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56441por Pierga, J-Y, Reis-Filho, J S, Cleator, S J, Dexter, T, MacKay, A, Simpson, P, Fenwick, K, Iravani, M, Salter, J, Hills, M, Jones, C, Ashworth, A, Smith, I E, Powles, T, Dowsett, M“…Losses of 5q33.3–q4 and 18p11.31 and gains of 6p25.1–p25.2 and Xp11.4 were associated with HER2 amplification. No correlations between DNA copy number changes and clinical response to AC were found. …”
Publicado 2007
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56442por Shetty, A, Loddo, M, Fanshawe, T, Prevost, A T, Sainsbury, R, Williams, G H, Stoeber, K“…Protein expression profiles were generated for Ki67, Mcm2, geminin, HER-2, ER and PR in a series of reduction mammoplasty (n=18) and breast cancer specimens (n=120), and compared to clinicopathological parameters. …”
Publicado 2005
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56443por Miyazono, F, Metzger, R, Warnecke-Eberz, U, Baldus, S E, Brabender, J, Bollschweiler, E, Doerfler, W, Mueller, R P, Dienes, H P, Aikou, T, Hoelscher, A H, Schneider, P M“…We examined the potential of quantitative epidermal growth factor receptor (EGFR, synonym: c-erbB-1) and c-erbB-2 (synonym: HER2/neu) mRNA expression to predict minor or major histopathologic response to neoadjuvant radiochemotherapy (cis-platinum, 5-FU, 36 Gy), followed by radical surgical resection, in patients with oesophageal cancer. …”
Publicado 2004
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56444por Montagna, E, Bagnardi, V, Rotmensz, N, Rodriguez, J, Veronesi, P, Luini, A, Intra, M, Scarano, E, Cardillo, A, Torrisi, R, Viale, G, Goldhirsch, A, Colleoni, M“…The worst RFS was observed for the subgroup of patients with endocrine nonresponsive and HER2-negative breast cancer (2-year RFS: 57% in NIBC and 57% in IBC) A high Ki-67 labelling index (>20% of the invasive tumour cells) and the presence of peritumoral vascular invasion (PVI) significantly correlated with poorer RFS in overall (HR 2.69, 95% CI: 1.61–4.50 for Ki-67>20% and HR 2.27, 95% CI: 1.42–3.62 for PVI). …”
Publicado 2008
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56445por Robinson, M K, Hodge, K M, Horak, E, Sundberg, Å L, Russeva, M, Shaller, C C, von Mehren, M, Shchaveleva, I, Simmons, H H, Marks, J D, Adams, G P“…Inappropriate signalling through the EGFR and ErbB2/HER2 members of the epidermal growth factor family of receptor tyrosine kinases is well recognised as being causally linked to a variety of cancers. …”
Publicado 2008
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56446por Miettunen, Paivi MH, Wei, Xingchang, Kaura, Deepak, Reslan, Walid Abou, Aguirre, Alberto Nettel, Kellner, James D“…No patient flared while his/her uNTX/uCr remained suppressed. We propose that pamidronate is an effective second-line therapy in persistent CRMO.…”
Publicado 2009
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56447“…She fell very sick and I came out of school for a full term to look after her. I was treating Jjajja but she was not getting better. …”
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56448por Stefansson, Olafur Andri, Jonasson, Jon Gunnlaugur, Johannsson, Oskar Thor, Olafsdottir, Kristrun, Steinarsdottir, Margret, Valgeirsdottir, Sigridur, Eyfjord, Jorunn Erla“…Tumour phenotypes were analysed by immunohistochemistry on tissue microarrays using selected biomarkers (ER, PR, HER-2, EGFR, CK5/6, CK8, CK18). RESULTS: Classification of genomic profiles through cluster analysis revealed four subgroups, three of which displayed high genomic instability indices (GII). …”
Publicado 2009
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56449por de Haan, M C, Michels, K B, Peeters, P H M, van Noord, P A H, Hennekam, F A M, van der Schouw, Y T“…BACKGROUND: On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter. …”
Publicado 2010
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56450por Mavaddat, Nasim, Pharoah, Paul D, Blows, Fiona, Driver, Kristy E, Provenzano, Elena, Thompson, Deborah, MacInnis, Robert J, Shah, Mitul, Easton, Douglas F, Antoniou, Antonis C“…METHODS: We computed breast cancer FRR for subtypes of breast cancer by comparing breast cancer incidence in relatives of breast cancer cases from a population-based series with known estrogen receptor (ER), progesterone receptor (PR) or human epidermal growth factor receptor 2 (HER2) status with that expected from the general population. …”
Publicado 2010
