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2401por Egebjerg, Kristian, Harwood, Cecilie Dupont, Woller, Nina Claire, Kristensen, Claus Andrup, Mau-Sørensen, Morten“…BACKGROUND: HER2 aberrations in salivary gland carcinomas (SGC) as well as benefit of HER2 directed therapy have been reported in small studies. …”
Publicado 2021
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2402“…This review describes commonly used therapies for HER2-positive/HER2-overexpression patients and general relationship between genotypes of HER2, drug selection and final prognosis in order to provide suggestions for future diagnosis and treatment.…”
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2403
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2404por Groen, Emma J., van der Noordaa, Marieke E. M., Schaapveld, Michael, Sonke, Gabe S., Mann, Ritse M., van Ramshorst, Mette S., Lips, Esther H., Vrancken Peeters, Marie-Jeanne T. F. D., van Duijnhoven, Frederieke H., Wesseling, Jelle“…Therefore, we estimated the response of adjacent DCIS to NST-containing HER2-blockade in HER2-positive breast cancer patients and assessed the association of clinicopathological and radiological factors with response. …”
Publicado 2021
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2405HER2-positive adenocarcinoma arising from heterotopic pancreas tissue in the duodenum: A case reportpor Hirokawa, Yoshifumi S, Iwata, Takashi, Okugawa, Yoshinaga, Tanaka, Koji, Sakurai, Hiroyuki, Watanabe, Masatoshi“…Furthermore, to our knowledge, no HER2-positive cases in the duodenum have been reported in the scientific literature nor has the efficacy of trastuzumab treatment for the disease been reported. …”
Publicado 2021
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2406por Wu, Zhijun“…This paper is to provide a theoretical basis for the understanding of the scientific nature of social distancing by considering it as a social dilemma game played by every individual against his/her population. From this perspective, every individual needs to make a decision on how to engage in social distancing, or risk being trapped into a dilemma either exposing to deadly diseases or getting no access to necessary social activities. …”
Publicado 2021
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2407por Murray, Elisa, Cheng, Xiaoqing, Krishna, Anagha, Jin, Xiaohua, Ohara, Takahiro E., Stappenbeck, Thaddeus S., Bose, Ron“…BACKGROUND AND AIMS: The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. …”
Publicado 2021
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2408“…BACKGROUND: This study sought to examine the efficacy and adverse reactions of capecitabine and lobaplatin in the treatment of metastatic human epidermal growth factor receptor 2 (HER-2) negative breast cancer (BC). METHODS: This retrospective study examined 45 patients diagnosed with advanced HER-2 negative BC. …”
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2409por Yu, Xingfei, Wang, Chen, Zheng, Yabing, Miao, Beibei, Hu, Jiejie, Shao, Xiying, Sheng, Liming, Lin, Juan, Ding, Yuqin, Xuan, Haojun, Ding, Yingying, Gong, Lijie, Feng, Weiliang, Qin, Chengdong, Chen, Daobao, Yu, Yang, Yang, Hongjian“…PURPOSE: To compare survival in different strategies, preoperative systemic treatment versus upfront surgery, in HER2-positive early breast cancer patients in the real world. …”
Publicado 2021
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2410“…CASE PRESENTATION: A 51-year-old woman presented with a lump in her left breast and swollen lymph nodes in her left axilla and infraclavicular fossa. …”
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2411por Ning, Gang, Zhu, Qihui, Kang, Wonyoung, Lee, Hamin, Maher, Leigh, Suh, Yun-Suhk, Michaud, Michael, Silva, Mayerlin, Kwon, Jee Young, Zhang, Chengsheng, Lee, Charles“…Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 13–23% of all GC cases and patients with HER2 overexpression exhibit a poor prognosis. …”
