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57741por Chen, Yan, Jiang, Bo, He, Yuange, Zhang, Chu, Zhou, Wenjie, Fang, Cheng, Gu, Dejian, Zhang, Minxia, Ji, Mei, Shi, Juntao, Yang, Xin“…These changes are mutually exclusive with molecular drivers such as EGFR, KRAS, HER-2, BRAF, ALK and ROS1. The prevalence rate of coexisting MET exon 14 mutations and EGFR sensitive mutations (L858R, exon 19 deletions) in Chinese population was reported to be 0.2% (3/1590). …”
Publicado 2022
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57742“…For each patient and his/her closest accompanying immediate family member (CAIFM) (spouse or son/daughter), two semi-structured conversations were held by using CT films (1st conversation) and 3D-IPM combined with 3D-IDM demonstration (2nd one) respectively. …”
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57743“…At 16 days post-vaccine, further imaging showed bilateral adrenal haemorrhage, non-occlusive splenic vein thrombosis and right ventricular thrombosis. Her cortisol level was <25 nmol/L. She was treated with anticoagulation, plasmapheresis, immunosuppression and steroid replacement. …”
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57744por van der Plas, Annicka G. M., Schellekens, Julia E. A. P., Glaudemans, Jolien J., Onwuteaka-Philipsen, Bregje D.“…We aimed to examine the association between having an ACP conversation and the patient feeling the GP knows him or her and the patient trusting the GP and vice versa. …”
Publicado 2022
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57745por Jeong, Soyeon, Farag, Ahmed K., Yun, Hye Kyeong, Jeong, Yoon A., Kim, Dae Yeong, Jo, Min Jee, Park, Seong Hye, Kim, Bo Ram, Kim, Jung Lim, Kim, Bu Gyeom, Lee, Dae-Hee, Roh, Eun Joo, Oh, Sang Cheul“…SIMPLE SUMMARY: AF8c, a lapatinib hybrid quinazoline-based EGFR/HER2 inhibitor, was chosen to scrutinize its antiproliferative activity in colorectal cancer (CRC) cells. …”
Publicado 2022
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57746por Plazas, J. Gallego, Arias-Martinez, A., Lecumberri, A., Martínez de Castro, E., Custodio, A., Cano, J.M., Hernandez, R., Montes, A.F., Macias, I., Pieras-Lopez, A., Diez, M., Visa, L., Tocino, R.V., Lago, N. Martínez, Limón, M.L., Gil, M., Pimentel, P., Mangas, M., Granja, M., Carnicero, A.M., Pérez, C. Hernández, Gonzalez, L.G., Jimenez-Fonseca, P., Carmona-Bayonas, A.“…Tumors in females were more frequently HER2-negative (67.8% versus 60.8%; P < 0.0001), grade 3 (45.4% versus 36.8%; P < 0.001), diffuse (43.3% versus 26.5%; P < 0.0001), and signet ring cell histology (40.5 versus 23.9%; P < 0.0001). …”
Publicado 2022
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57747por Díaz-Balboa, Estíbaliz, González-Salvado, Violeta, Rodríguez-Romero, Beatriz, Martínez-Monzonís, Amparo, Pedreira-Pérez, Milagros, Cuesta-Vargas, Antonio I., López-López, Rafael, González-Juanatey, José R., Pena-Gil, Carlos“…METHODS: This cross-sectional study uses data from the ONCORE randomized controlled trial, including 120 women aged 18–70 years with early-stage breast cancer under treatment with anthracycline and/or anti-HER2 antibodies. Participant characteristics were collected at baseline and pooled data from functional assessment (30STS test, relative and absolute VO2peak, and 6MWD) were collected at baseline and post-intervention (comprehensive cardio-oncology rehabilitation program vs. usual care). …”
Publicado 2022
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57748por Alsirafy, Samy A., Hassan, Amneh D., Sroor, Mahmoud Y., Samy, Ismail, Mousa, Somaia M. A.“…METHODS: The Scopus database was used to search 21 PC journals (1991–2020) for articles with at least one EMR-affiliated author independently of his/her position in the article. As an indicator, the 3-year average articles per million population per year (AAMY) was calculated. …”
Publicado 2022
