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261por Claus, Jeroen, Patel, Gargi, Autore, Flavia, Colomba, Audrey, Weitsman, Gregory, Soliman, Tanya N, Roberts, Selene, Zanetti-Domingues, Laura C, Hirsch, Michael, Collu, Francesca, George, Roger, Ortiz-Zapater, Elena, Barber, Paul R, Vojnovic, Boris, Yarden, Yosef, Martin-Fernandez, Marisa L, Cameron, Angus, Fraternali, Franca, Ng, Tony, Parker, Peter J“…While targeted therapy against HER2 is an effective first-line treatment in HER2(+) breast cancer, acquired resistance remains a clinical challenge. …”
Publicado 2018
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262“…In HER2- cohort we observed increasing levels of MCSF and VEGF trend. …”
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263por Wakatsuki, Takeru, Yamamoto, Noriko, Sano, Takeshi, Chin, Keisho, Kawachi, Hiroshi, Takahari, Daisuke, Ogura, Mariko, Ichimura, Takashi, Nakayama, Izuma, Osumi, Hiroki, Matsushima, Tomohiro, Suenaga, Mitsukuni, Shinozaki, Eiji, Hiki, Naoki, Ishikawa, Yuichi, Yamaguchi, Kensei“…When all tumor cells overexpressed HER2 protein, the tumor was defined as homogeneously HER2 (Homo-HER2)-positive group. …”
Publicado 2018
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264por Griguolo, Gaia, Pascual, Tomás, Dieci, Maria Vittoria, Guarneri, Valentina, Prat, Aleix“…Growing evidence suggests a clear role of the host immune system in HER2+ breast cancer. In addition, HER2+ breast cancer is generally considered more immunogenic than hormone receptor-positive (HR+)/HER2-, and specific molecular HER2+ subgroups (e.g. …”
Publicado 2019
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265“…Here we reveal that HER3, but not EGFR, is also concomitantly downregulated with HER2 after crosslinking. …”
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266por Barber, Paul R, Weitsman, Gregory, Lawler, Katherine, Barrett, James E, Rowley, Mark, Rodriguez-Justo, Manuel, Fisher, David, Gao, Fangfei, Tullis, Iain D C, Deng, Jinhai, Brown, Louise, Kaplan, Richard, Hochhauser, Daniel, Adams, Richard, Maughan, Timothy S., Vojnovic, Borivoj, Coolen, Anthony C C, Ng, Tony“…This study exploits additional information on HER2-HER3 dimerization to achieve patient stratification and reveal previously hidden subgroups of patients who had differing disease progression and treatment response. …”
Publicado 2019
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267por Wang, Chaokun, Chen, Jing, Xu, Xiangyun, Hu, Xiaochen, Kong, Dejiu, Liang, Gaofeng, Wang, Xinshuai“…BACKGROUND: To investigate the pathologic complete response (pCR) rates of dual human epidermal growth factor receptor 2 (HER2) blockade in a neoadjuvant setting for HER2+ breast cancer. …”
Publicado 2020
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268por Cheng, Jackie, Liang, Meina, Carvalho, Miguel F., Tigue, Natalie, Faggioni, Raffaella, Roskos, Lorin K., Vainshtein, Inna“…A bispecific tetravalent anti-HER2 antibody (anti-HER2-Bs), targeting two non-overlapping epitopes on HER2 in domain IV (trastuzumab) and domain II (39S), has been reported to induce rapid internalization and efficient degradation of HER2 receptors. …”
Publicado 2020
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270por Yi, Zongbi, Rong, Guohua, Guan, Yanfang, Li, Jin, Chang, Lianpeng, Li, Hui, Liu, Binliang, Wang, Wenna, Guan, Xiuwen, Ouyang, Quchang, Li, Lixi, Zhai, Jingtong, Li, Chunxiao, Li, Lifeng, Xia, Xuefeng, Yang, Ling, Qian, Haili, Yi, Xin, Xu, Binghe, Ma, Fei“…Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. …”
Publicado 2020
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271“…HER2, a member of the Erythroblastosis Protein B/Human Epidermal Growth Factor Receptor (ErbB/HER) family of receptor tyrosine kinase, is overexpressed in 20~30% of human breast cancers. …”
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272por Liu, Zimin, Shi, Mingpeng, Li, Xiaoxiao, Song, Shanai, Liu, Ning, Du, Haiwei, Ye, Junyi, Li, Haiyan, Zhang, Zhou, Zhang, Lu“…The predictive and prognostic value of HER2 amplification in advanced HER2 inhibitor-treated GA patients has been investigated. …”
Publicado 2021
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273“…We compared features of HER2(+) and HER2 negative (−) cILCs. A total of 29 cases were identified from the clinical database at our institution from 2011-2019; 9 were HER2(+) cILC tumors and 20 were HER2(−) cILC tumors. …”
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274por Leis-Filho, Antonio Fernando, de Faria Lainetti, Patrícia, Emiko Kobayashi, Priscila, Fonseca-Alves, Carlos Eduardo, Laufer-Amorim, Renée“…HER2 is a prognostic and predictive marker widely used in breast cancer. …”
Publicado 2021
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275por Smith, Alison E., Ferraro, Emanuela, Safonov, Anton, Morales, Cristina Bernado, Lahuerta, Enrique J. Arenas, Li, Qing, Kulick, Amanda, Ross, Dara, Solit, David B., de Stanchina, Elisa, Reis-Filho, Jorge, Rosen, Neal, Arribas, Joaquín, Razavi, Pedram, Chandarlapaty, Sarat“…Inhibition of HER2 in HER2-amplified breast cancer has been remarkably successful clinically, as demonstrated by the efficacy of HER-kinase inhibitors and HER2-antibody treatments. …”
Publicado 2021
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276por Falcon, Silvia, Riva, Luis, Flores, Christina, Vera, Delphis, Pinto, Joseph A., Gomez, Henry L.“…The present results of Peruvian patients with HER2 breast cancer treated according to clinical routine demonstrated that dual blockade of HER2 with trastuzumab and pertuzumab in the neoadjuvant setting achieved high rates of pCR even in hormone receptor-positive patients. …”
Publicado 2022
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277por Yang, Liu, Li, Wenfei, Lu, Zhihao, Lu, Ming, Zhou, Jun, Peng, Zhi, Zhang, Xiaotian, Wang, Xicheng, Shen, Lin, Li, Jian“…We divided 63 HER2 positive mCRC into group A and group B according to the use of trastuzumab or not. …”
Publicado 2022
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279por Maddox, Adam L., Brehove, Matthew S., Eliato, Kiarash R., Saftics, Andras, Romano, Eugenia, Press, Michael F., Mortimer, Joanne, Jones, Veronica, Schmolze, Daniel, Seewaldt, Victoria L., Jovanovic-Talisman, Tijana“…SIMPLE SUMMARY: The HER2 status of breast cancers is accurately determined by measuring HER2 protein overexpression and gene amplification. …”
Publicado 2022
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280From Anti-HER-2 to Anti-HER-2-CAR-T Cells: An Evolutionary Immunotherapy Approach for Gastric Cancer“…Targeting the human epidermal growth factor receptor-2 (HER-2) is a viable therapeutic strategy against advanced HER-2 positive GC. …”
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