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57001por De Caluwé, Alex, Buisseret, Laurence, Poortmans, Philip, Van Gestel, Dirk, Salgado, Roberto, Sotiriou, Christos, Larsimont, Denis, Paesmans, Marianne, Craciun, Ligia, Stylianos, Drisis, Vandekerckhove, Christophe, Reyal, Fabien, Isabelle, Veys, Eiger, Daniel, Piccart, Martine, Romano, Emanuela, Ignatiadis, Michail“…Pathological complete response (pCR) rate, however, is lower for luminal B BC in comparison to the triple negative (TNBC) and HER2+ subtypes. The addition of immune checkpoint blockade (ICB) to NACT has the potential to increase pCR rate but is hampered by the lower immunogenicity of luminal B BC. …”
Publicado 2021
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57002por Al-Mansour, Lama S., AlRasheed, Abdulrahman A., AlEnezi, Khaled R., AlAli, Hamza M.“…Despite medical management for both childhood primary angiitis of the central nervous system and elevated intracranial pressure, her neurological status continued to deteriorate and the elevated intracranial pressure became refractory. …”
Publicado 2021
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57003por Shiferaw, Mestet Yibeltal, Awedew, Atalel Fentahun, T/Mariam, Tsegazeab Laeke, Aklilu, Abenezer Tirsit, Akililu, Yemisirach Bizuneh, Andualem, Aemiro Mazengia“…CASE PRESENTATION: This paper highlights a case of an 8 days old female black race Ethiopian neonate who was brought by her mother with the chief complaint of lower back and lower neck swelling since birth. …”
Publicado 2021
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57004“…Professionalisation theory is introduced by presenting five general structural features of professionalised medical practice: (i) the patient has a concern; (ii) the physician deals with the patient’s concern; (iii) s/he gives assistance without patronising; (iv) s/he regards the patient in a holistic manner without building up a private relationship; and (v) s/he applies her/his general expertise to the particularities of the individual case. …”
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57005por Morimoto, Keita, Kanzaki, Go, Niikura, Takahito, Koike, Kentaro, Matsuo, Nanae, Maruyama, Yukio, Tsuboi, Nobuo, Yokoo, Takashi“…Oral steroid treatment was closely related with the recovery of her renal function and disappearance of MPO-ANCA. …”
Publicado 2021
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57006por Goodwin, Pamela J, Dowling, Ryan J O, Ennis, Marguerite, Chen, Bingshu E, Parulekar, Wendy R, Shepherd, Lois E, Gelmon, Karen A, Whelan, Timothy J, Ligibel, Jennifer A, Hershman, Dawn L, Mayer, Ingrid A, Hobday, Timothy J, Rastogi, Priya, Rabaglio-Poretti, Manuela, Lemieux, Julie, Thompson, Alastair M, Rea, Daniel W, Stambolic, Vuk“…The majority of patients had T2/3, node-positive, hormone receptor–positive, HER2-negative breast cancer treated with (neo)adjuvant chemotherapy and hormone therapy. …”
Publicado 2021
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57007por Kamada, Teppei, Ohdaira, Hironori, Takahashi, Junji, Fuse, Yoshinobu, Kai, Wataru, Nakashima, Keigo, Nakaseko, Yuichi, Suzuki, Norihiko, Yoshida, Masashi, Usui, Takeo, Suzuki, Yutaka“…The patient’s postoperative course was uneventful. However, her dementia worsened (Hasegawa’s dementia scale: 5/30 points) after the first operation. …”
Publicado 2021
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57008por Taira, Naruto, Kashiwabara, Kosuke, Tsurutani, Junji, Kitada, Masahiro, Takahashi, Masato, Kato, Hiroaki, Kikawa, Yuichiro, Sakata, Eiko, Naito, Yoichi, Hasegawa, Yoshie, Saito, Tsuyoshi, Iwasa, Tsutomu, Takashima, Tsutomu, Aihara, Tomohiko, Mukai, Hirofumi, Hara, Fumikata“…METHODS: Patients with HER2-negative MBC were randomly assigned to three different doses of q3w nab-PTX (SD 260 mg/m(2) vs. …”
Publicado 2021
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57009por Niu, Limin, Lv, Huimin, Zhang, Mengwei, Zeng, Huiai, Wang, Lifeng, Cui, Shude, Liu, Zhenzhen, Yan, Min“…Cranial magnetic resonance imaging (MRI) screening can detect asymptomatic BM in MBC patients (particularly those with HER2−positive or triple-negative disease), offering these patients an opportunity to undergo systemic drug therapy, thereby prolonging their survival. …”
Publicado 2021
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57010“…Anti-GD2 BsAb and anti-HER2 BsAb built on IgG-[L]-scFv platform were tested against human cancer xenografts in BALB-Rag2(−/−)IL-2R-γc-KO (BRG) mice. …”