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56451por Kristiansen, G, Rose, M, Geisler, C, Fritzsche, F R, Gerhardt, J, Lüke, C, Ladhoff, A-M, Knüchel, R, Dietel, M, Moch, H, Varga, Z, Theurillat, J-P, Gorr, T A, Dahl, E“…In addition, 917 invasive and 155 non-invasive breast cancer cases were analysed by immunohistochemistry for Mb expression and correlated to clinicopathological parameters and basal molecular characteristics including oestrogen receptor-α (ERα)/progesteron receptor (PR)/HER2, fatty acid synthase (FASN), hypoxia-inducible factor-1α (HIF-1α), HIF-2α, glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX). …”
Publicado 2010
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56452por Teschendorff, Andrew E, Gomez, Sergio, Arenas, Alex, El-Ashry, Dorraya, Schmidt, Marcus, Gehrmann, Mathias, Caldas, Carlos“…RESULTS: We show that in ER negative basal and HER2+ breast cancer, gene expression modules reflecting T-cell helper-1 (Th1) and T-cell helper-2 (Th2) mediated immune responses play antagonistic roles as major risk factors for distant metastasis. …”
Publicado 2010
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56453“…CHIP is implicated in the modulation of estrogen receptor (ESR1) and Her-2/neu (ERBB2) stability. LOX (lysyl-oxidase) serves intracellular roles and catalyses the cross-linking of extracellular matrix (ECM) collagens and elastin. …”
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56454por Srinivasan, Rahul, Pantoja, Rigo, Moss, Fraser J., Mackey, Elisha D.W., Son, Cagdas D., Miwa, Julie, Lester, Henry A.“…Clinical literature documents an inverse relationship between a person’s history of tobacco use and his or her susceptibility to Parkinson’s disease; this may also result from up-regulation. …”
Publicado 2011
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56455por Yau, Christina, Esserman, Laura, Moore, Dan H, Waldman, Fred, Sninsky, John, Benz, Christopher C“…Hormone receptor negative (HRneg) breast cancers, particularly those lacking HER2/ErbB2 overexpression and known as triple-negative (Tneg) cases, are heterogeneous and generally aggressive breast cancer subsets in need of prognostic subclassification, since most early stage HRneg and Tneg breast cancer patients are cured with conservative treatment yet invariably receive aggressive adjuvant chemotherapy. …”
Publicado 2010
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56456por Loisel, Séverine, André, Pierre-Alain, Golay, Josee, Buchegger, Franz, Kadouche, Jean, Cérutti, Martine, Bologna, Luca, Kosinski, Marek, Viertl, David, Delaloye, Angelika Bischof, Berthou, Christian, Mach, Jean-Pierre, Boumsell, Laurence“…However, despite the significant success of therapy in breast and ovarian carcinomas with anti-HER2 mAbs as well as in non-Hodkin B cell lymphomas with anti-CD20 mAbs, certain B cell malignancies such as B chronic lymphocytic leukaemia (B-CLL) respond poorly to anti-CD20 mAb, due to the low surface expression of this molecule. …”
Publicado 2011
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56457
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56458por Thompson, Patricia A., Brewster, Abenaa M., Kim-Anh, Do, Baladandayuthapani, Veerabhadran, Broom, Bradley M., Edgerton, Mary E., Hahn, Karin M., Murray, James L., Sahin, Aysegul, Tsavachidis, Spyros, Wang, Yuker, Zhang, Li, Hortobagyi, Gabriel N., Mills, Gordon B., Bondy, Melissa L.“…In addition, the full model containing 19 CNIs significantly improved prognostication separately for ER–, HER2+, luminal B, and triple negative tumors over clinical variables alone. …”
Publicado 2011
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56459por Wainberg, Z A, Lin, L-S, DiCarlo, B, Dao, K M, Patel, R, Park, D J, Wang, H-J, Elashoff, R, Ryba, N, Hecht, J R“…The frequency of alterations was KRAS mutations (8%), EGFR mutations (0%) and HER2 amplification (19%). CONCLUSION: In patients with Eso/GEJ adenocarcinoma, mFOLFOX6 and erlotinib is active, has an acceptable toxicity profile and FOLFOX±erlotinib could be considered for further development.…”
Publicado 2011
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56460por Peurala, Hanna, Greco, Dario, Heikkinen, Tuomas, Kaur, Sippy, Bartkova, Jirina, Jamshidi, Maral, Aittomäki, Kristiina, Heikkilä, Päivi, Bartek, Jiri, Blomqvist, Carl, Bützow, Ralf, Nevanlinna, Heli“…High miR-34a expression associated with poor prognostic factors for breast cancer: positive nodal status (p = 0.006), high tumour grade (p<0.0001), ER-negativity (p = 0.0002), HER2-positivity (p = 0.0002), high proliferation rate (p<0.0001), p53-positivity (p<0.0001), high cyclin E (p<0.0001) and γH2AX (p<0.0001). …”
Publicado 2011
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