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3701por Zheng, Dongdong, Wan, Caifeng, Yang, Hong, Xu, Li, Dong, Qi, Du, Chengrun, Du, Jing, Li, Fenghua“…The targeting evaluation in vitro showed that Her2-DSG NPs could actively target and identify Her2-positive tumor cells. …”
Publicado 2020
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3702por Hüser, Laura, Kokkaleniou, Marianthi-Maria, Granados, Karol, Dworacek, Jennifer, Federico, Aniello, Vierthaler, Marlene, Novak, Daniel, Arkhypov, Ihor, Hielscher, Thomas, Umansky, Viktor, Altevogt, Peter, Utikal, Jochen“…Thus, blocking HER family members and especially HER3 in addition to targeted therapy treatment might prevent the occurrence of resistance. …”
Publicado 2020
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3703por Jenke, Robert, Holzhäuser-Rein, Miriam, Mueller-Wilke, Stefanie, Lordick, Florian, Aigner, Achim, Büch, Thomas“…In this study, we analyzed the role of HER receptors, in particular HER3 and its ligand heregulin, in this respect. …”
Publicado 2020
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3704por Aznab, Mozaffar, Khajevand Ahmady, Meisam, Jamshidi, Khodamrad, Madani, Seyed Hamid, Khazaei, Sedigheh, Shoushtaryzadeh, Tina, Bagheri, Abolfazl“…BACKGROUND: The expression of HER-2neu and vascular endothelial growth factor (VEGF) in patients with osteosarcoma may determine the response to treatment. …”
Publicado 2020
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3705por Landuzzi, Lorena, Palladini, Arianna, Ceccarelli, Claudio, Asioli, Sofia, Nicoletti, Giordano, Giusti, Veronica, Ruzzi, Francesca, Ianzano, Marianna L., Scalambra, Laura, Laranga, Roberta, Balboni, Tania, Arigoni, Maddalena, Olivero, Martina, Calogero, Raffaele A., De Giovanni, Carla, Dall’Ora, Massimiliano, Di Oto, Enrico, Santini, Donatella, Foschini, Maria Pia, Cucchi, Maria Cristina, Zanotti, Simone, Taffurelli, Mario, Nanni, Patrizia, Lollini, Pier-Luigi“…Sequential in vivo passages of PDX-BRB4 chronically treated with trastuzumab developed progressive loss of sensitivity to trastuzumab while HER2 expression and sensitivity to the pan-HER tyrosine kinase inhibitor neratinib were maintained. …”
Publicado 2021
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3706por Rahul, Patley, Chander, K. Rakesh, Murugesan, Manisha, Anjappa, Adarsha Alur, Parthasarathy, Rajani, Manjunatha, Narayana, Kumar, Channaveerachari Naveen, Math, Suresh BadaEnlace del recurso
Publicado 2021
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3707por Acevedo, Nathalie, Scala, Giovanni, Merid, Simon Kebede, Frumento, Paolo, Bruhn, Sören, Andersson, Anna, Ogris, Christoph, Bottai, Matteo, Pershagen, Göran, Koppelman, Gerard H., Melén, Erik, Sonnhammer, Erik, Alm, Johan, Söderhäll, Cilla, Kere, Juha, Greco, Dario, Scheynius, AnnikaEnlace del recurso
Publicado 2021
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3708por Rozenblit, Mariya, Mun, Sophia, Soulos, Pamela, Adelson, Kerin, Pusztai, Lajos, Mougalian, Sarah“…METHODS: Retrospective analysis of electronic health record-derived data for HR+ HER2− metastatic breast cancer from 2012 to 2018. …”
Publicado 2021
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3709por Rocca, Andrea, Cortesi, Pietro, Cortesi, Laura, Gianni, Lorenzo, Matteucci, Federica, Fantini, Lorenzo, Maestri, Antonio, Giunchi, Donata Casadei, Cavanna, Luigi, Ciani, Rosa, Falcini, Fabio, Bagni, Antonella, Meldoli, Elena, Dall’Agata, Monia, Volpi, Roberta, Andreis, Daniele, Nanni, Oriana, Curcio, Annalisa, Lucchi, Leonardo, Amadori, Dino, Fedeli, Anna“…BACKGROUND: The aim of this study was to improve activity over single human epidermal growth factor receptor 2 (HER2)-blockade sequential neaodjuvant regimens for HER2-positive breast cancer, by exploiting the concomitant administration of trastuzumab, taxane and anthracycline, while restraining cardiac toxicity with use of liposomal doxorubicin, and by adding metformin, based on preliminary evidence of antitumor activity. …”
Publicado 2021
