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5501por Alkeraye, Salim, AlMuqrin, Abdullah, AlQahtani, Sami Mufleh, AlSwayyed, Mohammed, Alhuzimi, Abdulrahman“…It was first reported by Nagashima in 1971, and recently, more cases have been reported We introduce a case of a young Saudi female who developed biopsy proved prurigo pigmentosa after she followed strict ketogenic diet. Her condition resolved after she resumed a regular diet.…”
Publicado 2019
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5502por Kang, Young-Joon, Lee, Han-Byoel, Kim, Yun Gyoung, Han, JaiHong, Kim, Yumi, Yoo, Tae-Kyung, Lee, Eun-Shin, Moon, Hyeong-Gon, Noh, Dong-Young, Han, Wonshik“…The goal of this study is to show the prognostic value of Ki-67 according to progesterone receptor (PgR) expression in patients who have estrogen receptor- (ER-) positive, human epidermal growth factor receptor 2- (HER2-) negative early breast cancer. METHODS: The records of nonmetastatic invasive breast cancer patients who underwent surgery at a single institution between 2009 and 2012 were reviewed. …”
Publicado 2019
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5503por Sim, Sung Hoon, Park, In Hae, Jung, Kyung Hae, Kim, Sung-Bae, Ahn, Jin-Hee, Lee, Kyung-Hun, Im, Seock-Ah, Im, Young-Hyuck, Park, Yeon Hee, Sohn, Joohyuk, Kim, Yu Jung, Lee, Suee, Kim, Hee-Jun, Chae, Yee Soo, Park, Kyong Hwa, Nam, Byung-Ho, Lee, Keun Seok, Ro, Jungsil“…BACKGROUND: The continuum of anti-HER2 agents is a standard treatment of HER2 + metastatic breast cancer (MBC). …”
Publicado 2019
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5504por Kim, Yu-Jin, Lee, Gyunghwa, Han, Jinil, Song, Kyoung, Choi, Joon-Seok, Choi, Yoon-La, Shin, Young Kee“…We previously showed that UBE2C mRNA expression is significantly associated with poor prognosis only in patients with hormone receptor (HR)+/human epidermal growth factor receptor 2 (HER2)– breast cancer. In this study, we further reanalyzed the correlation between UBE2C mRNA expression and clinical outcomes in patients with HR+/HER2– breast cancer, and we investigated the molecular mechanism underlying the role of UBE2C modulation in disease progression in this subgroup of patients. …”
Publicado 2020
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5505por Soliman, Hatem, Wagner, Susanne, Flake, Darl D., Robson, Mark, Schwartzberg, Lee, Sharma, Priyanka, Magliocco, Anthony, Kronenwett, Ralf, Lancaster, Johnathan M., Lanchbury, Jerry S., Gutin, Alexander, Gradishar, William“…RESULTS: Expression data were available for 764 ER-positive, HER2-negative breast cancer samples, including 59 patients with pCR. …”
Publicado 2020
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5506“…Purpose: Both 12 and 6 months of trastuzumab in combination with chemotherapy are effective for HER2+ early-stage breast cancer. This meta-analysis was performed to assess the effectiveness and the toxicity of the two durations. …”
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5507por Cędrowska, Edyta, Pruszyński, Marek, Gawęda, Weronika, Żuk, Michał, Krysiński, Paweł, Bruchertseifer, Frank, Morgenstern, Alfred, Karageorgou, Maria-Argyro, Bouziotis, Penelope, Bilewicz, Aleksander“…The synthesized (225)Ac@Fe(3)O(4)-CEPA-trastuzumab bioconjugates have shown a high cytotoxic effect toward SKOV-3 ovarian cancer cells expressing HER2 receptor in-vitro. The in-vivo studies indicate that this bioconjugate exhibits properties suitable for the treatment of cancer cells by intratumoral or post-resection injection. …”
Publicado 2020
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5508por Wu, Xiao-Xiao, Yue, Grace Gar-Lee, Dong, Jin-Run, Lam, Christopher Wai-Kei, Wong, Chun-Kwok, Qiu, Ming-Hua, Lau, Clara Bik-San“…HER2-positive breast cancer accounts for 15–20% in breast cancer and 50% of the metastatic HER2-positive breast cancer patients died of central nervous system progression. …”
Publicado 2020
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5509por Hojan, Katarzyna, Procyk, Danuta, Horyńska-Kęstowicz, Dorota, Leporowska, Ewa, Litwiniuk, Maria“…To conclude, moderate-intensity exercise training prevented a decrease in the LVEF and physical capacity during trastuzumab therapy in HER2+ BC. Further research is needed to validate our results.…”
Publicado 2020
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5510“…BACKGROUND: Overexpression of human epidermal growth factor receptor 2 (HER2) is associated with aggressive disease and poor prognosis. …”
