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57341por Yoshida, T, Ozawa, Y, Kimura, T, Sato, Y, Kuznetsov, G, Xu, S, Uesugi, M, Agoulnik, S, Taylor, N, Funahashi, Y, Matsui, J“…METHODS: Triple negative breast cancer (TNBC) cells, which are oestrogen receptor (ER−)/progesterone receptor (PR−)/human epithelial growth receptor 2 (HER2−) and have a mesenchymal phenotype, were treated with eribulin for 7 days, followed by measurement of EMT-related gene and protein expression changes in the surviving cells by quantitative real-time PCR (qPCR) and immunoblot, respectively. …”
Publicado 2014
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57342“…Patients with high TSP were old age (P=0.035), had more Her-2-positive tumours (P=0.029), low-grade tumour inflammatory infiltrate (P=0.034), low CD68+macrophage infiltrate (P<0.001), low CD4+ (P=0.023) and low CD8+ T-lymphocytes infiltrate (P=0.017), tumour recurrence (P=0.015) and shorter cancer-specific survival (P<0.001). …”
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57343por Shapiro, Daniel B., Pappadakis, Jennifer A., Ellsworth, Nancy M., Hait, Howard I., Nagy, Zsolt Peter“…N.E. has received payment from Actavis, Inc., for her time for data collection. H.H. has received payment from Actavis, Inc., for statistical analyses. …”
Publicado 2014
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57344por Ashburn, Ann, Roberts, Lisa, Pickering, Ruth, Roberts, Helen Clare, Wiles, Rose, Kunkel, Dorit, Hulbert, Sophia, Robison, Judy, Fitton, Carolyn“…Each participant in the experimental group will dance with his or her spouse, a friend, or a partner from a bank of volunteers. …”
Publicado 2014
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57345“…INTRODUCTION: As providing health education, optimizing nutrition, and managing risk factors can be effective for ensuring a healthy outcome for women and her yet un-conceived baby, external influences play a significant role as well. …”
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57346por Smith, Laurie W, Khurshed, Fareeza, van Niekerk, Dirk J, Krajden, Mel, Greene, Sandra B, Hobbs, Suzanne, Coldman, Andrew J, Franco, Eduardo L, Ogilvie, Gina S“…CONCLUSIONS: The primary predictor of a woman’s intention to HPV self-collect for cervical cancer screening was her attitude towards the procedure. From a program planning perspective, these results indicate that education and awareness may be significant contributing factors to improving acceptance of self-collection and subsequently, improving screening attendance rates. …”
Publicado 2014
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57347por Fu, Xiaoyong, Creighton, Chad J, Biswal, Nrusingh C, Kumar, Vijetha, Shea, Martin, Herrera, Sabrina, Contreras, Alejandro, Gutierrez, Carolina, Wang, Tao, Nanda, Sarmistha, Giuliano, Mario, Morrison, Gladys, Nardone, Agostina, Karlin, Kristen L, Westbrook, Thomas F, Heiser, Laura M, Anur, Pavana, Spellman, Paul, Guichard, Sylvie M, Smith, Paul D, Davies, Barry R, Klinowska, Teresa, Lee, Adrian V, Mills, Gordon B, Rimawi, Mothaffar F, Hilsenbeck, Susan G, Gray, Joe W, Joshi, Amit, Osborne, C Kent, Schiff, Rachel“…METHODS: Altered cellular signaling, gene expression, and endocrine sensitivity were determined in inducible PTEN-knockdown ER-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer cell and/or xenograft models. …”
Publicado 2014
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57348por Wali, Vikram B, Gilmore-Hebert, Maureen, Mamillapalli, Ramanaiah, Haskins, Jonathan W, Kurppa, Kari J, Elenius, Klaus, Booth, Carmen J, Stern, David F“…INTRODUCTION: Human Epidermal Growth Factor Receptor (ERBB4/HER4) belongs to the Epidermal Growth Factor receptor/ERBB family of receptor tyrosine kinases. …”
Publicado 2014
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57349“…Membranous IGF-1R positivity in Her-2-positive or ER (estrogen receptor)-negative breast cancer was not found to be a significant prognostic indicator. …”
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57350por Tanaka, Mizuko, Ichikawa-Tomikawa, Naoki, Shishito, Namiko, Nishiura, Keisuke, Miura, Tomiko, Hozumi, Ayumi, Chiba, Hideki, Yoshida, Sayaka, Ohtake, Tohru, Sugino, Takashi“…Higher expression levels of these proteins were significantly associated with a younger age (<60 years), ER-negative status, HER2-positive status and a poorer prognosis. Co-expression of the two proteins showed more aggressive features with poorer prognosis. …”
Publicado 2015
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57351por Kwan, Marilyn L, Kroenke, Candyce H, Sweeney, Carol, Bernard, Philip S, Weltzien, Erin K, Castillo, Adrienne, Factor, Rachel E, Maxfield, Kaylynn S, Stijleman, Inge J, Kushi, Lawrence H, Quesenberry, Charles P, Habel, Laurel A, Caan, Bette J“…The PAM50 qRT-PCR assay was used to: a) assess tumor gene expression levels for ESR1, PGR, ERBB2, and 10 proliferation genes and b) classify tumors into intrinsic subtype (Luminal A, Luminal B, Basal-like, HER2-enriched, Normal-like). Body mass index (BMI) around BC diagnosis (kg/m(2)) was categorized as: underweight (<18.5), normal (18.5-24), overweight (25–29), mildly obese (30–34), and highly obese (≥35). …”
