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6171por Miletić, Dragana, Kraljević, Marija, Sokolović, Emir, Soče, Majana, Milović-Kovačević, Marijana, Bobić, Simonida, Cerić, Timur, Pleština, Stjepko, Bešlija, Semir, Marijanović, Inga“…BACKGROUND: Therapeutic options for human epidermal growth factor 2 (HER2)-positive metastatic breast cancer (mBC) are developing rapidly. …”
Publicado 2023
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6172por Hyung, J., Lee, J.Y., Kim, J.E., Yoon, S., Yoo, C., Hong, Y.S., Jeong, J.H., Kim, T.W., Jeon, S., Jun, H.R., Jung, C.K., Jang, J.P., Kim, J., Chun, S.M., Ahn, J.H.“…BACKGROUND: Human epidermal growth factor receptor 2 (HER2) (ERBB2)-directed agents are standard treatments for patients with HER2-positive breast and gastric cancer. …”
Publicado 2023
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6173por Zhong, Zhaoyun, Ling, Lijun, Tao, Jing, Xu, Weiwei, Liu, Xiaoan, Qian, Chao, Wang, Siqi, Deng, Jing, Wang, Shui, Zhou, Wenbin, Pan, Hong“…MWA combined with endocrine may be a feasible treatment strategy for elderly patients with HR-positive and HER2-negative invasive breast cancer.…”
Publicado 2023
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6174por Huang, Liang, Chen, Sheng, Yang, Wentao, Xu, Binghe, Huang, Tao, Yang, Hongjian, Zheng, Hong, Wang, Yongsheng, Song, Erwei, Zhang, Jin, Cui, Shude, Pang, Da, Tang, Lili, Lei, Yutao, Geng, Cuizhi, Shao, Zhiming“…However, PEH regimen achieved higher pCR in luminal-B (HER2-poitive) subgroup (55.0% vs. 24.0%; p = 0.033), but not in ERBB2+ subgroup (42.9% vs. 57.1%; p = 0.355). …”
Publicado 2015
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6175por Wu, Natalie C., Wong, Wendy, Ho, Kenneth E., Chu, Victor C., Rizo, Annaliza, Davenport, Simon, Kelly, Devon, Makar, Rosemary, Jassem, Jacek, Duchnowska, Renata, Biernat, Wojciech, Radecka, Barbara, Fujita, Tomoyuki, Klein, Jonathan L., Stonecypher, Mark, Ohta, Shoichiro, Juhl, Hartmut, Weidler, Jodi M., Bates, Michael, Press, Michael F.“…PURPOSE: The methods (IHC/FISH) typically used to assess ER, PR, HER2, and Ki67 in FFPE specimens from breast cancer patients are difficult to set up, perform, and standardize for use in low and middle-income countries. …”
Publicado 2018
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6176por Jevrić, Marko, Matić, Ivana Z., Krivokuća, Ana, Đorđić Crnogorac, Marija, Besu, Irina, Damjanović, Ana, Branković-Magić, Mirjana, Milovanović, Zorka, Gavrilović, Dušica, Susnjar, Snezana, Kisić Tepavčević, Darija, Stanojković, Tatjana“…CONCLUSION: Our study indicates that uPA and PAI-1 tumor tissue levels and 4G/5G variants of PAI-1 gene might be of prognostic significance in early node-negative luminal HER2-negative breast cancer patients treated with adjuvant endocrine therapy.…”
Publicado 2019
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6177por Harbeck, Nadia, Franke, Fabio, Villanueva-Vazquez, Rafael, Lu, Yen-Shen, Tripathy, Debu, Chow, Louis, Babu, Govind K, Im, Young-Hyuck, Chandiwana, David, Gaur, Anil, Lanoue, Brad, Rodriguez-Lorenc, Karen, Bardia, Aditya“…BACKGROUND: This analysis evaluated patient-reported outcomes (PROs) to assess health-related quality of life (HRQoL) in the phase III MONALEESA-7 trial, which previously demonstrated improvements in progression-free survival (PFS) and overall survival (OS) with ribociclib (cyclin-dependent kinase 4/6 inhibitor) + endocrine therapy (ET) compared with placebo + ET in pre- and perimenopausal patients with hormone-receptor-positive, HER2-negative (HR+/HER2−) advanced breast cancer (ABC). …”
Publicado 2020
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6178por Luthuli, Silondile, Haskins, Lyn, Mapumulo, Sphindile, Rollins, Nigel, Horwood, ChristianeEnlace del recurso
Publicado 2020
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6179por Bertucci, Alexandre, Bertucci, François, Zemmour, Christophe, Lerebours, Florence, Pierga, Jean-Yves, Levy, Christelle, Dalenc, Florence, Grenier, Julien, Petit, Thierry, Berline, Marguerite, Gonçalves, Anthony“…Here, we describe the rationale and design of PELICAN-IPC 2015-016/Oncodistinct-003 trial, an open-label, randomized, non-comparative, phase II study assessing efficacy, and safety of pembrolizumab in combination with anthracycline-containing neoadjuvant chemotherapy in HER2-negative IBC. The trial is ongoing. The primary endpoint is the pCR rate (ypT0/Tis, ypN0) in overall population and the co-primary endpoint is safety profile during a run-in phase. …”
Publicado 2020
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6180por Koh, Su-Jin, Ohsumi, Shozo, Takahashi, Masato, Fukuma, Eisuke, Jung, Kyung Hae, Ishida, Takanori, Dai, Ming-Shen, Chang, Chuan-Hsun, Dalvi, Tapashi, Walker, Graham, Bennett, James, O’Shaughnessy, Joyce, Balmaña, Judith“…BACKGROUND: The multinational BREAKOUT study (NCT03078036) sought to determine the prevalence of germline BRCA1/2 (gBRCA1/2) and somatic BRCA1/2 (sBRCA1/2) mutations and mutations in other homologous recombination repair (HRR) genes in women with HER2-negative metastatic breast cancer (MBC) starting first-line chemotherapy. …”
Publicado 2021
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