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501“…BACKGROUND: Conflicting data exist about the prevalence of HER-2/neu overexpression in colorectal cancer ranging from 0 to 83 %. …”
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502“…We also discuss novel therapies that may improve the efficacy of trastuzumab, and that offer hope that the survival of breast cancer patients with HER2-overexpressing tumors can be vastly improved.…”
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508“…Amplification of the HER2 gene and/or overexpression of its protein product have been found in up to 25% to 30% of human breast cancers and have been shown to be associated with poorer outcomes compared to ‘HER2 normal’ breast cancer. …”
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509por Lorusso, Vito“…Phase 1/2 trials showed significant antitumor effects of bevacizumab in MBC, in particular in tumors not expressing HER2 receptor. A first phase 3 trial in pre-treated MBC patients showed better response rates but no survival benefit from the addition of bevacizumab to capecitabine. …”
Publicado 2008
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511“…Of these, human epidermal growth factor receptor 2 (HER2) is currently in the spotlight. In this review, we provide an overview of recent developments in HER2 testing and results of clinical trials targeting HER2 in gastroesophageal adenocarcinoma. …”
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513por Göstring, Lovisa, Malm, Magdalena, Höidén-Guthenberg, Ingmarie, Frejd, Fredrik Y., Ståhl, Stefan, Löfblom, John, Gedda, Lars“…In addition, both molecules suppressed HRG-induced HER3 and HER2 phosphorylation in MCF-7 cells, as well as HER3 phosphorylation in constantly HER2-activated SKBR-3 cells. …”
Publicado 2012
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514“…This article reviews the data presented at 2012 American Society of Clinical Oncology and 2012 San Antonio Breast Cancer Symposium regarding progress made in the field of HER2 positive breast cancer and examines the future of HER2 targeted therapy.…”
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515“…Preclinical studies have established that CD8(+) T cells are necessary for efficient immunotherapeutic regimens targeting v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2, best known as HER2/Neu). Recently, we extended upon these findings by demonstrating that anti-HER2/Neu therapy also requires CD4(+) T cells and CD40/CD40L signaling within the tumor microenvironment. …”
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516por Patterson, Andrea, Bardet, Wilfried, Jackson, Ken, Weidanz, Jon, Hildebrand, WilliamEnlace del recurso
Publicado 2013
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517por Ingold Heppner, B, Behrens, H-M, Balschun, K, Haag, J, Krüger, S, Becker, T, Röcken, C“…BACKGROUND: Anti-HER2/neu therapy is well-established in breast and gastric carcinoma. …”
Publicado 2014
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518“…ERBB3/HER3 is emerging as a molecular target for various cancers. …”
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