Publicado 2015
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57352por Savukaitytė, Aistė, Ugenskienė, Rasa, Jankauskaitė, Roberta, Čereškevičius, Darius, Šepetauskienė, Eglė, Juozaitytė, Elona“…Moreover, SULT1A1 G638A AA genotype significantly increased the chances of HER2 molecular subtype breast cancer when compared to GG genotype (OR = 19.971, 95% CI 1.716-232.480, P = 0.017). …”
Publicado 2015
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57353por Mastronardi, Claudio A., Whittle, Belinda, Tunningley, Robert, Neeman, Teresa, Paz-Filho, Gilberto“…After proper instruction, each participant punctured his/her own finger and collected capillary blood samples on pieces of a proprietary cellulose filter paper. …”
Publicado 2015
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57354por Onovo, Amobi Andrew, Nta, Iboro Ekpo, Onah, Aaron Anyebe, Okolo, Chukwuemeka Arinze, Aliyu, Ahmad, Dakum, Patrick, Atobatele, Akinyemi Olumuyiwa, Gado, Pamela“…BACKGROUND: Serodiscordance exists when the known HIV result of one member of a couple pair is positive while that of his/her partner is negative. In sub-Saharan Africa, in stable long-term couple partnerships (married or cohabiting), serodiscordance is a growing source of HIV-transmissions. …”
Publicado 2015
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57355por Lundgren, Ingela, van Limbeek, Evelien, Vehvilainen-Julkunen, Katri, Nilsson, Christina“…Third, a woman who has a previous CS has a similar need for support as other labouring women, but with some extra precautions and additional recommendations for her care. Finally, clinicians should help strengthen women’s trust in VBAC, including building their trust in giving birth vaginally, recognising that giving birth naturally is an empowering experience for women, alleviating fear and offering extra visits to discuss the previous CS, and joining with the woman in a dialogue while leaving the decision about the mode of birth open. …”
Publicado 2015
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57356por Maris, Pamela, Blomme, Arnaud, Palacios, Ana Perez, Costanza, Brunella, Bellahcène, Akeila, Bianchi, Elettra, Gofflot, Stephanie, Drion, Pierre, Trombino, Giovanna Elvi, Di Valentin, Emmanuel, Cusumano, Pino G., Maweja, Sylvie, Jerusalem, Guy, Delvenne, Philippe, Lifrange, Eric, Castronovo, Vincent, Turtoi, Andrei“…A retrospective IHC study performed on human breast carcinoma (n = 180) demonstrates that asporin expression is lowest in TNBC and HER2+ tumors, while HR+ tumors have significantly higher asporin expression (4-fold; p = 0.001). …”
Publicado 2015
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57357por Schubert, Christian, Haberkorn, Julia, Ocaña-Peinado, Francisco M., König, Paul, Sepp, Norbert, Schnapka-Köpf, Mirjam, Fuchs, Dietmar“…METHODS: The patient collected her entire urine for 56 days in 12 h-intervals to determine sTNF-R55/creatinine and protein/creatinine levels (ELISA, HPLC). …”
Publicado 2015
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57358por Wong, Ee Ming, Joo, JiHoon E., McLean, Catriona A., Baglietto, Laura, English, Dallas R., Severi, Gianluca, Hopper, John L., Milne, Roger L., FitzGerald, Liesel M., Giles, Graham G., Southey, Melissa C.“…Twenty probes in the BRCA1 promoter region showed increased methylation in triple-negative breast cancers compared to Luminal A, Luminal B and HER2-positive breast cancer subtypes. Validation of this observation in published data from The Cancer Genome Atlas (TCGA) Network (obtained from DNA extracted from fresh frozen tumour samples) confirms the quality of the data obtained from the improved protocol. …”
Publicado 2015
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57359por Papaxoinis, George, Kotoula, Vassiliki, Alexopoulou, Zoi, Kalogeras, Konstantine T., Zagouri, Flora, Timotheadou, Eleni, Gogas, Helen, Pentheroudakis, George, Christodoulou, Christos, Koutras, Angelos, Bafaloukos, Dimitrios, Aravantinos, Gerasimos, Papakostas, Pavlos, Charalambous, Elpida, Papadopoulou, Kyriaki, Varthalitis, Ioannis, Efstratiou, Ioannis, Zaramboukas, Thomas, Patsea, Helen, Scopa, Chrisoula D., Skondra, Maria, Kosmidis, Paris, Pectasides, Dimitrios, Fountzilas, George“…Tumors were subtyped with immunohistochemistry (IHC) and FISH for ER, PgR, Ki67, HER2 and androgen receptor (AR). PIK3CA mutations were analyzed by Sanger sequencing (exon 20) and qPCR (exon 9) (Sanger/qPCR mutations). …”
Publicado 2015
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57360por Nakanjako, Damalie, Namagala, Elizabeth, Semeere, Aggrey, Kigozi, Joanitor, Sempa, Joseph, Ddamulira, John Bosco, Katamba, Achilles, Biraro, Sam, Naikoba, Sarah, Mashalla, Yohana, Farquhar, Carey, Sewankambo, Nelson“…In Uganda, the Afya Bora Global Health Leadership Fellowship is implemented through the Makerere University College of Health Sciences (MakCHS) and her partner institutions. Lessons learned from the program, presented in this paper, may guide development of in-service training opportunities to enhance leadership skills of health workers in resource-limited settings. …”
Publicado 2015
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