Mostrando 3,081 - 3,100 Resultados de 58,773 Para Buscar '"Her"', tiempo de consulta: 0.81s Limitar resultados
  1. 3081
    por Wu, Sheng-wen, Ma, Cong-chao, Li, Wen-hui
    Publicado 2015
    “…BACKGROUND: Previous studies have been inconsistent with respect to the reported associations between human epidermal growth factor receptor (HER-2/neu) overexpression in colorectal cancer. …”
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  2. 3082
    “…Here, we apply SNAP display for the affinity maturation of a designed ankyrin repeat proteins (DARPin) that binds to the extracellular domain of HER2 previously isolated by ribosome display. After four SNAP display selection cycles, proteins that bound specifically to HER2 in vitro, with dissociation constants in the low- to sub-nanomolar range, were isolated. …”
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  3. 3083
  4. 3084
    “…Characterized genes defining subgroups within the ER–/PgR+/HER2– phenotype were determined and further validated. …”
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  5. 3085
    por Villa-Moruzzi, Emma
    Publicado 2011
    “…Background: HER2 activation in tumours supports multiple signalling pathways, including those regulating invasion and metastasis. …”
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  6. 3086
    “…An insight into the role of DARPin-miniSOG in HER2 internalization could contribute to the treatment of HER2-positive cancer using this phototoxic protein.…”
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  7. 3087
    “…Amplifiction of the Her-2/neu gene is accompanied by overexpression of its cell surface receptor product, c‐erbB‐2 protein. …”
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  8. 3088
  9. 3089
    “…The nuclease NurA and the ATPase HerA are present in all known thermophilic archaea and cooperate with the highly conserved MRE11/RAD50 proteins to facilitate efficient DNA double-strand break end processing during homologous recombinational repair. …”
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  10. 3090
    “…The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2− tumours having discrepant MI and Ki67. METHODS: We included a cohort of breast cancer patients initially treated by surgery between 2001 and 2005 in the Institut Curie. …”
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  11. 3091
    “…Using in situ hybridisation to visualise sites of active her1 transcription, we measure an average delay of approximately three minutes between the times of activation of the two her1 alleles in a cell. …”
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  12. 3092
    “…Expression of Bcl-2 and cyclin D1, two genes negatively regulated by ERβ, was elevated in SKBR3 cells following exposure to OB versus N sera, but this difference was eliminated when the ERβ gene was silenced with siRNA. Herceptin, a HER2 antagonist, and siRNA to HER2 were used to evaluate the role of HER2 in sera-induced ERβ modulation. …”
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  13. 3093
  14. 3094
  15. 3095
    “…BACKGROUND: HER-targeted tyrosine kinase inhibitors (TKIs) have demonstrated pro-apoptotic and antiproliferative effects in vitro and in vivo. …”
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  16. 3096
    por Matevossian, Armine, Resh, Marilyn D
    Publicado 2015
    “…Furthermore, depletion or inhibition of Hhat reduced proliferation of HER2 amplified as well as tamoxifen resistant cells. …”
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  17. 3097
    “…High affinity of the immunotoxin for the HER2 tumor marker, its selective cytotoxicity against HER2-overexpressing cells, and its storage stability were demonstrated. …”
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  18. 3098
    “…At final follow-up 12 months after surgery her Lysholm score had improved from 79 to 95 on her left side and from 74 to 78 on her right. …”
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  19. 3099
    “…EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). …”
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  20. 3100
    “…Sequential endocrine therapy (ET) is recommended for postmenopausal women with hormone receptor‐positive (HR+)/human epidermal growth factor receptor 2‐negative (HER2−) metastatic breast cancer (mBC) and without visceral symptoms. …”
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