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241“…The epidermal growth factor system has been associated to prognosis in patients with bladder cancer based mainly on the expression of the epidermal growth factor (EGF) receptor 1 (EGFR) and HER2 and their activating ligands. Since limited information exists concerning the expression of other parts of the EGF system, we examined the expression of the receptors HER3 and HER4 and their activating ligands, the heregulins (HRGs), in bladder cancer patients. …”
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242por McMahon, Shannon A, Winch, Peter J, Caruso, Bethany A, Obure, Alfredo F, Ogutu, Emily A, Ochari, Imelda A, Rheingans, Richard DEnlace del recurso
Publicado 2011
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243“…Due to genome duplication events, the zebrafish genome, possesses two gene copies of the mouse Hes7 homologue: her1 and her7. To better understand the functional consequences of this gene duplication, and to determine possible independent roles for these two genes during segmentation, two zebrafish mutants her1(hu2124) and her7(hu2526) were analyzed. …”
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244por Gómez-Martin, Carlos, Garralda, Elena, Echarri, M José, Ballesteros, Anabel, Arcediano, Alberto, Rodríguez-Peralto, José Luis, Hidalgo, Manuel, López-Ríos, Fernando“…HER2 gene amplification approaches might be an optimal HER2/neu testing strategy for the selection of HER2+ GC patients who are candidates to be treated with anti-HER2 therapies.…”
Publicado 2012
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245por Nanni, Patrizia, Gatta, Valentina, Menotti, Laura, De Giovanni, Carla, Ianzano, Marianna, Palladini, Arianna, Grosso, Valentina, Dall'Ora, Massimiliano, Croci, Stefania, Nicoletti, Giordano, Landuzzi, Lorena, Iezzi, Manuela, Campadelli-Fiume, Gabriella, Lollini, Pier-Luigi“…The HER-2-retargeted R-LM249 exclusively infects and kills tumor cells expressing high levels of human HER-2. …”
Publicado 2013
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246por Hamilton, Erika, Blackwell, Kimberly, Hobeika, Amy C, Clay, Timothy M, Broadwater, Gloria, Ren, Xiu-Rong, Chen, Wei, Castro, Henry, Lehmann, Frederic, Spector, Neil, Wei, Junping, Osada, Takuya, Lyerly, H Kim, Morse, Michael AEnlace del recurso
Publicado 2013
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247por Cheng, Huan, Bai, Yalai, Sikov, William, Sinclair, Natalie, Bossuyt, Veerle, Abu-Khalaf, Maysa M, Harris, Lyndsay N, Rimm, David L“…BACKGROUND: Preoperative therapy with chemotherapy and the HER2-targeted monoclonal antibody trastuzumab is valuable for patients with large or locally advanced HER2-positive (HER2+) breast cancers but traditional methods of measuring HER2 expression do not accurately stratify patients for likelihood of response. …”
Publicado 2014
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248por DONG, ZHONGYUN, MELLER, JAROSLAW, SUCCOP, PAUL, WANG, JIANG, WIKENHEISER-BROKAMP, KATHRYN, STARNES, SANDRA, LU, SHAN“…In this study, we further showed that elevated HER/HER2-PI3K-Akt-NF-κB signaling contributes to sPLA2-IIa overexpression in lung cancer cells. sPLA2-IIa in turn phosphorylates and activates HER2 and HER3 in a time- and dose-dependent manner in lung cancer cells. …”
Publicado 2014
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249por Tang, Daoqiang, Liu, Charles YJ, Shen, Danping, Fan, Shuqiong, Su, Xinying, Ye, Peng, Gavine, Paul R, Yin, Xiaolu“…AIM: To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. …”
Publicado 2014
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250por Strasser-Weippl, Kathrin, Horick, Nora, Smith, Ian E, O’Shaughnessy, Joyce, Ejlertsen, Bent, Boyle, Frances, Buzdar, Aman U, Fumoleau, Pierre, Gradishar, William, Martin, Miguel, Moy, Beverly, Piccart-Gebhart, Martine, Pritchard, Kathleen I, Lindquist, Deborah, Rappold, Erica, Finkelstein, Dianne M, Goss, Paul E“…INTRODUCTION: Worldwide, many patients with HER2+ (human epidermal growth factor receptor 2-positive) early breast cancer (BC) do not receive adjuvant trastuzumab. …”
Publicado 2015
