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3221por Ninio-Many, Lihi, Hikri, Elad, Burg-Golani, Tamar, Stemmer, Salomon M., Shalgi, Ruth, Ben-Aharon, Irit“…The EGFR/HER2 signaling network is an effective therapeutic target for HER2-positive cancers, which are known for their aggressive biological course. …”
Publicado 2020
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3222“…Cell experiments showed that up-regulation of IL-1β downregulates claudin18 to promote lung barrier function damage by regulating the IL-1β-HER2/HER3 axis, further promoting the development of ARDS. …”
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3223por Anwar, Sumadi Lukman, Dwianingsih, Ery Kus, Avanti, Widya Surya, Choridah, Lina, Suwardjo, Aryandono, Teguh“…Colloid breast carcinoma generally expresses estrogen and progesterone receptors but negative for Her-2. Recommended surgery and adjuvant treatment of colloid breast carcinoma is not well-established. …”
Publicado 2020
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3224“…BACKGROUND: The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. …”
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3225por Rinne, Sara S., Dahlsson Leitao, Charles, Saleh-nihad, Zahra, Mitran, Bogdan, Tolmachev, Vladimir, Ståhl, Stefan, Löfblom, John, Orlova, Anna“…HER3-binding affibody molecules are a promising format for visualization of HER3 expression. …”
Publicado 2020
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3226por Bryant, Kelsey B.Enlace del recurso
Publicado 2020
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3227por Li, Hui, Zhang, Mingming, Wei, Yanli, Haider, Farhan, Lin, Yitong, Guan, Wen, Liu, Yanbin, Zhang, Shaoyang, Yuan, Ronghua, Yang, Xia, Yang, Shulan, Wang, Haihe“…BACKGROUND: HER2-positive breast cancer is usually associated to the more aggressive progression and the worse prognosis, but the mechanism underlying the innate resistance to HER2-targeted therapy remains elusive. …”
Publicado 2020
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3228por Gomes, Inês, de Almeida, Bernardo P., Dâmaso, Sara, Mansinho, André, Correia, Inês, Henriques, Sara, Cruz-Duarte, Raquel, Vilhais, Guilherme, Félix, Pedro, Alves, Patrícia, Corredeira, Patrícia, Barbosa-Morais, Nuno L., Costa, Luis, Casimiro, Sandra“…These results suggest that ER+HER2- RANK-positive cells may constitute an important reservoir of slow cycling, therapy-resistance cancer cells; and that RANK pathway activation is deleterious in all ER+HER2- breast cancer cells, independently of RANK levels.…”
Publicado 2020
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3229por Mawaribuchi, Shuuji, Haramoto, Yoshikazu, Tateno, Hiroaki, Onuma, Yasuko, Aiki, Yasuhiko, Ito, Yuzuru“…We conclude that rBC2LCN may have potential as a detection probe and a drug delivery vehicle to identify and treat early‐stage HER2‐positive breast carcinoma.…”
Publicado 2020
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3230por Xu, Yuping, Wang, Lizhen, Pan, Donghui, Yan, Junjie, Wang, Xinyu, Yang, Runlin, Li, Mingzhu, Liu, Yu, Yang, Min“…BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is an essential biomarker for tumor treatment. …”
Publicado 2020
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3231por González-Alonso, Paula, Zazo, Sandra, Martín-Aparicio, Ester, Luque, Melani, Chamizo, Cristina, Sanz-Álvarez, Marta, Minguez, Pablo, Gómez-López, Gonzalo, Cristóbal, Ion, Caramés, Cristina, García-Foncillas, Jesús, Eroles, Pilar, Lluch, Ana, Arpí, Oriol, Rovira, Ana, Albanell, Joan, Piersma, Sander R., Jimenez, Connie R., Madoz-Gúrpide, Juan, Rojo, Federico“…Trastuzumab is the first-line targeted therapeutic drug for HER2-positive breast cancer, leading to improved overall survival. …”
Publicado 2020
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3232por Irie, Hiroki, Kawabata, Rumi, Fujioka, Yayoi, Nakagawa, Fumio, Itadani, Hiraku, Nagase, Hideki, Ito, Kimihiro, Uchida, Junji, Ohkubo, Shuichi, Matsuo, Kenichi“…HER2‐targeting antibodies (trastuzumab, pertuzumab) and a HER2‐directed antibody‐drug conjugate (trastuzumab emtansine: T‐DM1) are used for the treatment of HER2‐overexpressing breast cancer. …”
Publicado 2020
