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661
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662por Ellsworth, Rachel E, Ellsworth, Darrell L, Patney, Heather L, Deyarmin, Brenda, Love, Brad, Hooke, Jeffrey A, Shriver, Craig D“…The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can be influenced by other genetic changes. …”
Publicado 2008
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663por Kavanagh, Dara O, Chambers, Gillian, O' Grady, Liam, Barry, Kevin M, Waldron, Ronan P, Bennani, Fadel, Eustace, Paul W, Tobbia, Iqdam“…The HER-2 4B5 Ventana monoclonal antibody was used. …”
Publicado 2009
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664
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665
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666
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667por Tripathy, Debu“…Anti-HER2 monoclonal antibodies have led to significant improvements in survival for both advanced and early stage HER2+ breast cancer, while newer agents, including other antibodies and HER2 receptor tyrosine kinase inhibitors and signal transduction modulators, are also demonstrating clinical activity and represent further opportunities to improve curability and quality of life.…”
Publicado 2009
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668“…Human epidermal growth factor receptor 2 (HER2) is an important prognostic and predictive factor in breast cancer. …”
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669por Ignatiadis, Michail, Rothé, Françoise, Chaboteaux, Carole, Durbecq, Virginie, Rouas, Ghizlane, Criscitiello, Carmen, Metallo, Jessica, Kheddoumi, Naima, Singhal, Sandeep K., Michiels, Stefan, Veys, Isabelle, Rossari, José, Larsimont, Denis, Carly, Birgit, Pestrin, Marta, Bessi, Silvia, Buxant, Frédéric, Liebens, Fabienne, Piccart, Martine, Sotiriou, Christos“…In CTC-positive women with DCIS/LCIS or M0 BC, HER2-positive CTCs were more commonly detected in HER2-positive (5 of 5 women) than HER2-negative BC (5 of 12 women) (p = 0.03). …”
Publicado 2011
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670“…Pathologists regularly determined the number of HER2-positive cases (HER2 3+, HER2 2+/amplified or amplified) in their laboratory, and figures were continuously entered into a central website. …”
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671por Montemurro, Filippo, Rossi, Valentina, Nolè, Franco, Redana, Stefania, Donadio, Michela, Martinello, Rossella, Verri, Elena, Valabrega, Giorgio, Rocca, Maria Cossu, Jacomuzzi, Maria Elena, Viale, Giuseppe, Sapino, Anna, Aglietta, Massimo“…Because of excessive cardiotoxicity, their use in combination with trastuzumab has been discouraged in patients with human epidermal growth factor receptor (HER)-2(+) metastatic breast cancer. We sought to describe how this treatment paradigm influenced the use of anthracyclines in this patient setting. …”
Publicado 2010
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672“…The relationship between abnormal HER2 expression and cancer is important in cancer therapeutics. …”
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673
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674por Thomas, A, Hoopmann, M, Schöndorf, T, Neumann, R, Mallmann, P, Göhring, U-J, Kurbacher, CM, Eisberg, C, Tanasale, T, Warm, MEnlace del recurso
Publicado 2001
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675“…She was treated with dopamine agonists for 10 years and after cessation of therapy her prolactin levels remain normal. The nasopharyngeal mass remained unchanged over time and there were no signs of hypopituitarism. …”
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678“…Approximately 20%–25% of patients with breast cancer demonstrate amplification of the human epidermal receptor type 2 (HER2) gene, resulting in an overexpression of the HER2 receptor. …”
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679por Kalari, Krishna R., Necela, Brian M., Tang, Xiaojia, Thompson, Kevin J., Lau, Melissa, Eckel-Passow, Jeanette E., Kachergus, Jennifer M., Anderson, S. Keith, Sun, Zhifu, Baheti, Saurabh, Carr, Jennifer M., Baker, Tiffany R., Barman, Poulami, Radisky, Derek C., Joseph, Richard W., McLaughlin, Sarah A., Chai, High-seng, Camille, Stephan, Rossell, David, Asmann, Yan W., Thompson, E. Aubrey, Perez, Edith A.“…Our goal in these analyses was to use genomic features from a test set of primary breast tumors to build an integrated transcriptome landscape model that makes relevant hypothetical predictions about the biological and/or clinical behavior of HER2-positive breast cancer. We interrogated RNA-Seq data from benign breast lesions, ER+, triple negative, and HER2-positive tumors to identify 685 differentially expressed genes, 102 alternatively spliced genes, and 303 genes that expressed single nucleotide sequence variants (eSNVs) that were associated with the HER2-positive tumors in our survey panel. …”
Publicado 2013
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680por Kruszewski, Wiesław Janusz, Rzepko, Robert, Ciesielski, Maciej, Szefel, Jarosław, Zieliński, Jacek, Szajewski, Mariusz, Jasiński, Wojciech, Kawecki, Krzysztof, Wojtacki, Janusz“…Estimation of HER2 membranous expression is routinely used in breast and gastric cancers, as both a prognostic and a predictive factor. …”
Publicado 2010
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