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251por Van Cutsem, Eric, Bang, Yung-Jue, Feng-yi, Feng, Xu, Jian M., Lee, Keun-Wook, Jiao, Shun-Chang, Chong, Jorge León, López-Sanchez, Roberto I., Price, Timothy, Gladkov, Oleg, Stoss, Oliver, Hill, Julie, Ng, Vivian, Lehle, Michaela, Thomas, Marlene, Kiermaier, Astrid, Rüschoff, Josef“…The ToGA study provides the largest screening dataset available on HER2 overexpression/amplification in this indication. …”
Publicado 2014
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252“…BACKGROUND AND AIM: Human epidermal growth factor receptor (HER) family plays an important role in gastric cancer (GC), especially HER2. …”
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253por Kim, H, Danishmalik, S N, Hwang, H, Sin, J-I, Oh, J, Cho, Y, Lee, H, Jeong, M, Kim, S-H, Hong, H J“…The antitumor efficacy of the anti-HER2 dMAb was similar to that of four doses of intravenously injected 10 mg kg(−1) Herceptin. …”
Publicado 2016
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254por Ohtsuka, Tomoaki, Sakaguchi, Masakiyo, Yamamoto, Hiromasa, Tomida, Shuta, Takata, Katsuyoshi, Shien, Kazuhiko, Hashida, Shinsuke, Miyata-Takata, Tomoko, Watanabe, Mototsugu, Suzawa, Ken, Soh, Junichi, Youyi, Chen, Sato, Hiroki, Namba, Kei, Torigoe, Hidejiro, Tsukuda, Kazunori, Yoshino, Tadashi, Miyoshi, Shinichiro, Toyooka, Shinichi“…Because HER2 can be a therapeutic target in HER2-driven malignancies, it is important to understand the molecular mechanisms of HER2 activation. …”
Publicado 2016
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255por Shi, Hong-Zhi, Wang, Yu-Ning, Huang, Xiao-Hui, Zhang, Ke-Cheng, Xi, Hong-Qing, Cui, Jian-Xin, Liu, Guo-Xiao, Liang, Wen-Tao, Wei, Bo, Chen, Lin“…AIM: To investigate the association between serum human epidermal growth factor receptor 2 (HER2) extracellular domain (ECD) and tissue HER2 status, and the prognostic value of serum HER2 ECD in patients with gastric cancer. …”
Publicado 2017
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256“…Delta-human epidermal growth factor receptor 2 (HER2) is a splice variant of HER2, which lacks 16 amino acids in the extracellular domain. …”
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257por Lopez-Albaitero, Andres, Xu, Hong, Guo, Hongfen, Wang, Linlin, Wu, Zhihao, Tran, Hoa, Chandarlapaty, Sarat, Scaltriti, Maurizio, Janjigian, Yelena, de Stanchina, Elisa, Cheung, Nai-Kong V.“…Targeted therapies directed at this receptor have achieved responses, although development of resistance is common. We explored a novel HER2/CD3 bispecific antibody (HER2-BsAb) platform that while preserving the anti-proliferative effects of trastuzumab, it recruits and activates non-specific circulating T-cells, promoting T cell tumor infiltration and ablating HER2(+) tumors, even when these are resistant to standard HER2-targeted therapies. …”
Publicado 2017
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258“…INTRODUCTION: Human epidermal growth factor receptor 2 (HER2)-targeted-therapy regimens can lead to prolonged tumour responses in metastatic HER2+ breast cancer. …”
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259por Bon, Giulia, Loria, Rossella, Amoreo, Carla Azzurra, Verdina, Alessandra, Sperduti, Isabella, Mastrofrancesco, Arianna, Soddu, Silvia, Diodoro, Maria Grazia, Mottolese, Marcella, Todaro, Matilde, Stassi, Giorgio, Milella, Michele, De Maria, Ruggero, Falcioni, Rita“…Despite the high efficiency of patritumab in abrogating the HER3-dependent activation of PI3K pathway, the HER2 and EGFR-dependent MAPK pathway is activated as a compensatory mechanism. …”
Publicado 2016
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260por Watson, Spencer S., Dane, Mark, Chin, Koei, Tatarova, Zuzana, Liu, Moqing, Liby, Tiera, Thompson, Wallace, Smith, Rebecca, Nederlof, Michel, Bucher, Elmar, Kilburn, David, Whitman, Matthew, Sudar, Damir, Mills, Gordon B., Heiser, Laura M., Jonas, Oliver, Gray, Joe W., Korkola, James E.“…Extrinsic signals are implicated in breast cancer resistance to HER2-targeted tyrosine kinase inhibitors (TKIs). …”
Publicado 2018
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