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56661por Williams, Lindsay A., Butler, Ebonee N., Sun, Xuezheng, Allott, Emma H., Cohen, Stephanie M., Fuller, Ashley M., Hoadley, Katherine A., Perou, Charles M., Geradts, Joseph, Olshan, Andrew F., Troester, Melissa A.“…Mutant-like TP53 (RNA) was strongly associated with age ≤50 years, high tumor grade, advanced stage of disease, large tumor size, and basal-like and HER2 intrinsic subtypes. Black race was strongly associated with TP53 mutant-like status (RNA) (RFD: 24.8%, 95% CI: 20.5, 29.0) even after adjusting for age, grade, stage (RFD: 11.3%; 95% CI: 7.6, 15.0). …”
Publicado 2018
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56662por Zoppino, Felipe C. M., Guerrero-Gimenez, Martin E., Castro, Gisela N., Ciocca, Daniel R.“…Data were stratified according to the PAM50 gene expression (Luminal A, Luminal B, HER2, Basal, and Normal-like). Transcriptomic analyses include several statistical approaches: differential gene expression, hierarchical clustering and survival analysis. …”
Publicado 2018
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56663por Slaoui, Meriem, Zoure, Abdou Azaque, Mouh, Fatima Zahra, Bensouda, Youssef, El Mzibri, Mohammed, Bakri, Youssef, Amrani, Mariam“…The most prevalent molecular subtype was Luminal A (38.7%) followed by Luminal B HER2+ (27.9%) and Triple negative (21.6%). During the follow-up period, 72 patients (32.9%) had recurrence and 40 patients (18.3%) died. …”
Publicado 2018
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56664por Iorio, Jessica, Meattini, Icro, Bianchi, Simonetta, Bernini, Marco, Maragna, Virginia, Dominici, Luca, Casella, Donato, Vezzosi, Vania, Orzalesi, Lorenzo, Nori, Jacopo, Livi, Lorenzo, Arcangeli, Annarosa, Lastraioli, Elena“…Also, a p value close to significance was noticed for the association between hERG1 and HER2 expression (p = 0.079). At the survival analysis, patients with high hERG1 expression turned out to have a longer progression-free survival, although statistical significance was not reached (p = 0.195). …”
Publicado 2018
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56665por Nushtaeva, Anna A., Stepanov, Grigory A., Semenov, Dmitry V., Juravlev, Evgeny S., Balahonova, Evgenia A., Gerasimov, Alexey V., Sidorov, Sergey V., Savelyev, Eugeniy I., Kuligina, Elena V., Richter, Vladimir A., Koval, Olga A.“…Expression of the progesterone receptor (PGR), oestrogen receptor (ER) α and β, human epidermal growth factor receptor (HER) 2 and 3 and aromatase CYP19, as well as expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) mRNA in human breast cells were characterized. …”
Publicado 2018
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56666“…RESULTS: The proband was identified via newborn screening (NBS); whereas, her elder brother, who had not undergone expanded NBS, was diagnosed later through genetic family screening. …”
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56667por Lohmann, Ana Elisa, Dowling, Ryan J O, Ennis, Marguerite, Amir, Eitan, Elser, Christine, Brezden-Masley, Christine, Vandenberg, Theodore, Lee, Elma, Fazaee, Kamran, Stambolic, Vuk, Goodwin, Pamela J, Chang, Martin C“…The cohort included hormone receptor–positive (87.5%), HER2–positive (15.6%), and triple-negative (10.4%) BCs. …”
Publicado 2018
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56668por Tan, Shuqian, Wang, Yang, Liu, Pingping, Ge, Yang, Li, Aomei, Xing, Yongjie, Hunter, David M., Shi, Wangpeng“…Importance: Mother Nature always grants wisdom to her creatures and feeds them carefully. This wisdom is particularly apparent in the relationships between two interacting species. …”
Publicado 2018
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56669por Wang, Kang, Zhang, Xiang, Zheng, Ke, Yin, Xue-Dong, Xing, Lei, Zhang, Ai-Jie, Shi, Yang, Kong, Ling-Quan, Li, Fan, Ma, Bin-Lin, Li, Hui, Liu, Jin-Ping, Jiang, Jun, Ren, Guo-Sheng, Li, Hong-Yuan“…Nipple inversion, mammographic calcification, larger tumor size, medial tumor site, negative HER-2 status, and more positive ALNs are independent risk factors for IMLN metastasis, and the individualized nomogram is a feasible tool to predict the status of IMLN. …”
Publicado 2018
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56670por Subbiah, V, Velcheti, V, Tuch, B B, Ebata, K, Busaidy, N L, Cabanillas, M E, Wirth, L J, Stock, S, Smith, S, Lauriault, V, Corsi-Travali, S, Henry, D, Burkard, M, Hamor, R, Bouhana, K, Winski, S, Wallace, R D, Hartley, D, Rhodes, S, Reddy, M, Brandhuber, B J, Andrews, S, Rothenberg, S M, Drilon, A“…A second patient with KIF5B-RET fusion-positive lung cancer, acquired resistance to alectinib and symptomatic brain metastases experienced a dramatic response in the brain, and her symptoms resolved. CONCLUSIONS: These results provide proof-of-concept of the clinical actionability of RET alterations, and identify selective RET inhibition by LOXO-292 as a promising treatment in heavily pretreated, multikinase inhibitor-experienced patients with diverse RET-altered tumors.…”
