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381Publicado 2015“…The therapeutic strategy of non-small cell lung cancer (NSCLC) is dramatically changed with the introduction of molecular targeted drugs in the last years, resulting in a series of results in histologic and molecular level.The discovery of epidermal growth factor receptor (EGFR) mutation, Kirsten rat sarcoma (KRAS) viral oncogene mutation and anaplastic lymphoma kinase (ALK) rearrangement, has profoundly influenced the development of treatment of NSCLC.Recently, there is a renewed interest in the human epidermal growth receptor 2 (HER2), where genetic alteration in NSCLC is associated with the different sensetivity of EGFR tyrosine kinase inhibitors (TKIs), to have a prognostic effect.HER2 amplification in EGFR mutation tumors may become a mechanism of acquired resistance to the TKIs.Besides, HER2 mutation may become a novel therapeutic strategy of NSCLC.…”
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382por Creemers, Aafke, Ebbing, Eva A., Hooijer, Gerrit K.J., Stap, Lisanne, Jibodh-Mulder, Rajni A., Gisbertz, Susanne S., van Berge Henegouwen, Mark I., van Montfoort, Maurits L., Hulshof, Maarten C.C.M., Krishnadath, Kausilia K., van Oijen, Martijn G.H., Bijlsma, Maarten F., Meijer, Sybren L., van Laarhoven, Hanneke W.M.“…Trastuzumab, a monoclonal antibody against HER2, has become standard of care for metastatic HER2-overexpressing esophagogastric adenocarcinoma and is currently investigated as (neo)adjuvant treatment option in HER2-positive esophagogastric adenocarcinoma. …”
Publicado 2018
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383por Mishra, Rosalin, Alanazi, Samar, Yuan, Long, Solomon, Thomas, Thaker, Tarjani M., Jura, Natalia, Garrett, Joan T.“…Recent studies have highlighted a role of HER3 in ER and HER2-driven breast cancers. We sought to investigate the role of patient-derived HER3 mutations in ER+ and HER2+ breast cancer cells using ectopic expression of HER3 mutants. …”
Publicado 2018
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384por Chang, Ke-VinEnlace del recurso
Publicado 2017
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385por Chang, Ke-VinEnlace del recurso
Publicado 2017
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386“…ERBB family members including epidermal growth factor receptor (EGFR) also known as HER1, ERBB2/HER2/Neu, ERBB3/HER3 and ERBB4/HER4 are aberrantly activated in multiple cancers and hence serve as drug targets and biomarkers in modern precision therapy. …”
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388por Duan, Yufeng, Li, Xuebing, Zhang, Sicheng, Wang, Shikai, Wang, Tao, Chen, Hong, Yang, Yan, Jia, Sixun, Chen, Guoqing, Tian, Weidong“…Based on these characteristics, HERS cell is a potential seed cell type for tooth-related tissue regeneration. …”
Publicado 2020
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389por Zheng, Mengmeng, Li, Chunpu, Zhou, Mi, Jia, Ru, She, Fengyu, Wei, Lulu, Cheng, Feng, Li, Qi, Cai, Jianfeng, Wang, Yan“…In this study, we reported a strategy for the development of artificial antibody based on γ-AApeptides to target HER2 extracellular domain (ECD). To achieve this, we synthesized a one-bead-two-compound (OBTC) library containing 320,000 cyclic γ-AApeptides, from which we identified a γ-AApeptide, M-3-6, that tightly binds to HER2 selectively. …”
Publicado 2021
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390“…The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is expressed in several types of tumors. …”
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395por Bai, Xue, Sun, Pengyu, Wang, Xinghao, Long, Changkun, Liao, Shuyun, Dang, Song, Zhuang, Shangshang, Du, Yongtao, Zhang, Xinyi, Li, Nan, He, Kangmin, Zhang, Zhe“…HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. …”
Publicado 2023
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398por Yorozu, Keigo, Kurasawa, Mitsue, Iino, Yuki, Nakamura, Yuka, Hashizume, Kaoru, Harada, Naoki, Ochiai, Atsushi“…Gene amplification and protein overexpression of human epidermal growth factor receptor type 2 (HER2) are specific targets for HER2‐targeting drugs in breast, gastric, salivary gland, and colorectal cancers. …”
Publicado 2022
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399por Han, Yanjie, Xiong, Yuanyuan, Lu, Tao, Chen, Rongrong, Liu, Yuan, Tang, Hui, Geng, Ruixuan, Wang, Yingyi“…BACKGROUND: HER2-targeted therapy provides survival benefits to HER2-mutant non-small cell lung cancer (NSCLC). …”
Publicado 2023
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