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5511por Inoue, Kenichi, Takahashi, Masato, Mukai, Hirofumi, Yamanaka, Takashi, Egawa, Chiyomi, Sakata, Yukinori, Ikezawa, Hiroki, Matsuoka, Toshiyuki, Tsurutani, Junji“…Thus, these suggest eribulin may be a first-line treatment candidate for patients with HER2-negative advanced breast cancer in Japan.…”
Publicado 2020
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5512por Rugo, Hope S., Dieras, Veronique, Cortes, Javier, Patt, Debra, Wildiers, Hans, O’Shaughnessy, Joyce, Zamora, Esther, Yardley, Denise A., Carter, Gebra Cuyun, Sheffield, Kristin M., Li, Li, Andre, Valerie A. M., Li, Xiaohong I., Frenzel, Martin, Huang, Yu-Jing, Dickler, Maura N., Tolaney, Sara M.“…PURPOSE: In MONARCH 1 (NCT02102490), single-agent abemaciclib demonstrated promising efficacy activity and tolerability in a population of heavily pretreated women with refractory HR+, HER2− metastatic breast cancer (MBC). To help interpret these results and put in clinical context, we compared overall survival (OS) and duration of therapy (DoT) between MONARCH 1 and a real-world single-agent chemotherapy cohort. …”
Publicado 2020
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5513por Cohen, Shabtai, Koltai, Hinanit, Selvaraj, Gopinath, Mazuz, Moran, Segoli, Moran, Bustan, Amnon, Guy, Ofer“…Hairy stork’s bill (Erodium crassifolium L’Hér), is a small hemicryptophyte that inhabits arid southeast Mediterranean regions. …”
Publicado 2020
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5514por Lee, In Hee, Lee, Soo Jung, Lee, Jeeyeon, Jung, Jin Hyang, Park, Ho Yong, Jeong, Shin Young, Lee, Sang-woo, Chae, Yee Soo“…In patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2) -negative breast cancer, the response to NAC is variable and mostly limited. …”
Publicado 2020
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5515por Thanopoulou, Eirini, Khader, Leila, Caira, Morena, Wardley, Andrew, Ettl, Johannes, Miglietta, Federica, Neven, Patrick, Guarneri, Valentina“…A growing body of evidence suggests that hormone receptor-positive (HR+)/HER2+ BC and HR-negative (HR−)/HER2+ BC are biologically different, with complex molecular bidirectional crosstalk between the estrogen receptor and HER2 pathway potentially affecting sensitivity to both HER2-targeted and endocrine therapy in patients with HR+/HER2+ BC. …”
Publicado 2020
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5516por Zhao, Yannan, Li, Yi, Gong, Chengcheng, Xie, Yizhao, Zhang, Jian, Wang, Leiping, Cao, Jun, Tao, Zhonghua, Wang, Biyun, Hu, XichunEnlace del recurso
Publicado 2020
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5517por Naghibi, Laleh, Yazdani, Mona, Momtazi-Borojeni, Amir Abbas, Razazan, Atefeh, Shariat, Sheida, Mansourian, Mercedeh, Arab, Atefeh, Barati, Nastaran, Arabsalmani, Mahdieh, Abbasi, Azam, Saberi, Zahra, Badiee, Ali, Jalali, Seyed Amir, Jaafari, Mahmoud Reza“…HER2/neu is an immunogenic protein inducing both humoral and cell-mediated immune responses. …”
Publicado 2020
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5518por Sharma, Manvi, Arora, Itika, Stoll, Matthew L., Li, Yuanyuan, Morrow, Casey D., Barnes, Stephen, Berryhill, Taylor F., Li, Shizhao, Tollefsbol, Trygve O.“…We evaluated the impact of broccoli sprouts (BSp), green tea polyphenols (GTPs) and their combination on the gut microbiota and SCFAs metabolism from the microbiota in Her2/neu transgenic mice that spontaneously develop estrogen receptor-negative [ER(-)] mammary tumors. …”
Publicado 2020
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5519por Chen, Kaiyan, Pan, Guoqiang, Cheng, Guoping, Zhang, Fanrong, Xu, Yanjun, Huang, Zhiyu, Fan, Yun“…This study aimed to investigate the immune microenvironment features and efficacy of PD‐1/PD‐L1 blockade of NSCLC with EGFR and HER2 Ex20ins. METHODS: Clinical characteristics, coexisting mutations, and outcomes to EGFR‐TKIs and immune checkpoint blockade were reviewed for NSCLC patients with exon 20 mutations of EGFR or HER2. …”
Publicado 2020
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5520por Roberto, Michela, Astone, Antonio, Botticelli, Andrea, Carbognin, Luisa, Cassano, Alessandra, D’Auria, Giuliana, Fabbri, Agnese, Fabi, Alessandra, Gamucci, Teresa, Krasniqi, Eriseld, Minelli, Mauro, Orlandi, Armando, Pantano, Francesco, Paris, Ida, Pizzuti, Laura, Portarena, Ilaria, Salesi, Nello, Scagnoli, Simone, Scavina, Paola, Tonini, Giuseppe, Vici, Patrizia, Marchetti, Paolo“…ABSTRACT: Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer is the most common breast cancer subtype, and endocrine therapy (ET) remains its therapeutic backbone. …”
Publicado 2021
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