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3081“…BACKGROUND: Previous studies have been inconsistent with respect to the reported associations between human epidermal growth factor receptor (HER-2/neu) overexpression in colorectal cancer. …”
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3082“…Here, we apply SNAP display for the affinity maturation of a designed ankyrin repeat proteins (DARPin) that binds to the extracellular domain of HER2 previously isolated by ribosome display. After four SNAP display selection cycles, proteins that bound specifically to HER2 in vitro, with dissociation constants in the low- to sub-nanomolar range, were isolated. …”
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3083por Feilchenfeldt, J, Varga, Z, Siano, M, Grabsch, H I, Held, U, Schuknecht, B, Trip, A, Hamaguchi, T, Gut, P, Balague, O, Khanfir, K, Diebold, J, Jochum, W, Shoji, H, Kushima, R, Wagner, D, Shimada, Y, Cats, A, Knuth, A, Moch, H, Aebi, S, Hofer, S“…The role of the human epidermal growth factor receptor 2 (HER2) in patients with these cancers and CNS involvement is presently unknown. …”
Publicado 2015
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3084“…Characterized genes defining subgroups within the ER–/PgR+/HER2– phenotype were determined and further validated. …”
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3085por Villa-Moruzzi, Emma“…Background: HER2 activation in tumours supports multiple signalling pathways, including those regulating invasion and metastasis. …”
Publicado 2011
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3086“…An insight into the role of DARPin-miniSOG in HER2 internalization could contribute to the treatment of HER2-positive cancer using this phototoxic protein.…”
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3087por Walch, Axel, Bink, Karin, Gais, Peter, Stangl, Stefan, Hutzler, Peter, Aubele, Michaela, Mueller, James, Höfler, Heinz, Werner, Martin“…Amplifiction of the Her-2/neu gene is accompanied by overexpression of its cell surface receptor product, c‐erbB‐2 protein. …”
Publicado 2000
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3088por Yang, Rachel L., Mick, Rosemarie, Lee, Kathreen, Graves, Holly L., Nathanson, Katherine L., Domchek, Susan M., Kelz, Rachel R., Zhang, Paul J., Czerniecki, Brian J.“…Invasive breast cancer (IBC) and DCIS were stained for ER, PR, HER1, HER2, and HER3, and C-MET. DCIS prevalence was evaluated. …”
Publicado 2015
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3089por De Falco, Mariarosaria, Catalano, Federico, Rossi, Mosè, Ciaramella, Maria, De Felice, Mariarita“…The nuclease NurA and the ATPase HerA are present in all known thermophilic archaea and cooperate with the highly conserved MRE11/RAD50 proteins to facilitate efficient DNA double-strand break end processing during homologous recombinational repair. …”
Publicado 2015
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3090por Rossi, L, Laas, E, Mallon, P, Vincent-Salomon, A, Guinebretiere, J-M, Lerebours, F, Rouzier, R, Pierga, J-Y, Reyal, F“…The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2− tumours having discrepant MI and Ki67. METHODS: We included a cohort of breast cancer patients initially treated by surgery between 2001 and 2005 in the Institut Curie. …”
Publicado 2015
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3091por Jenkins, Robert P., Hanisch, Anja, Soza-Ried, Cristian, Sahai, Erik, Lewis, Julian“…Using in situ hybridisation to visualise sites of active her1 transcription, we measure an average delay of approximately three minutes between the times of activation of the two her1 alleles in a cell. …”
Publicado 2015
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3092por Bowers, Laura W., Wiese, Megan, Brenner, Andrew J., Rossi, Emily L., Tekmal, Rajeshwar R., Hursting, Stephen D., deGraffenried, Linda A.“…Expression of Bcl-2 and cyclin D1, two genes negatively regulated by ERβ, was elevated in SKBR3 cells following exposure to OB versus N sera, but this difference was eliminated when the ERβ gene was silenced with siRNA. Herceptin, a HER2 antagonist, and siRNA to HER2 were used to evaluate the role of HER2 in sera-induced ERβ modulation. …”
Publicado 2015
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3093por Triulzi, Tiziana, De Cecco, Loris, Sandri, Marco, Prat, Aleix, Giussani, Marta, Paolini, Biagio, Carcangiu, Marialuisa L., Canevari, Silvana, Bottini, Alberto, Balsari, Andrea, Menard, Sylvie, Generali, Daniele, Campiglio, Manuela, Di Cosimo, Serena, Tagliabue, Elda“…Application of the TRAR model to 24 HER2+ core biopsies from patients treated with neo-adjuvant trastuzumab indicated that it is predictive of trastuzumab response. …”
Publicado 2015
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3094por Feilchenfeldt, J, Varga, Z, Siano, M, Grabsch, H I, Held, U, Schuknecht, B, Trip, A, Hamaguchi, T, Gut, P, Balague, O, Khanfir, K, Diebold, J, Jochum, W, Shoji, H, Kushima, R, Wagner, D, Shimada, Y, Cats, A, Knuth, A, Moch, H, Aebi, S, Hofer, SEnlace del recurso
Publicado 2015
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3095por Gschwantler-Kaulich, Daphne, Grunt, Thomas W., Muhr, Daniela, Wagner, Renate, Kölbl, Heinz, Singer, Christian F.“…BACKGROUND: HER-targeted tyrosine kinase inhibitors (TKIs) have demonstrated pro-apoptotic and antiproliferative effects in vitro and in vivo. …”
Publicado 2016
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3096“…Furthermore, depletion or inhibition of Hhat reduced proliferation of HER2 amplified as well as tamoxifen resistant cells. …”
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3097por Sokolova, E. A., Stremovskiy, O. A., Zdobnova, T. A., Balalaeva, I. V., Deyev, S. M.“…High affinity of the immunotoxin for the HER2 tumor marker, its selective cytotoxicity against HER2-overexpressing cells, and its storage stability were demonstrated. …”
Publicado 2015
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3098“…At final follow-up 12 months after surgery her Lysholm score had improved from 79 to 95 on her left side and from 74 to 78 on her right. …”
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3099por OKITA, RIKI, SHIMIZU, KATSUHIKO, NOJIMA, YUJI, YUKAWA, TAKURO, MAEDA, AI, SAISHO, SHINSUKE, NAKATA, MASAO“…EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). …”
Publicado 2015
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3100por Lin, Peggy L., Hao, Yanni, Xie, Jipan, Li, Nanxin, Zhong, Yichen, Zhou, Zhou, Signorovitch, James E., Wu, Eric Q.“…Sequential endocrine therapy (ET) is recommended for postmenopausal women with hormone receptor‐positive (HR+)/human epidermal growth factor receptor 2‐negative (HER2−) metastatic breast cancer (mBC) and without visceral symptoms. …”
Publicado 2015
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