Publicado 2018
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56671por Kawazoe, Tomoya, Yamamoto, Toshiyuki, Narita, Aya, Ohno, Kousaku, Adachi, Kaori, Nanba, Eiji, Noguchi, Atsuko, Takahashi, Tsutomu, Maekawa, Masamitsu, Eto, Yoshikatsu, Ogawa, Masafumi, Murata, Miho, Takahashi, Yuji“…In Case 2, a 28-year-old woman, the proband, who had marked splenomegaly in her childhood, survived well, contrary to the expected severe prognosis of infantile NPC. …”
Publicado 2018
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56672por Yamagishi, Toshinobu, Tanabe, Takahiro, Fujita, Hiroshi, Miyazaki, Kazuki, Yukawa, Takahiro, Sugiyama, Kazuhiro, Hamabe, Yuichi“…The only abnormal laboratory result at admission was anemia. Her hemodynamic status stabilized after red blood cell transfusion, and venoarterial extracorporeal membrane oxygenation was subsequently terminated. …”
Publicado 2018
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56673“…BACKGROUND: Conventional parameters including Ki67, hormone receptor and Her2/neu status are used for risk stratification for breast cancer. …”
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56674por Wesson, Jennifer, Hamunime, Ndapewa, Viadro, Claire, Carlough, Martha, Katjiuanjo, Puumue, McQuide, Pamela, Kalimugogo, Pearl“…One-third (31%) of survey respondents reported witnessing or knowing of client mistreatment at their hospital, about half (49%) agreed that “sometimes you have to yell at a woman in labor,” and a third (30%) agreed that pinching or slapping a laboring woman can make her push harder. Nurses were much more likely to agree with these statements than medical officers. …”
Publicado 2018
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56675por Patel, Neeraj M., Talathi, Nakul S., Talwar, Divya, Fabricant, Peter D., Kocher, Mininder S., Ganley, Theodore J., Lawrence, J. Todd R.“…The surgeon’s fellowship training was significantly associated with his or her preferred surgical technique.…”
Publicado 2018
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56676Prognostic significance of p16 & p53 immunohistochemical expression in triple negative breast cancerpor Hashmi, Atif Ali, Naz, Samreen, Hashmi, Shumaila Kanwal, Hussain, Zubaida Fida, Irfan, Muhammad, Khan, Erum Yousuf, Faridi, Naveen, Khan, Amir, Edhi, Muhammad Muzzammil“…METHODS: Total 150 cases of triple negative breast cancers were selected from records of pathology department archives that underwent surgeries at Liaquat National hospital, Karachi from January 2008 till December 2013. ER, PR and Her2neu immunohistochemistry were re-performed to confirm triple negative status. p16 & p53 immunohistochemistry was performed on all cases and association with various clinicopathologic parameters was determined. …”
Publicado 2018
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56677por Bula, Agatha, Kopp, Dawn M, Maman, Suzanne, Chinula, Lameck, Tsidya, Mercy, Tang, Jennifer H“…These findings suggest the importance of counselling both the affected woman and her husband about the benefits of family planning use, even after a poor obstetric outcome, to jointly choose the method they feel comfortable to use and dispel any misconceptions. …”
Publicado 2018
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56678por Hinton, Jason, Cerra-Franco, Alberto, Shiue, Kevin, Shea, Lindsey, Aaron, Vasantha, Billows, Geoffrey, Al-Hader, Ahmad, Lautenschlaeger, Tim“…However, she did have radiographic evidence of superior vena cava stenosis caused by extrinsic compression from her large right hilar primary tumor. She was treated with definitive chemoradiation, receiving 60 Gy of external beam radiation therapy given concurrently with chemotherapy. …”
Publicado 2018
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56679por Corleto, Vito Domenico, Di Marino, Vincenza Patrizia, Galli, Gloria, Antonelli, Giulio, Coluccio, Chiara, Di Cerbo, Arcangelo, Uccini, Stefania, Annibale, Bruno“…CASE PRESENTATION: A 42-year-old outpatient woman without previous significant gastrointestinal diseases, was referred with dyspeptic symptoms, fatigue and mild diarrhea from 4 months. Her first investigations including immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (anti-tTG) and stool parasitological and cultural analysis were negative. …”
Publicado 2018
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56680“…A pregnant woman from an urban high-HIV prevalence setting would be expected to make 34% more ANC visits (counts) than her rural low-HIV prevalence counterparts (p < 0.05). …”
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