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  1. 3601
    “…The Cancer Geneome Atlas (TCGA) data was analyzed for HDAC, PI3K, HER2, and MAPK/RAS/RAF gene alterations from sarcoma TCGA. …”
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    Outcomes of patients with sarcoma enrolled in clinical trials of pazopanib combined with histone deacetylase, mTOR, Her2, or MEK inhibitors
  2. 3602
    “…Thus, a substantial improvement over this immunotherapeutic approach could be offered by an anti-HER-3 based Antibody-Drug Conjugate (ADC). In the present paper, we describe the generation of an ADC obtained by coupling the HER-3 targeting antibody EV20 linked to the plant toxin Saporin (Sap). …”
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    EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma
  3. 3603
    “…Disease outcomes of HER2+ breast cancers have dramatically changed after targeted therapies, such as trastuzumab, came to clinical practice but predictive factors for trastuzumab sensitivity and resistance are frequently unknown. …”
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    Prognostic and predictive role of spatially positioned tumour infiltrating lymphocytes in metastatic HER2 positive breast cancer treated with trastuzumab
  4. 3604
    “…Epertinib (S-222611) is a potent, reversible, and selective tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), human EGFR2 (HER2), and human EGFR4. We developed experimental brain metastasis models by intraventricular injection (intraventricular injection mouse model; IVM) of HER2-positive breast cancer (MDA-MB-361-luc-BR2/BR3) or T790M-EGFR-positive lung cancer (NCI-H1975-luc) cells. …”
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    Distribution analysis of epertinib in brain metastasis of HER2-positive breast cancer by imaging mass spectrometry and prospect for antitumor activity
  5. 3605
    “…Furthermore, the interaction between Kpnβ1 and Her2 was clearly observed by immunoprecipitation, indicating that Kpnβ1-knockdown abrogated nuclear transport of Her2. …”
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    Suppression of Kpnβ1 expression inhibits human breast cancer cell proliferation by abrogating nuclear transport of Her2
  6. 3606
    por Daemen, Anneleen, Manning, Gerard
    Publicado 2018
    “…BACKGROUND: Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. …”
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    HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors
  7. 3607
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    The first identification of genomic loci in plants associated with resistance to galling insects: a case study in Eucalyptus L'Hér. (Myrtaceae)
  8. 3608
    “…Specificity was tested in MCF-7(HER3-high), BT474(HER3-high), and 293T(HER3-negative) cells using flow cytometry and confocal microscopy. …”
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    Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity
  9. 3609
    “…The design of active, stable, and cost-effective electrocatalysts for the H(2) evolution reaction (HER) in alkaline conditions is important for electrochemical systems such as the chloro-alkaline process and H(2) production. …”
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    Synergistic effect of nano-Pt and Ni spine for HER in alkaline solution: hydrogen spillover from nano-Pt to Ni spine
  10. 3610
    “…BACKGROUND: The aims of this study were to determine whether the quantitative HER2 gene amplification level is related to the key clinicopathological features that represent the aggressiveness of breast cancer (BC) and to determine whether the quantitative HER2 gene amplification level could predict the treatment response in the subset of HER2-positive patients who received neoadjuvant targeted therapy. …”
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    Clinical significance of quantitative HER2 gene amplification as related to its predictive value in breast cancer patients in neoadjuvant setting
  11. 3611
    “…CASE PRESENTATION: We reported the case of a 39-year-old male patient with HER2-positive gastric cancer with bone and meningeal metastases. …”
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    Rapid symptomatic relief of HER2-positive gastric cancer leptomeningeal carcinomatosis with lapatinib, trastuzumab and capecitabine: a case report
  12. 3612
    “…The correlation between CNB and SE specimens was estimated as 81% and 97.3% for PR and Her-2, respectively. DISCUSSION: CNB can be performed confidently to determine ER and Her-2. …”
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    The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study
  13. 3613
    “…BACKGROUND: Recent studies have shown that tumors with extensive tumor-infiltrating lymphocytes (TILs) have a higher probability of pathologic complete response, even in luminal/human epidermal growth factor 2 (HER2)-negative breast cancer. We compared TIL levels and the 21-gene recurrence score (RS) in estrogen receptor (ER)-positive/HER2-negative breast cancer. …”
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    Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer
  14. 3614
    “…BACKGROUND: Activating EGFR mutations, HER2, and HER3 are implicated in lung cancer; however, with the exception of EGFR gene amplification in lung adenocarcinoma harboring EGFR mutations, their involvement in disease progression during the early stages is poorly understood. …”
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    HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1
  15. 3615
    “…The SFTSV was also identified in the tick that bit her, H. longicornis. Phylogenetic analyses indicated that the SFTSV from the patient and the tick was identical. …”
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    Case report: detection of the identical virus in a patient presenting with severe fever with thrombocytopenia syndrome encephalopathy and the tick that bit her
  16. 3616
    por Ahmed, Ayesha, Al-Tamimi, Dalal M.
    Publicado 2018
    “…Frequency of Ki-67 and p-53 positivity in Her2-neu positive cases was calculated and compared with those in Her2-neu negative cases. …”
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    Incorporation of p-53 mutation status and Ki-67 proliferating index in classifying Her2-neu positive gastric adenocarcinoma
  17. 3617
    Publicado 2018
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    Looking Back at 2017 with ASTMH Past President Patricia Walker: Political Challenges Remind Her that “Optimism is a Moral Imperative”
  18. 3618
    “…EGFR and HER-2 are important targets but none of the monoclonal antibodies or small molecule tyrosine kinase inhibitors specific for the HER members has been approved for the treatment of patients with ovarian cancers. …”
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    Co-expression and prognostic significance of the HER family members, EGFRvIII, c-MET, CD44 in patients with ovarian cancer
  19. 3619
    “…BACKGROUND: Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. …”
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    Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer
  20. 3620
    “…The surrogacy of PFS or time to progression (TTP) for OS has not been formally investigated in HR+, HER2− MBC. METHODS: A systematic literature review of RCTs in HR+, HER2− MBC was conducted to identify studies that reported both median PFS/TTP and OS. …”
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    Progression-free survival/time to progression as a potential surrogate for overall survival in HR+, HER2− metastatic breast cancer
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