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3521por van der Logt, Elise M. J., Kuperus, Deborah A. J., van Setten, Jan W., van den Heuvel, Marius C., Boers, James. E., Schuuring, Ed, Kibbelaar, Robby E.“…HER2 assessment is routinely used to select patients with invasive breast cancer that might benefit from HER2-targeted therapy. …”
Publicado 2015
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3523“…We suggested that GCDFP-15, AR, and Her-2 should be tested as biomarkers for ductal adenocarcinoma of lacrimal gland to confirm diagnosis, guide therapy, and further predict prognosis.…”
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3524por Laas, E, Mallon, P, Delomenie, M, Gardeux, V, Pierga, J-Y, Cottu, P, Lerebours, F, Stevens, D, Rouzier, R, Reyal, F“…METHODS: We used a large data set (n=965) of women with hormone receptor-positive and HER2-negative early breast cancer from the public data set of the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study. …”
Publicado 2015
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3525por Leung, Wing-yin, Roxanis, Ioannis, Sheldon, Helen, Buffa, Francesca M., Li, Ji-Liang, Harris, Adrian L., Kong, Anthony“…Acquired resistance to lapatinib, an inhibitor of EGFR and HER2 kinases, is common. We found that reactivation of EGFR, HER2 and HER3 occurred within 24 hours of lapatinib treatment after their initial dephosphorylation. …”
Publicado 2015
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3526por Bull-Hansen, Bente, Berstad, Maria B., Berg, Kristian, Cao, Yu, Skarpen, Ellen, Fremstedal, Ane Sofie, Rosenblum, Michael G., Peng, Qian, Weyergang, Anette“…HER2-targeted therapy has been shown to have limited efficacy in ovarian cancer despite frequent overexpression of this receptor. …”
Publicado 2015
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3527por Chung, Yuan-Chiang, Kuo, Jang-Fang, Wei, Wan-Chen, Chang, King-Jen, Chao, Wei-Ting“…FDA to treat human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer. Despite its effectiveness in most patients, some are initially resistant or develop resistance. …”
Publicado 2015
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3528por Rossi, Elisa, Grisanti, Salvatore, Villanacci, Vincenzo, Casa, Domenico Della, Cengia, Paolo, Missale, Guido, Minelli, Luigi, Buglione, Michela, Cestari, Renzo, Bassotti, Gabrio“…Our aim was to evaluate the role of HER2 overexpression/amplification in predicting the conversion from precursor lesions to ADC. …”
Publicado 2009
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3529por Lal, Sangeet, Kersch, Cymon, Beeson, Kathleen A., Wu, Y. Jeffrey, Muldoon, Leslie L., Neuwelt, Edward A.“…CONCLUSIONS: αv-integrin interacts with HER2 in breast cancer cells and may regulate HER2 localization. …”
Publicado 2015
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3530por Sonnenblick, Amir, Brohée, Sylvain, Fumagalli, Debora, Vincent, Delphine, Venet, David, Ignatiadis, Michail, Salgado, Roberto, Van den Eynden, Gert, Rothé, Françoise, Desmedt, Christine, Neven, Patrick, Loibl, Sibylle, Denkert, Carsten, Joensuu, Heikki, Loi, Sherene, Sirtaine, Nicolas, Kellokumpu-Lehtinen, Pirkko-Liisa, Piccart, Martine, Sotiriou, Christos“…BACKGROUND: The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. …”
Publicado 2015
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3531por Mirzaie, Sako, Monajjemi, Majid, Hakhamaneshi, Mohammad Saeed, Fathi, Fardin, Jamalan, Mostafa“…A series of new quinazoline derivatives has been recently reported as potent multi-acting histone deacetylase (HDAC), epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2) inhibitors. HER2 is one of the major targets for the treatment of breast cancer and other carcinomas. …”