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3710por Watanabe, Shin‐nosuke, Imai, Kazuhiro, Nanjo, Hiroshi, Wakamatsu, Yuki, Kimura, Yoshihiko, Katayose, Yoshihisa, Kamata, Shuichi, Terata, Kaori, Takahashi, Eriko, Ibonai, Ayano, Yamaguchi, Ayuko, Konno, Hikari, Yatsuyanagi, Misako, Kudo, Chiaki, Takashima, Shinogu, Akagami, Yoichi, Nakamura, Ryuta, Sato, Yusuke, Motoyama, Satoru, Nomura, Kyoko, Minamiya, Yoshihiro“…BACKGROUND: Human epidermal growth factor receptor 2‐in situ hybridization (HER2‐ISH) is widely approved for diagnostic, prognostic biomarker testing of formalin‐fixed paraffin‐embedded tissue blocks. …”
Publicado 2020
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3711por Erickson, Anders Wilder, Habbous, Steven, Hoey, Christianne, Jerzak, Katarzyna J., Das, Sunit“…This study pooled estimates of IMD incidence and survival among patients with HER2-positive breast cancer receiving dual- versus single-agent HER2 targeted therapy, as well as trastuzumab versus chemotherapy, observation, or another HER2-targeted agent. …”
Publicado 2021
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3712“…Moreover, human epidermal growth factor receptor 2 (HER2) was identified as a novel target of circMAP7D1 in GC, and NFIB was able to increase the stability of HER2 mRNA through regulating circMAP7D1. …”
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3713por Arenas, Enrique J., Martínez-Sabadell, Alex, Rius Ruiz, Irene, Román Alonso, Macarena, Escorihuela, Marta, Luque, Antonio, Fajardo, Carlos Alberto, Gros, Alena, Klein, Christian, Arribas, Joaquín“…Using TCB and CARs directed against HER2, here we show that disruption of interferon-gamma signaling confers resistance to killing by active T lymphocytes. …”
Publicado 2021
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3714por Delgado, J., Vleminckx, C., Sarac, S., Sosa, A., Bergh, J., Giuliani, R., Enzmann, H., Pignatti, F.“…Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate of trastuzumab [a monoclonal antibody against human epidermal growth factor receptor 2 (HER2)] and DM1 (an inhibitor of tubulin polymerisation). …”
Publicado 2021
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3715por Lu, Guangxian, Li, Jianhua, Ding, Leyun, Wang, Chenping, Tang, Lian, Liu, Xin, Xu, Jinhui, Zhou, Qin, Sun, Jiantong, Wang, Wenjuan, Ding, Xinyuan“…It was found that up-regulated UCHL1 expression was positively associated with both chemoresistance and poor prognosis, especially in patients with HER2+ BC. Moreover, UCHL1 expression was elevated in HER2+ BC cells (SK-BR-3 and BT474). …”
Publicado 2021
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3716por Pierpaoli, Elisa, Piacenza, Francesco, Fiorillo, Gaetano, Lombardi, Paolo, Orlando, Fiorenza, Salvatore, Carmela, Geroni, Cristina, Provinciali, Mauro“…Our results demonstrated that IG NAX014 administration delayed the onset of mammary tumors with no negative effects on health and survival. NAX014 reduced HER-2 overexpressing BC cells migration in vitro and the frequency of lung metastasis in HER-2/neu transgenic mice. …”
Publicado 2021
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3717por Wang, Bi-Cheng, Xiao, Bo-Ya, Fan, Ji-Quan, Lin, Guo-He, Wang, Chang, Liu, Quentin, Zhao, Yan-XiaEnlace del recurso
Publicado 2021
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3718por Lee, Kyoungmin, Sim, Sung Hoon, Kang, Eun Joo, Seo, Jae Hong, Chae, Heejung, Lee, Keun Seok, Kim, Ji-Yeon, Ahn, Jin Seok, Im, Young-Hyuck, Park, Seri, Park, Yeon Hee, Park, In Hae“…Methods: We performed a multicenter, retrospective analysis to evaluate the clinical implications of chemotherapy in breast cancer patients with HER2-negative iLRR. Results: Of a total of 277 patients, 146 (52.7%) received chemotherapy for iLRR. …”
Publicado 2021
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3719por Chung, Wei‐Pang, Huang, Wei‐Lun, Liao, Wei‐An, Huang, Wan‐Ling, Liu, You‐Yu, Su, Wu‐Chou“…BACKGROUND: Patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who fail to respond to anti‐HER2 treatments have poor prognoses. …”
Publicado 2021
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3720por Myers, Kyl, Sanders, Jessica N., Dalessandro, Cristen, Sexsmith, Corinne D., Geist, Claudia, Turok, David K.“…METHODS: During the last six months of the HER Salt Lake Contraceptive Initiative (September 2016-March 2017), we introduced an online media campaign designed to connect potential clients to information about the initiative and a brief (9-item) appointment request form (via HERsaltlake.org). …”
Publicado 2021
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