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57749por Zhang, Wei-tong, Zhu, Gui-lu, Xu, Wu-qin, Zhang, Wei, Wang, Hui-zhen, Wang, Ya-bing, Li, Yong-xiang“…EBV infection was correlated with the mass size, menopausal status, axillary lymph node metastasis, vascular invasion, Ki-67 index, clinical stage, and estrogen receptor and progesterone receptor expressions (all P < 0.05), but not with the histological type, invasive ductal carcinoma histological grade, or human epidermal growth factor receptor 2 (HER2) expression (all P > 0.05). The positive rate of PD-1/PD-L1 expression was higher in the EBV-positive group than in the EBV-negative group (P < 0.05). …”
Publicado 2022
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57750por Khanam, Rasheda, Islam, Shafiqul, Rahman, Sayedur, Ahmed, Salahuddin, Islam, Ashraful, Hasan, Tarik, Hasan, Emran, Chowdhury, Nabidul Haque, Roy, Arunangshu Dutta, Jaben, Iffat Ara, Nehal, Asim A, Yoshida, Sachiyo, Manu, Alexander A, Raqib, Rubhana, McCollum, Eric D, Shahidullah, Mohammod, Jehan, Fyezah, Sazawal, Sunil, Bahl, Rajiv, Baqui, Abdullah H“…In addition, the risk of infection among women was higher if she reported chewing tobacco (RR = 1.19,95% CI = 1.03-1.38) and if her husband had an occupation requiring him to work indoors (RR = 1.16, 95% CI = 1.02-1.32). …”
Publicado 2022
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57751por Baumann, Anne, Denninger, Andrew R., Domin, Marek, Demé, Bruno, Kirschner, Daniel A.“…To explore the usefulness of neutron diffraction in the structural analysis of myelin, we investigated the use of in vivo labeling by metabolically incorporating non-toxic levels of deuterium ((2)H; D) via drinking water into a pregnant dam (D-dam) and her developing embryos. All of the mice were sacrificed when the pups (D-pups) were 55 days old. …”
Publicado 2022
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57752por Wang, Xian, Wang, Xueyang, Zhang, Yanjun, Zhang, Dekang, Song, Zhou, Meng, Qingyu, Li, Yunjian, Wang, Chunxi“…Base on immunohistochemical recombinant Ki-67 protein (Ki-67), estrogen receptor (ER), human epidermal growth factor receptor-2 (HER-2) and progesterone receptor (PR) results, the tumors were divided into four types According to the results of the sentinel lymph node (SLN) biopsies, the patients were divided into SLN (+) and SLN (−) groups. 3-dimensional (3D) Slicer software was used to outline the region of interest (ROI), and AMni-Kinetics software was used for feature extraction. …”
Publicado 2022
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57753por Teeyapun, Nattaya, Luangdilok, Sutima, Pakvisal, Nussara, Sainamthip, Panot, Mingmalairak, Siyamol, Poovorawan, Nattaya, Sitthideatphaiboon, Piyada, Parinyanitikul, Napa, Sriuranpong, Virote, Namkanisorn, Teerayuth, Inthasuwan, Pratchaya, Angspatt, Pattama, Wongchanapat, Ploytuangporn, Bamrungnam, Akradach, Leeleakpai, Nutchanok, Uttha, Sutheera, Jaichum, Supaporn, Kongkaew, Peerawich, Suksanong, Chayanin, Veranitinun, Rattiya, Prasomphol, Ampai, Sartsuk, Chada, Patcharajutanon, Cheeraporn, Preaprang, Supreeya, Choengsamor, Hathairat, Phongwan, Rungthong, Preeyasaksa, Charoenpit, Phaibulvatanapong, Ekkamol, Suntronwong, Nungruthai, Yorsaeng, Ritthideach, Vichaiwattana, Preeyaporn, Wanlapakorn, Nasamon, Kerr, Stephen J., Poovorawan, Yong, Wanchaijiraboon, Passakorn, Tanasanvimon, Suebpong“…For different types of cancer treatments, chemotherapy agents, especially anthracyclines (GMR 0.004; 95%CI 0.002–0.008), paclitaxel (GMR 0.268; 95%CI 0.123–0.581), oxaliplatin (GMR 0.340; 95%CI 0.165–0.484), and immunotherapy (GMR 0.203; 95%CI 0.109–0.381) showed significantly lower antibody response. Anti-HER2, endocrine therapy and 5-fluouracil or gemcitabine, however, had less impact on the immune response. …”
Publicado 2022