Publicado 2013
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3532por Chen, Hao, Ye, Qingqing, Lv, Jing, Ye, Peng, Sun, Yun, Fan, Shuqiong, Su, Xinying, Gavine, Paul, Yin, Xiaolu“…The aim of the study was to investigate trastuzumab anti-tumor efficacy and its correlation with HER-2 status in primary xenograft models derived from Chinese patients with gastric adenocarcinoma. …”
Publicado 2015
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3533por Kerber, Kate J, Mathai, Matthews, Lewis, Gwyneth, Flenady, Vicki, Erwich, Jan Jaap HM, Segun, Tunde, Aliganyira, Patrick, Abdelmegeid, Ali, Allanson, Emma, Roos, Nathalie, Rhoda, Natasha, Lawn, Joy E, Pattinson, RobertEnlace del recurso
Publicado 2015
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3534por Bailur, Jithendra Kini, Derhovanessian, Evelyna, Gueckel, Brigitte, Pawelec, Graham“…In contrast, there was a survival benefit of possessing Her-2-reactive CD8+ T-cells, but this was abrogated in patients if they also had CD4+ Her-2-responsive T-cells that producedIL-5 and/or IL-17 (p = 0.01). …”
Publicado 2015
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3535por Moelans, Cathy B., de Weger, Roel A., van Blokland, Marja T.M., Ezendam, Chantal, Elshof, Sabrina, Tilanus, Marcel G. J., van Diest, Paul J.“…Background: Assessment of HER-2/neu status in invasive breast cancer is crucial to establish eligibility for trastuzumab and taxane based chemotherapy. …”
Publicado 2009
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3536por Grabsch, Heike, Sivakumar, Shivan, Gray, Sally, Gabbert, Helmut E., Müller, Wolfram“…Methods: HER2 expression was investigated by immunohistochemistry in 418 GC from Germany and 506 GC from England. …”
Publicado 2010
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3537por Laboissiere, Renato Santos, Buzelin, Marcelo Araújo, Balabram, Débora, De Brot, Marina, Nunes, Cristiana Buzelin, Rocha, Rafael Malagoli, Cabral, Mônica Maria Demas Álvares, Gobbi, Helenice“…Trastuzumab was recently approved for metastatic or locally advanced carcinomas arising in the stomach or in the gastroesophageal junction in patients with HER2-positive tumors. However, data on the frequency of HER2-positive cases among Brazilian patients are limited. …”
Publicado 2015
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3538por Ahmed, Nabil, Brawley, Vita, Hegde, Meenakshi, Bielamowicz, Kevin, Wakefield, Amanda, Ghazi, Alexia, Ashoori, Aidin, Diouf, Oumar, Gerken, Claudia, Landi, Daniel, Kalra, Mamta, Yi, Zhongzhen, Rooney, Cliona, Dotti, Gianpietro, Gee, Adrian, Heslop, Helen, Gottschalk, Stephen, Powell, Suzanne, Grossman, Robert, Wels, Winfried, Kew, Yzonne, Baskin, David, Zhang, Jonathan, New, Pamela, Hicks, JohnEnlace del recurso
Publicado 2015
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3539por Wu, Shou-Cheng, Chen, Yu-Jen, Wang, Hsiang-Ching, Chou, Min-Yuan, Chang, Teng-Yuan, Yuan, Shyng-Shiou, Chen, Chiao-Yun, Hou, Ming-Feng, Hsu, John Tsu-An, Wang, Yun-Ming“…The overexpression of HER2/neu and EGFR receptors plays important roles in tumorigenesis and tumor progression. …”
Publicado 2016
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3540por Eralp, Yesim, Wang, Xiaoyan, Wang, Jian-Ping, Maughan, Maureen F, Polo, John M, Lachman, Lawrence B“…METHODS: Mice were injected in the mammary fat pad with an aggressive breast tumor cell line that expresses HER2/neu. The mice were treated 3 days later with a noncurative dose of either doxorubicin or paclitaxel, and the following day with a gene vaccine to HER2/neu. …”
Publicado 2004
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