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2901por Pattanayak, Birlipta, Lameirinhas, Ana, Torres-Ruiz, Sandra, Burgués, Octavio, Rovira, Ana, Martínez, María Teresa, Tapia, Marta, Zazo, Sandra, Albanell, Joan, Rojo, Federico, Bermejo, Begoña, Eroles, Pilar“…Treatment for the HER2+ breast cancer subtype is still unsatisfactory, despite breakthroughs in research. …”
Publicado 2022
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2902por Holthuis, Emily I., Vondeling, Gerard T., Kuiper, Josephina G., Dezentjé, Vincent, Rosenlund, Mats, Overbeek, Jetty A., van Deurzen, Carolien H.M.“…BACKGROUND: With the introduction of investigational human epidermal growth factor receptor 2 (HER2) targeting treatments, thorough understanding of breast cancer with different HER2 expression levels is critical. …”
Publicado 2022
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2903por Shovon, Md. Sakib Hossain, Islam, Md. Jahidul, Nabil, Mohammed Nawshar Ali Khan, Molla, Md. Mohimen, Jony, Akinul Islam, Mridha, M. F.“…To help in this area, a transfer learning-based model called ‘HE-HER2Net’ has been proposed to diagnose multiple stages of HER2 breast cancer (HER2-0, HER2-1+, HER2-2+, HER2-3+) on H&E (hematoxylin & eosin) images from the BCI dataset. …”
Publicado 2022
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2904por Tateyama, Nami, Suzuki, Hiroyuki, Ohishi, Tomokazu, Asano, Teizo, Tanaka, Tomohiro, Mizuno, Takuya, Yoshikawa, Takeo, Kawada, Manabu, Kaneko, Mika K., Kato, Yukinari“…The bispecific E134Bf-H77scFv recognized dog EGFR (dEGFR) and dog HER2 (dHER2)-overexpressed Chinese hamster ovary-K1 cells by flow cytometry. …”
Publicado 2022
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2905por Radhakrishnan, Jagan, Kareem, Abdul, Ratna, Srabanti, Senthilkumar, Sellappan, Biswas, Krishnendu“…[Image: see text] In the present work, we report the synthesis of wurtzite CuGaS(2) and its composite with MoS(2) and explored their efficacy toward two important applications, viz. electrocatalytic hydrogen evolution reaction (HER) and adsorption of Rhodamine B dye. The CuGaS(2) was synthesized via a low-temperature ethylenediamine-mediated solvothermal method. …”
Publicado 2022
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2906“…PURPOSE: Recently, the DESTINY-Breast04 trial revealed that significant benefits in both overall survival (OS) and progression-free survival (PFS) in patients with HER2-low advanced or metastatic breast cancer treated with trastuzumab deruxtecan (T-DXd) compared with chemotherapy. …”
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2907por Rayson, Daniel, Gandhi, Sonal, Joy, Anil A., Brezden-Masley, Christine, Gelmon, Karen A., Sehdev, Sandeep, Cescon, David, Chia, Stephen“…The addition of pertuzumab to neoadjuvant trastuzumab and chemotherapy for women with early-stage, high-risk, HER2+ breast cancer has been observed to lead to higher pathologic complete response rates (pCR), and improved event-free survival compared to trastuzumab and chemotherapy alone. …”
Publicado 2022
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2908“…So far, studies have focused on the role of HER2–HER3 heterodimers, and little is known regarding EGFR–HER2 heterodimers. …”
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2909por Yao, Qian, Hou, Wei, Wu, Kaiyuan, Bai, Yanhua, Long, Mengping, Diao, Xinting, Jia, Ling, Niu, Dongfeng, Li, Xiang“…SIMPLE SUMMARY: HER2 expression is important for target therapy in breast cancer patients, however, accurate evaluation of HER2 expression is challenging for pathologists owing to the ambiguities and subjectivities of manual scoring. …”
Publicado 2022
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2910por Yang, Fan, Li, Jiayi, Zhang, Hong, Zhang, Shuang, Ye, Jingming, Cheng, Yuanjia, Liu, Qian, Xin, Ling, Xiang, Hongyu, Liu, Yinhua, Duan, Xuening, Xu, Ling“…(1) Background: Hormone receptor positive breast cancer is a subtype of breast cancer with relatively good prognosis, but luminal B (HER–2 negative) breast cancer has a higher risk of recurrence and metastasis. …”
