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3401
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3402“…The overexpression of the human epidermal growth factor 2 (HER2/neu) oncogene is predictive of adverse breast cancer prognosis. …”
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3403“…Different from the poor graphene, R-graphyne, which is completely composed of anti-aromatic structural units, can exhibit certain HER catalytic activity. In addition, doping the TM atoms in Group VIIIB can be considered an effective strategy to enhance the HER catalytic activity of R-graphyne. …”
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3404“…Once Maria Sibylla published her book Metamorphosis Insectorum Surinamensium by her own, without male co-authors, and also this book is one of the only to have text and illustrations altogether and there are reports indicating information on useful plants in this work, she and her book were chosen as subject of this research. …”
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3405por Liu, Dan, Kou, Furong, Gong, Jifang, Wang, Zhiqiang, Zhang, Xiaotian, Li, Jian, Li, Yan, Li, Jie, Zhou, Jun, Lu, Ming, Wang, Xicheng, Lu, Zhihao, Cao, Yanshuo, Zou, Jianjun, Zhu, Xiaoyu, Xu, Ruihua, Shen, Lin“…AIM: Pyrotinib (an irreversible pan‐ErbB small‐molecular tyrosine kinase inhibitor) was approved in human epidermal growth factor receptor 2 (HER2)‐positive breast cancer and showed great antitumor activity in preclinical studies of gastric cancer (GC). …”
Publicado 2023
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3406por Chen, Xuelian, Bai, Xue, Xie, Xiaofeng, Huang, Jiayi, Chen, Liping, Song, Lin, Lan, Xiaofeng, Zhang, Qiuyi, Guo, Jinfeng, Du, Caiwen“…BACKGROUND: More than half of the metastatic breast cancer patients with brain metastases (BCBM) are HER-2 negative, and the prognosis of HER2-negative BCBM is dismal. …”
Publicado 2023
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3407por Mao, Shiqi, Yang, Shuo, Liu, Xinyu, Li, Xingya, Wang, Qiming, Zhang, Yiping, Chen, Jianhua, Wang, Yan, Gao, Guanghui, Wu, Fengying, Jiang, Tao, Zhang, Jiao, Yang, Ying, Lin, Xiang, Zhu, Xiaoyu, Zhou, Caicun, Ren, Shengxiang“…BACKGROUND: Non-small cell lung cancer (NSCLC) with HER2 mutation has entered into the era of targeted therapy. …”
Publicado 2023
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3408por Salem, Mostafa E., Mahrous, Esraa M., Ragab, Eman A., Nafie, Mohamed S., Dawood, Kamal M.“…Compounds 18c exhibited promising EGFR and HER-2 inhibitory activities with IC(50) = 4.98 and 9.85 nM, respectively, compared to Lapatinib (IC(50) = 6.1 and 17.2 nM). …”
Publicado 2023
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3409“…Pyrotinib is a novel irreversible tyrosine kinase inhibitor targeting the human epidermal growth factor receptor (HER), whose efficacy in treating metastatic HER2-positive (HER2(+)) breast cancer has been confirmed. …”
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3410por Abu Al Karsaneh, Ola, Al Anber, Arwa, ALQudah, Mohammad, Al-Mustafa, Sahar, AlMa’aitah, Hussien, Sughayer, Maher“…BACKGROUND: Human epidermal growth factor receptor 2 (HER2), a promising therapeutic target, can be mutated, amplified, or overexpressed in different malignancies, including non-small cell lung cancer (NSCLC). …”
Publicado 2023
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3411“…CONCLUSION: Our study provides important evidence that BB use potentially has a negative effect on patients with HER2-positive advanced breast cancer. Nevertheless, despite the study’s results, cardiovascular disease (CVD) should be appropriately treated in patients with HER2-positive advanced breast cancer. …”
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3412por He, Peng, Xu, Shenglin, Miao, Zhaohua, Que, Yukang, Chen, Yu, Li, Sheng, Ma, Qiming, Yang, Rui, Wei, Wei, Zha, Zhengbao, Hu, Yong“…In this study, we designed target-modified arsenene nanosheets loaded with cisplatin (Her2-ANs@CDDP), which are capable of selective uptake by tumor cells. …”
Publicado 2023
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3413por Pons, Laura, Hernández, Laura, Urbizu, Aintzane, Osorio, Paula, Rodríguez-Martínez, Paula, Castella, Eva, Muñoz, Ana, Sanz, Carolina, Arnaldo, Laura, Felip, Eudald, Quiroga, Vanesa, Tapia, Gustavo, Margelí, Mireia, Fernandez, Pedro Luis“…SIMPLE SUMMARY: HER2+ and triple negative breast cancers are widely known for their aggressiveness, frequent resistance to treatment and poor prognosis. …”
Publicado 2023
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3414por Wang, Fengge, Liu, Honghui, Xu, Yanyan, Liang, Zhiwen, Wu, Zhisheng, Liu, Yang, Zhang, Baijun“…Human epidermal growth factor receptor-3 (HER-3) plays a key role in the growth and metastasis of cancer cells. …”
Publicado 2023
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3415por Shi, Yunjing, Qiu, Zeping, Yu, Jing, Li, Zhuojin, Hua, Sha, Chen, Yanjia, Chen, Xiaosong, Shen, Kunwei, Jin, Wei“…This study investigated the impact of insulin resistance on cardiac remodeling in patients with human epidermal growth factor receptor 2 (HER2)-positive BC during and after trastuzumab therapy in real-world clinical practice. …”
Publicado 2023
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3416por Zhang, Jian, McAndrew, Nicholas P., Wang, Xiaojia, Du, Yiqun, DiCarlo, Brian, Wang, Mei, Chen, Kan, Yu, Wenlei, Hu, Xichun“…BACKGROUND: Patients with HER2-positive metastatic breast cancer (MBC) are at high risk of developing central nervous system (CNS) metastases. …”
Publicado 2023
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3417por Batista, Marta Vaz, Perez-Gracia, José, Eiriz, Inês, Gion, Maria, Llombart, Antonio, Braga, Sofia, Cortés, JavierEnlace del recurso
Publicado 2023
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3418por Yu, Wayne, Ramprasad, Mysore P., Pal, Manoj, Chen, Chris, Paruchuri, Shashi, Skidmore, Lillian, Knudsen, Nick, Allen, Molly, Buechler, Ying“…ARX788 is an anti-HER2 antibody drug conjugate (ADC) developed using Ambrx proprietary Engineered Precision Biologics technology. …”
Publicado 2023
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3419
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3420“…Metastatic human epidermal growth factor receptor 2 (HER2) positive breast cancer has a poor prognosis and few effective targeted therapies. …”
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