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57754por Chorwe-Sungani, Genesis, Mwagomba, Modesta, Chirwa, Ellen, Jere, Diana, Chipps, Jennifer“…Antenatal depression can adversely affect the well-being of the pregnant woman and her foetus. Depression is rarely detected by midwives due to the unavailability of relevant screening instruments in Malawi. …”
Publicado 2022
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57755por O’Shaughnessy, Joyce, Brufsky, Adam, Rugo, Hope S., Tolaney, Sara M., Punie, Kevin, Sardesai, Sagar, Hamilton, Erika, Loirat, Delphine, Traina, Tiffany, Leon-Ferre, Roberto, Hurvitz, Sara A., Kalinsky, Kevin, Bardia, Aditya, Henry, Stephanie, Mayer, Ingrid, Zhu, Yanni, Phan, See, Cortés, Javier“…In the ASCENT study, SG improved survival versus single-agent treatment of physician’s choice (TPC) in pre-treated metastatic triple-negative breast cancer (mTNBC). Hormone/HER2 receptor changes are common, particularly at relapse/metastasis. …”
Publicado 2022
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57756Analysis of Rates of Brain Metastases and Association With Breast Cancer Subtypes in Ontario, Canadapor Wang, Xin Ye, Rosen, Michael N., Chehade, Rania, Sahgal, Arjun, Das, Sunit, Warner, Ellen, Saskin, Refik, Zhang, Bo, Soliman, Hany, Chan, Kelvin K. W., Jerzak, Katarzyna J.“…RESULTS: Among 3916 patients with MBC, 1215 (31.0%) had HR-positive/ERBB2 (formerly HER2)-negative cancer, 310 (7.9%) had ERBB2-positive/HR-positive cancer, 200 (5.1%) had ERBB2-positive/HR-negative cancer, 258 (6.6%) had TNBC, and the remaining 1933 patients (49.4%) had an unknown breast cancer subtype. …”
Publicado 2022
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57757por Jiang, Qi, Zeng, Xiangyu, Zhang, Chenggang, Yang, Ming, Fan, Jun, Mao, Gan, Shen, Qian, Yin, Yuping, Liu, Weizhen, Tao, Kaixiong, Zhang, Peng“…METHODS: LAGC patients with clinical TNM stages 2–3, Her2(−), and Eastern Cooperative Oncology Group, scores 0–2 are routinely scheduled with NACT. …”
Publicado 2022
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57758por Routh, Eric D., Van Swearingen, Amanda E. D., Sambade, Maria J., Vensko, Steven, McClure, Marni B., Woodcock, Mark G., Chai, Shengjie, Cuaboy, Luz A., Wheless, Amy, Garrett, Amy, Carey, Lisa A., Hoyle, Alan P., Parker, Joel S., Vincent, Benjamin G., Anders, Carey K.“…BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive variant of breast cancer that lacks the expression of estrogen and progesterone receptors (ER and PR) and HER2. Nearly 50% of patients with advanced TNBC will develop brain metastases (BrM), commonly with progressive extracranial disease. …”
Publicado 2022
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57759por Zhu, Meng, Pi, Yong, Jiang, Zekun, Wu, Yanyan, Bu, Hong, Bao, Ji, Chen, Yujuan, Zhao, Lijun, Peng, Yulan“…RESULTS: The characteristics of high nuclear grade (P<0.001), necrosis (P=0.006), estrogen receptor negative (ER(−); P=0.003), progesterone receptor negative (PR(−); P=0.001), human epidermal growth factor receptor 2 positive (HER2+; P=0.034), lymphatic metastasis (P=0.008), and calcification (P<0.001) all showed significant correlations with MIC. …”
Publicado 2022
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57760por Minami, Christina A., Bryan, Ava F., Freedman, Rachel A., Revette, Anna C., Schonberg, Mara A., King, Tari A., Mittendorf, Elizabeth A.“…IMPORTANCE: Randomized clinical trial data have demonstrated that omission of surgical axillary evaluation does not affect overall survival in women 70 years and older with early-stage (clinical tumor category 1 [cT1] with node-negative [N0] disease) hormone receptor (HR)–positive and erb-B2 receptor tyrosine kinase 2 (ERBB2; formerly HER2)–negative breast cancer. Therefore, the Choosing Wisely initiative has recommended against routine use of sentinel lymph node biopsy (SLNB) in this population; however, retrospective data have revealed that more than 80% of patients eligible for SLNB omission still undergo the procedure. …”
Publicado 2022
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