Publicado 2022
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2911“…OBJECTIVE: Our study evaluated the renal safety of abemaciclib plus endocrine therapy (ET) with bisphosphonate as a treatment option for hormone receptor positive, human epidermal growth factor receptor 2 (HER‐2) negative (HR+/HER2−) advanced breast cancer (ABC), especially with bone metastasis. …”
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2912por Wu, Zehua, Cheng, Yi, Wang, Huaiming, Liu, Dian, Qi, Xiaoxing, Wang, Chao, Zhang, Yuanzhe, Zhang, Yuting, Cai, Runkai, Huo, Hong, Zhang, Jianwei, Cai, Yue, Li, Weiwei, Hu, Huabin, Deng, Yanhong“…SIMPLE SUMMARY: In recent years, the antibody-drug conjugate (ADC) of Human Epidermal Growth Factor Receptor 2 (HER2) has been found to play an important role in some HER2-negative cancers as in it did in HER2-positive patients. …”
Publicado 2023
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2913“…INTRODUCTION: Nanobubble is an innovative ultrasound contrast agent that triggers the development of targeted imaging of HER2-positive breast cancer by combining with HER2 affibody and IR783. …”
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2914por Elton, SarahEnlace del recurso
Publicado 2023
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2915por Oguchi, Kei, Araki, Hikari, Tsuji, Shingo, Nakamura, Masayuki, Miura, Akihiro, Funabashi, Kaoru, Osada, Akiko, Tanaka, Sakiho, Suzuki, Takamasa, Kobayashi, Susumu S., Mizuarai, Shinji“…Genetic alterations in human epidermal growth factor receptor type 2 (HER2)/epidermal growth factor receptor (EGFR) are commonly associated with breast and lung cancers and glioblastomas. …”
Publicado 2022
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2916por Hayat, Ateequllah, Carter, Edward P., King, Hamish W., Ors, Aysegul, Doe, Aaron, Teijeiro, Saul A., Charrot, Sarah, Godinho, Susana, Cutillas, Pedro, Mohammed, Hisham, Grose, Richard P., Ficz, Gabriella“…Overexpression of the HER2 protein in breast cancer patients is a predictor of poor prognosis and resistance to therapies. …”
Publicado 2023
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2917“…RESULTS: SDS-PAGE analysis confirmed the successful co-expression of anti-HER2-scFv and DnaK/DnaJ/GrpE chaperones. Co-expression with chaperones and low-temperature cultivation synergistically improved the soluble expression of anti-HER2 scFv. …”
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2918por Rasha, Fahmida, Boligala, Geetha Priya, Yang, Mingxiao V., Martinez-Marin, Dalia, Castro-Piedras, Isabel, Furr, Kathryn, Snitman, Annie, Khan, Sonia Y., Brandi, Luis, Castro, Maribel, Khan, Hafiz, Jahan, Nusrat, Almodovar, Sharilyn, Melkus, Michael W., Pruitt, Kevin, Layeequr Rahman, Rakhshanda“…This study aimed to uncover the novel interaction between DVL2 and HER2-positive (HER2+) breast cancer (BC) in regulating tumor immunity and disease progression. …”
Publicado 2023
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2919por Vathiotis, Ioannis A., Bafaloukos, Dimitrios, Syrigos, Konstantinos N., Samonis, George“…Despite the impressive results, several matters need to be addressed, including the clinical activity of T-DXd in patients with disease in the central nervous system as well as the role of T-DXd in the context of HER2 overexpression. Additionally, data regarding novel agents used to target HER2 continue to accumulate. …”
Publicado 2023
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2920por Tang, Yuyao, Shen, Guoshuang, Xin, Yuanfang, Li, Zhoujuan, Zheng, Yonghui, Wang, Miaozhou, Liu, Zhen, Zhao, Yi, Zhao, Fuxing, Ren, Dengfeng, Zhao, Jiuda“…However, the role of HER2-low expression in the prognosis of BC remains controversial. …”
Publicado 2023
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