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57011por Kirchner, M., Kluck, K., Brandt, R., Volckmar, A.-L., Penzel, R., Kazdal, D., Endris, V., Neumann, O., Seker-Cin, H., Goldschmid, H., Glade, J., Allgäuer, M., Kriegsmann, M., Winter, H., Muley, T., Perner, S., Frost, N., Reck, M., Fröhling, S., Schirmacher, P., Thomas, M., Budczies, J., Christopoulos, P., Stenzinger, A.“…However, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 gene (HER2, also known as ERBB2) exon 20 insertions (Ex20mut) are characterized by a poor response to currently approved tyrosine kinase inhibitors and immunotherapies. …”
Publicado 2021
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57012por Bortolini Silveira, Amanda, Bidard, François-Clément, Tanguy, Marie-Laure, Girard, Elodie, Trédan, Olivier, Dubot, Coraline, Jacot, William, Goncalves, Anthony, Debled, Marc, Levy, Christelle, Ferrero, Jean-Marc, Jouannaud, Christelle, Rios, Maria, Mouret-Reynier, Marie-Ange, Dalenc, Florence, Hego, Caroline, Rampanou, Aurore, Albaud, Benoit, Baulande, Sylvain, Berger, Frédérique, Lemonnier, Jérôme, Renault, Shufang, Desmoulins, Isabelle, Proudhon, Charlotte, Pierga, Jean-Yves“…Their combined value as prognostic and early monitoring markers was assessed in 198 HER2-negative metastatic breast cancer patients. …”
Publicado 2021
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57013“…MRI at 4 months after presentation revealed a partial reduction in lesions but enlarged areas in the left cerebellum and right parietal white matter and a new lesion in the region of the right ependyma with linear enhancement. Her CSF was positive for anti-myelin oligodendrocyte glycoprotein (MOG) and anti-glial fibrillary acidic protein (GFAP) antibodies using a transfected cell-based assay. …”
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57014“…This, along with previous studies, has led to concern over possible increased risk of mother‐to‐child (vertical) transmission, due to the initial high viral load in the first months after seroconversion, in a time when the woman and health services may be unaware of her status. This study looks at whether behavioural differences during the pregnant/postpartum period could reduce the impact of elevated risk of HIV acquisition per‐condomless‐coital‐act at the population level. …”
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57015por Ando, Kazuo, Hédou, Julien J., Feyaerts, Dorien, Han, Xiaoyuan, Ganio, Edward A., Tsai, Eileen S., Peterson, Laura S., Verdonk, Franck, Tsai, Amy S., Marić, Ivana, Wong, Ronald J., Angst, Martin S., Aghaeepour, Nima, Stevenson, David K., Blumenfeld, Yair J., Sultan, Pervez, Carvalho, Brendan, Stelzer, Ina A., Gaudillière, Brice“…Moreover, prolonged labor is associated with severe complications for the mother and her offspring, most importantly chorioamnionitis, uterine atony, and postpartum hemorrhage. …”
Publicado 2021
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57016“…Largely the use of an SOA within the farrowing house did not impact the sow or her piglets in either the intensive study or commercial validation study. …”
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57017“…RESULTS: The presence of circumscribed margins, posterior enhancement, and large size is correlated with triple-negative BC (TNBC), while high-risk microcalcifications and microlobulated margins is predictive of HER2-enriched cancers. Ductal carcinoma in situ is characterized by small size on ultrasound, absence of posterior acoustic features, and architectural distortion on mammogram, while luminal subtypes tend to be small, with spiculated margins and posterior acoustic shadowing (Luminal A type). …”
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57018“…Moreover, app use decreased the noncompliance rate for adjuvant chemotherapy (OR 0.41, 95% CI 0.27-0.65; P<.001) and radiotherapy (OR 0.49, 95% CI 0.25-0.96; P=.04), but not for anti-HER2 therapy (P=.76) or endocrine therapy (P=.39). …”
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57019por Kassu, Rodas Asrat, Mulatu, Hailu Abera, Gizaw, Sisay, Fisseha, Henok, Musema, Amir, Keder, Ayube, Negash, Semere, Tefera, Fithanegest, Lissanwerk, Adugna, Tamrat, Lemlem“…She had bilateral oculomotor nerve palsy. Her past medical history showed systemic hypertension for 18 years and dyslipidemia for 1 year. …”
Publicado 2021
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57020por Catenacci, Daniel V., Chao, Joseph, Muro, Kei, Al‐Batran, Salah Eddin, Klempner, Samuel J., Wainberg, Zev A., Shah, Manish A., Rha, Sun Young, Ohtsu, Atsushi, Liepa, Astra M., Knoderer, Holly, Chatterjee, Anindya, Van Cutsem, Eric“…Currently, the only published report of positive outcomes using biologics in 1L describes adding trastuzumab in HER2‐overexpressing advanced G/GEA. In 2L, doublet chemotherapy regimens are not uniformly more efficacious than single‐agent taxanes or irinotecan, and ramucirumab has demonstrated improved outcomes both as monotherapy and in combination. …”
Publicado 2021
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