Publicado 2021
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2412“…METHODS: 32 women diagnosed with primary HER2-positive breast cancer were recruited in this study. …”
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2413“…This study investigated the clinical characteristics and nomogram-predicted survival of patients with HER2-positive breast cancer. MATERIALS AND METHODS: Data on patients with HER2-positive breast cancer were retrieved from the Surveillance, Epidemiology, and End Results database. …”
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2414por Fujimoto, Akihiro, Matsuura, Kazuo, Kawasaki, Tomonori, Ichinose, Yuki, Nukui, Asami, Hiratsuka, Miyuki, Asano, Aya, Shimada, Hiroko, Osaki, Akihiko, Saeki, Toshiaki“…Breast cancer arising from fibroadenoma (FA) is rare, in which almost all reported cases are human epidermal growth factor receptor 2 (HER2)-negative. This is the first report to describe a case of HER2-positive breast cancer arising from FA that was treated with chemotherapy plus anti-HER2 therapy. …”
Publicado 2021
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2415por You, Zicong, Zhou, Weijun, Weng, Junyan, Feng, Haizhan, Liang, Peiqiao, Li, Yuhua, Shi, Fujun“…BACKGROUND: The E75 and GP2 vaccines are the few therapeutic vaccines targeting HER2 currently under clinical research for patients with breast cancer. …”
Publicado 2021
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2416por Ni, Hua, Kumbrink, Jörg, Mayr, Doris, Seiler, Alina, Hagemann, Friederike, Degenhardt, Tom, Sagebiel, Sabine, Würstlein, Rachel, Kates, Ronald, Harbeck, Nadia, Eggersmann, Tanja K.“…Molecular factors that drive metastasis in premenopausal patients with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2−), early breast cancer (EBC) are largely unknown. …”
Publicado 2021
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2417por Kearney, Matthew, Franks, Lauren, Lee, Shing, Tiersten, Amy, Makower, Della F, Cigler, Tessa, Mundi, Prabhjot, Chi, Dow-Chung, Goel, Anupama, Klein, Pam, Andreopoulou, Eleni, Sparano, Joseph, Trivedi, Meghna, Accordino, Melissa, Califano, Andrea, Hershman, Dawn L, Silva, Jose, Kalinsky, Kevin“…PURPOSE: Preclinical data demonstrate STAT3 as an important regular in HER2+ tumors, and disruption of the IL6-JAK2-STAT-S100A8/S100A9 signaling cascade reduces HER2+ cell viability. …”
Publicado 2021
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2418por Zhang, Wei, Bhagwath, Ankur S., Ramzan, Zeeshan, Williams, Taylor A., Subramaniyan, Indhumathy, Edpuganti, Vindhya, Kallem, Raja Reddy, Dunbar, Kerry B., Ding, Peiguo, Gong, Ke, Geurkink, Samuel A., Beg, Muhammad S., Kim, James, Zhang, Qiuyang, Habib, Amyn A., Choi, Sung-Hee, Lapsiwala, Ritu, Bhagwath, Gayathri, Dowell, Jonathan E., Melton, Shelby D., Jie, Chunfa, Putnam, William C., Pham, Thai H., Wang, David H.“…Lapatinib, a tyrosine kinase inhibitor that targets HER2, and siRNA-mediated knockdown of HER2 similarly suppressed cancer cell growth in vitro. …”
Publicado 2021
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2419por Aboudaram, Amélie, Loap, Pierre, Loirat, Delphine, Dhia, Syrine Ben, Cao, Kim, Fourquet, Alain, Kirova, Youlia“…SIMPLE SUMMARY: This retrospective study demonstrates that the combination of locoregional breast RT with dual HER2 blockade by pertuzumab/trastuzumab was very well tolerated, suggesting that RT can be safely administered to patients with HER2-positive breast cancer during dual HER2 blockade. …”
Publicado 2021
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2420por Andersson, Alma, Larsson, Ludvig, Stenbeck, Linnea, Salmén, Fredrik, Ehinger, Anna, Wu, Sunny Z., Al-Eryani, Ghamdan, Roden, Daniel, Swarbrick, Alex, Borg, Åke, Frisén, Jonas, Engblom, Camilla, Lundeberg, Joakim“…To address this, we investigate spatial gene expression in HER2-positive breast tumors using Spatial Transcriptomics technology. …”
Publicado 2021
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