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  1. 681
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    Immunohistochemical expression of vegf and her-2 proteins in osteosarcoma biopsies
  2. 682
    por Parikh, P. M.
    Publicado 2014
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    Counterpoint: Angelina's choice-or the choice of anyone else in her place
  3. 683
    “…Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies. …”
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    Clinical and molecular characterization of HER2 amplified-pancreatic cancer
  4. 684
    por Bertelsen, Vibeke, Stang, Espen
    Publicado 2014
    “…The EGFR- or ErbB-family of receptor tyrosine kinases consists of EGFR/ErbB1, ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream signaling are generally initiated upon ligand-induced receptor homo- or heterodimerization at the plasma membrane, and endocytosis and intracellular membrane transport are crucial for regulation of the signaling outcome. …”
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    The Mysterious Ways of ErbB2/HER2 Trafficking
  5. 685
    “…On routine management, she was found to have a positive serum b-HCG of 80.4 (0–5 mIU/mL) but the patient denied any sexual activity in her life. During her admission, U/S of the pelvis was noncontributory. …”
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    Her2+ and b-HCG Producing Undifferentiated Gastric Adenocarcinoma
  6. 686
    por Woldie, Mirkuzie
    Publicado 2014
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    The Death of the Mother and Her Child Keeps on Bothering Developing Nations
  7. 687
    “…This review will focus on the current state of crosstalk between the HER and Notch receptors and the effectiveness of current therapies targeting HER-driven cancers.…”
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    Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer
  8. 688
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    Erratum to: Dual HER2 blockade: preclinical and clinical data
  9. 689
    “…The substantial benefits achieved with anti-HER2 targeted therapies in patients with HER2-positive breast cancer have emphasised the need for accurate assessment of HER2 status. …”
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    Updated UK Recommendations for HER2 assessment in breast cancer
  10. 690
    “…Only 16.7 % of tissue HER2 (tHER2) positive patients had significantly elevated sHER2 levels in serum. …”
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    Monitoring serum HER2 levels in breast cancer patients
  11. 691
    “…The majority of breast cancers present with estrogen receptor (ER)-positive and human epidermal growth factor receptor (HER2)-negative features and might benefit from endocrine therapy. …”
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    Targeted therapies for ER+/HER2- metastatic breast cancer
  12. 692
    “…Recent efforts towards molecular characterization have identified a subset of biliary patients that have HER2/neu amplification or mutation. HER2/neu amplification is associated with response to HER2/neu-directed therapy in breast and gastric cancers. …”
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    HER2/neu-directed therapy for biliary tract cancer
  13. 693
    “…Misdiagnosis in the evaluation of HER2 status in breast cancer may have consequent negative impact on clinical decision-making. …”
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    HER2 Status Determination: Analyzing the Problems to Find the Solutions
  14. 694
    “…In this article, we will review studies with information on prognosis and benefit of adjuvant therapy for T1abN0 HER-2+ breast cancer.…”
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    Infracentimetric HER-2 positive breast tumours—review of the literature
  15. 695
    “…Furthermore, we propose HER2 inhibitor-based therapy for HER2-amplified cervical cancer refractory to conventional therapy.…”
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    HER2 as a novel therapeutic target for cervical cancer
  16. 696
    “…Published studies on the association between human epidermal factor receptor 3 (HER3) expression and overall survival (OS) in gastrointestinal cancers have yielded conflicting results. …”
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    HER3 over-expression and overall survival in gastrointestinal cancers
  17. 697
    “…Here, we report 2 cases of isolated splenic metastases from an adenocarcinoma of the gastroesophageal junction, both with long-term survival outcome and overexpression of Her2.…”
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    Isolated Splenic Metastases of Her2+++ Gastroesophageal Junction Adenocarcinoma
  18. 698
    “…So far, little is known about the effect on the exact underlying signal pathway and molecular mechanisms of HER-2-positive meningioma cells. The goal of the present study was to determine the effects of HER-2 gene and possible involvement of MAPK signal pathway in human malignant meningioma. …”
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    The role of MAPK signaling pathway in the Her-2-positive meningiomas
  19. 699
    “…Thereafter, she received trastuzumab-DM1 and her disease was well-controlled again. Appendicitis caused by breast cancer is very rare. …”
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    Appendicitis caused by the metastasis of HER2-positive breast cancer
  20. 700
    “…Over the past 20 years, the prognosis of HER2-positive breast cancer has been transformed by the development of anti-HER2 targeted therapies. …”
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    Twenty years of anti-HER2 therapy-associated cardiotoxicity
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