, Michał, Szymanowski, Bartosz, Radecka, Barbara, Winnik, Kamil, Żok, Jolanta, Cichowska, Natalia, Iliszko, Mariola, Duchnowska, Renata“…No ERα expression was found in GBC and NT. Strong (3+) HER2 expression by IHC or HER2 amplification was seen in five GBC (10.4%). …”
Publicado 2020
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2336“…Expression profiles are very different, showing an intermediate position of the ER+/HER2− Basal subtype between the ER+/HER2− Luminal and ER− Basal subtypes, and let suggest a different cell-of-origin. …”
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2337por Takeda, Tatsuaki, Yamamoto, Hiromasa, Suzawa, Ken, Tomida, Shuta, Miyauchi, Shunsaku, Araki, Kota, Nakata, Kentaro, Miura, Akihiro, Namba, Kei, Shien, Kazuhiko, Soh, Junichi, Shien, Tadahiko, Kitamura, Yoshihisa, Sendo, Toshiaki, Toyooka, Shinichi“…Molecular‐targeted therapies directed against human epidermal growth factor receptor 2 (HER2) are evolving for various cancers. Neratinib is an irreversible pan‐HER tyrosine kinase inhibitor and has been approved by the FDA as an effective drug for HER2‐positive breast cancer. …”
Publicado 2020
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2338por Biri-Kovács, Beáta, Adorján, Afrodité, Szabó, Ildikó, Szeder, Bálint, Bősze, Szilvia, Mező, Gábor“…Human epidermal growth factor (HER2) is a transmembrane tyrosine kinase receptor that is frequently overexpressed in breast cancer. …”
Publicado 2020
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2339“…The development of CDK 4/6 inhibitors has dramatically changed the therapeutic management of hormone receptor-positive (HR+) and HER2 negative metastatic breast cancer (MBC). In combination with fulvestrant, palbociclib, ribociclib and abemaciclib have each been approved for HR+/HER2- MBC following the results of randomized Phase III studies (PALOMA-3, MONALEESA-3, MONARCH-2) and shown a significant advantage in PFS. …”
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2340por Rong, Lulu, Wang, Bingzhi, Guo, Lei, Liu, Xiuyun, Wang, Bingning, Ying, Jianming, Xue, Liyan, Lu, Ning“…However, literature on the frequency of HER2 expression in ESCC is scarce. In the present study, HER2 protein expression, HER2 gene amplification and the relationship between HER2 status and clinicopathological characteristics were evaluated in a large cohort of Chinese ESCC patients. …”
Publicado 2020
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