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3233por Hegde, Meenakshi, Joseph, Sujith K., Pashankar, Farzana, DeRenzo, Christopher, Sanber, Khaled, Navai, Shoba, Byrd, Tiara T., Hicks, John, Xu, Mina L., Gerken, Claudia, Kalra, Mamta, Robertson, Catherine, Zhang, Huimin, Shree, Ankita, Mehta, Birju, Dakhova, Olga, Salsman, Vita S., Grilley, Bambi, Gee, Adrian, Dotti, Gianpietro, Heslop, Helen E., Brenner, Malcolm K., Wels, Winfried S., Gottschalk, Stephen, Ahmed, Nabil“…Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to autologous HER2 CAR T cells. Three cycles of HER2 CAR T cells given after lymphodepleting chemotherapy induces remission which is consolidated with four more CAR T-cell infusions without lymphodepletion. …”
Publicado 2020
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3234por Zervantonakis, Ioannis K., Poskus, Matthew D., Scott, Alexis L., Selfors, Laura M., Lin, Jia-Ren, Dillon, Deborah A., Pathania, Shailja, Sorger, Peter K., Mills, Gordon B., Brugge, Joan S.“…Despite the implementation of multiple HER2-targeted therapies, patients with advanced HER2(+) breast cancer ultimately develop drug resistance. …”
Publicado 2020
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3235por Lutrino, Eufemia S., Orlando, Laura, Febbraro, Antonio, Giampaglia, Marianna, Zamagni, Claudio, Schiavone, Paola, Scavelli, Claudio, Dima, Gianluca, Fedele, Palma, Giordano, Guido, Bilancia, Domenico, Quaranta, Anna Maria, Rubino, Daniela, Filippelli, Gianfranco, Fontanella, Caterina, Caliolo, Chiara, Marino, Antonella, Calvani, Nicola, Ferrara, Pasqualinda, Cinieri, Saverio“…BACKGROUND: Chemotherapy plus targeted therapy is the established treatment for human epidermal growth factor receptor 2 (HER2)–overexpressing breast cancer (BC). Limited data regarding the safety and activity of the combination of eribulin and trastuzumab (E/T) in pretreated HER2-positive advanced BC (ABC) are available. …”
Publicado 2019
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3236“…INTRO: One in three women with HER2-positive breast cancer will develop brain metastases, or intracranial metastatic disease (IMD). …”
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3237por Malani, Rachna, Fleisher, Martin, Kumthekar, Priya, Lin, Xuling, Omuro, Antonio, Groves, Morris D., Lin, Nancy U., Melisko, Michelle, Lassman, Andrew B., Jeyapalan, Suriya, Seidman, Andrew, Skakodub, Anna, Boire, Adrienne, DeAngelis, Lisa M., Rosenblum, Marc, Raizer, Jeffrey, Pentsova, Elena“…Median CSF CTC was 22 CTCs (range 0–200 +) per 3 ml. HER2/neu expression analysis of CTCs was performed in 8 patients; 75% had confirmed expression of HER2/neu positivity in CSF and HER2/neu expression was absent in 25%. …”
Publicado 2020
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3238por Hussein, Israa A, Ahmed, Shatha Th, Hameedi, Ameer D, Naji, Rana Z, Alharbawi, Layth, Alkhaytt, Muzahm, Pity, Intisar S“…High number of cases with negative BRCA1 expression showed negative ER, PR and Her2/neu expression.…”
Publicado 2020
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3239por Yang, Shu, Chen, Binni, Zhang, Baogen, Li, Caiping, Qiu, Yuena, Yang, Hanhui, Huang, Zhongxin“…Furthermore, an increased apoptotic rate was detected following overexpression of miR-204-5p, along with increased expression levels of Bax and decreased expression levels of Bcl-2. HER-2 was a direct target of miR-204-5p, and inhibition of HER-2 acted as a tumor suppressor by inhibiting cell proliferation, migration and invasion, and promoting cell apoptosis, which was reversed by the inhibition of miR-204-5p expression. …”
Publicado 2020
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3240por Duffy, Ciara, Sorolla, Anabel, Wang, Edina, Golden, Emily, Woodward, Eleanor, Davern, Kathleen, Ho, Diwei, Johnstone, Elizabeth, Pfleger, Kevin, Redfern, Andrew, Iyer, K. Swaminathan, Baer, Boris, Blancafort, Pilar“…Here, we demonstrate that honeybee venom and its major component melittin potently induce cell death, particularly in the aggressive triple-negative and HER2-enriched breast cancer subtypes. Honeybee venom and melittin suppress the activation of EGFR and HER2 by interfering with the phosphorylation of these receptors in the plasma membrane of breast carcinoma cells. …”
Publicado 2020
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