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56161por Bartáková, Vendula, Barátová, Beáta, Chalásová, Katarína, Janků, Petr, Kaňková, Kateřina“…BACKGROUND: Gestational diabetes mellitus (GDM) represents a risk factor for both mother and her offspring in a short-term (perinatal morbidity) and long-term horizon (postpartum diabetes or foetal programming). …”
Publicado 2022
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56162por Aimar, Giacomo, Paratore, Chiara, Zichi, Clizia, Marino, Donatella, Sperti, Elisa, Caglio, Andrea, Gamba, Teresa, De Vita, Francesca, Di Maio, Massimo“…Nine (13.4%) clinical trials tested human epidermal growth factor receptor (HER) 2 targeting therapy. Four (44.4%) studies are phase I trials, two (22.2%) are phase I/II trials, and three (33.3%) phase II trials. …”
Publicado 2021
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56163por Puhalla, Shannon L., Diéras, Véronique, Arun, Banu K., Kaufman, Bella, Wildiers, Hans, Han, Hyo S., Ayoub, Jean-Pierre, Stearns, Vered, Yuan, Yuan, Helsten, Teresa, Riley-Gillis, Bridget, Murphy, Erin, Kundu, Madan G., Wu, Meijing, Maag, David, Ratajczak, Christine K., Ramathal, Cyril Y., Friedlander, Michael“…PURPOSE: Safety, efficacy, and exploratory biomarker analyses were evaluated in patients with advanced HER2-negative germline breast cancer susceptibility gene (gBRCA)-associated breast cancer enrolled in the BROCADE3 trial who received crossover veliparib monotherapy after disease progression on placebo plus carboplatin/paclitaxel. …”
Publicado 2021
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56164“…SIMPLE SUMMARY: Triple-negative breast cancers lack estrogen and progesterone receptors and HER2. They lack effective targeted therapies and tend to be more aggressive, with the worst five-year overall survival and a higher rate of recurrence. …”
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56165por Freiberger, Annika, Beckmann, Jürgen, Freilinger, Sebastian, Kaemmerer, Harald, Huber, Maximilian, Nagdyman, Nicole, Ewert, Peter, Pieper, Lars, Deppe, Charlotte, Kuschel, Bettina, Andonian, Caroline“…CONCLUSIONS: Postpartum mental health problems, such as (postpartum) depression, anxiety, and posttraumatic stress can become a serious burden which might be detrimental to the mother’s well-being and her infant’s development. Present findings emphasise the urgent need for a holistic approach focusing on pregnant women with CHD starting at the prepartum stage to prevent adverse consequences and promote maternal well-being. …”
Publicado 2022
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56166por Veličković, Katarina, Borrebaeck, Carl A. K., Bendahl, Pär-Ola, Hegardt, Cecilia, Johnsson, Per, Richter, Corinna, Rydén, Lisa, Hallberg, Ingalill Rahm“…Patients with a higher TNM stage and histologic grade and estrogen receptor (ER)-negative and human epidermal growth factor 2 (HER2)-positive status, who received chemotherapy, antibody therapy, or bisphosphonate therapy, had a steeper decline in outcomes. …”
Publicado 2022
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56167por Martinelli, Valéria Ferreira, Martinelli Barbosa, Pedro, Dantas de Oliveira, Lucila Samara, de Melo, Luísa de Andrade Lima Vieira, Casa Nova, João Manoel, de Brito, Carlos Alexandre Antunes“…A 25-year-old patient with ulcerative colitis presented an extensive chronic ulcerative lesion on her left leg that was associated with significant bleeding; the intestinal disease was in remission under the use of azathioprine. …”
Publicado 2022
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56168“…There were, however, distinct differences in immune-related gene expression patterns in basal-like tumors between the two species. Characteristic HER2-enriched and luminal B subtypes were not present in the canine cohort, and we found no tumors with high-level ERBB2 amplifications. …”
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56169por Menon, Ramkumar“…Human pregnancy is a delicate and complex process where multiorgan interactions between two independent systems, the mother, and her fetus, maintain pregnancy. Intercellular interactions that can define homeostasis at the various cellular level between the two systems allow uninterrupted fetal growth and development until delivery. …”
Publicado 2022
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56170“…The mass was completely excised, and histopathologic examination confirmed the diagnosis. Her recovery was uneventful. She was informed about the diagnosis, reassured, and discharged from care. …”
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56171“…The variables, including T-stage, distant metastasis, and expression of HER2, were associated with the value of D-dimer. …”
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56172por Chen, Yuanying, Sun, Qiqing, Hao, Chanjuan, Guo, Ruolan, Wang, Chentong, Yang, Weili, Zhang, Yaodong, Wang, Fangjie, Li, Wei, Guo, Jun“…METHODS: We performed whole exome sequencing in a 12-year-old girl with non-syndromic DCM and her unaffected parents. Variants in both known DCM-related genes and novel candidate genes were analyzed and pathogenicity confirmation experiments were performed. …”
Publicado 2022
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56173“…BACKGROUND: Triple-positive breast cancer (TPBC) is a specific type of breast cancer characterized by the positive expression of estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER-2). In recent years, the research on breast cancer has been increasing year by year, but there are few studies on TPBC, especially the lack of analysis with large sample size. …”
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56174“…Physical examination revealed a friable, polyp-like mass (5 cm × 5 cm) in her cervix protruding into the vagina, while the uterus was mobile and normal-sized. …”
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56175por Galactionova, Katya, Loibl, Sibylle, Salari, Paola, Marmé, Frederik, Martin, Miguel, Untch, Michael, Bonnefoi, Hervé R., Kim, Sung-Bae, Bear, Harry D., McCarthy, Nicole, Gelmon, Karen A., García-Sáenz, José A., Kelly, Catherine M., Reimer, Toralf, Toi, Masakazu, Rugo, Hope S., Gnant, Michael, Makris, Andreas, Burchardi, Nicole, Schwenkglenks, Matthias“…BACKGROUND: Patients with hormone receptor-positive, HER2-negative breast cancer who have residual invasive disease after neoadjuvant chemotherapy (NACT) are at a high risk of relapse. …”
Publicado 2022
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56176“…The review suggests that while planned VBAC compared to ERCS is associated with an increased risk of various serious birth-related complications for both the mother and her baby, the absolute risk of these complications is small for either birth approach. …”
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56177por Berdunov, Vladislav, Millen, Steve, Paramore, Andrew, Griffin, Jane, Reynia, Sarah, Fryer, Nina, Brown, Rebecca, Longworth, Louise“…BACKGROUND: The 21-gene assay (the Oncotype DX Breast Recurrence Score(®) test) is a validated multigene assay which produces the Recurrence Score(®) result (RS) to inform decisions on the use of adjuvant chemotherapy in human epidermal growth factor receptor 2-negative (HER2-), hormone receptor positive (HR+) early invasive breast cancer. …”
Publicado 2022
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56178por Zandvakili, Arya, Kobayashi, Takaaki, Kaewpoowat, Quanhathai, Parsons, Meredith G., Ford, Bradley, Barker, Jason H., Johnson, Melinda“…She was diagnosed with TB meningitis, peritonitis, endometritis, and tubo-ovarian abscesses. Her treatment course was complicated by a paradoxical response resulting in a spinal tuberculoma causing lower extremity weakness. …”
Publicado 2022
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56179“…Gly220Profs*95)) was identified in the proband but was not detected in her healthy parents. CONCLUSION: A novel phenotype characterized by unilateral buphthalmos, corneal staphyloma and corneal fistula in an infant were reported to be associated with PITX3 in our study. …”
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56180por Beesley, Richard“…ACKNOWLEDGEMENTS: Thanks to Prof Helen Foster for her vital role in the initial development of these resources, and to all those involved in the development and pilot testing.…”
Publicado 2022
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