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701
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702“…Human epidermal growth factor receptor 2 (HER2 or ErbB2) can be overexpressed, amplified and/or mutated in malignant tumors, and is a candidate for therapeutic targeting. …”
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703por Nam, Ah-Rong, Kim, Ji-Won, Cha, Yongjun, Ha, Hyerim, Park, Ji Eun, Bang, Ju-Hee, Jin, Mei Hua, Lee, Kyung-Hun, Kim, Tae-Yong, Han, Sae-Won, Im, Seock-Ah, Kim, Tae-You, Oh, Do-Youn, Bang, Yung-Jue“…This study aimed to investigate the pre-clinical and clinical implication of HER2 as a therapeutic target in BTC. We established two novel HER2-amplified BTC cell lines, SNU-2670 and SNU-2773, from gallbladder cancer patients. …”
Publicado 2016
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704por Jørgensen, Jan Trøst, Nielsen, Karsten Bork, Kjærsgaard, Gitte, Jepsen, Anna, Mollerup, Jens“…Background: HER2 serves as an important therapeutic target in gastroesophageal cancer. …”
Publicado 2017
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705por Soo Park, Ji, Youn, Jong-Chan, Shim, Chi Young, Hong, Geu-Ru, Lee, Choong-Kun, Kim, Jee Hyung, Park, Hyung Soon, Heo, Su Jin, Beom, Seung Hoon, Kim, Hyo Song, Rha, Sun Young, Chung, Hyun Cheol, Kang, Seok-Min, Jung, Minkyu“…Trastuzumab-induced cardiotoxicity (TIC) is the primary adverse event that limits the use of trastuzumab in HER2-positive breast cancer patients. However, the incidence and risk factors of TIC in HER2-positive gastric cancer are not known. …”
Publicado 2017
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706por Li, Qin, Zhang, RuiXue, Yan, Han, Zhao, PengFei, Wu, Li, Wang, Hui, Li, Teng, Cao, Bangwei“…Human epidermal growth factor receptor 3 (HER3) is closely involved in tumor progression and is an important target of therapy. …”
Publicado 2017
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707por Zeune, Leonie, van Dalum, Guus, Decraene, Charles, Proudhon, Charlotte, Fehm, Tanja, Neubauer, Hans, Rack, Brigitte, Alunni-Fabbroni, Marianna, Terstappen, Leon W. M. M., van Gils, Stephan A., Brune, Christoph“…Automated assessment of HER-2 expression by ACCEPT on 4084 CTCs of 132 patients showed 8 (6.1%) patients with all CTCs expressing HER-2, 14 (10.6%) patients with no CTC expressing HER-2 and 110 (83.3%) patients with CTCs showing a varying HER-2 expression level. …”
Publicado 2017
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708por Vega-Rubín-de-Celis, Silvia, Zou, Zhongju, Fernández, Álvaro F., Ci, Bo, Kim, Min, Xiao, Guanghua, Xie, Yang, Levine, Beth“…Allelic loss of the autophagy gene, beclin 1/BECN1, increases the risk of patients developing aggressive, including human epidermal growth factor receptor 2 (HER2)-positive, breast cancers; however, it is not known whether autophagy induction may be beneficial in preventing HER2-positive breast tumor growth. …”
Publicado 2018
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710por Wang, Sheng-Lin, Zhong, Guang-Xian, Wang, Xin-Wen, Yu, Feng-Qiang, Weng, Dan-Feng, Wang, Xin-Xing, Lin, Jian-Hua“…Multivariate analysis demonstrated that the expression of EGFR, HER-3, HER-4, EGFR/HER-3, EGFR/HER-4 and HER-3/HER-4 was an independent predictor of poor PFS and OS time in osteosarcoma patients with stage I–IIB disease. …”
Publicado 2018
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711por Ognjenovic, Ljubomir, Trajkovski, Gjorgji, Gjoshev, Stojan, Shumkovski, Aleksandar, Dzambaz, Darko, Hadzi-Manchev, Dragan, Volcevski, Goce, Fildishevski, Igor, Nikolova, Dafina, Petrushevska, Gordana, Janevska, Vesna, Janevski, Vlado“…AIM: To determine the expression of the HER2 protein in gastric carcinoma and to correlate the expression of a HER2 protein with clinicopathological characteristics of the disease. …”
Publicado 2018
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712“…Although the prognosis and prediction of therapeutic benefit for breast cancer patients overexpressing the human epidermal growth factor receptor 2 (HER2) have dramatically changed with the administration of anti-HER2-targeted therapies, HER2-positive metastatic breast cancer is still an incurable disease. …”
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713“…Krim was first and foremost a scientist. We highlight her pioneering research in fetal sex determination, as well as her activism during the unfolding AIDS epidemic, which culminated in the cofounding of amfAR, the Foundation for AIDS Research. …”
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714por Alcalá-Corona, Sergio Antonio, Espinal-Enríquez, Jesús, de Anda-Jáuregui, Guillermo, Hernández-Lemus, Enrique“…HER2-enriched breast cancer is a complex disease characterized by the overexpression of the ERBB2 amplicon. …”
Publicado 2018
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715por Ciesielski, Maciej, Szajewski, Mariusz, Pęksa, Rafał, Lewandowska, Marzena Anna, Zieliński, Jacek, Walczak, Jakub, Szefel, Jarosław, Kruszewski, Wiesław Janusz“…In gastric cancer, HER2 protein overexpression is considered to be conducive to the higher proliferation activity of the tumor cells. …”
Publicado 2018
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716“…This case describes the use of novel DNA sequencing technology to provide a targeted treatment option, HER-2 inhibition, in a patient with HER-2 overexpressing ampullary adenocarcinoma. …”
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717por Liu, Peng, Tang, Hailin, Wu, Jiali, Kong, Yanan, Zhang, Lijuan, Xie, Xinhua, Xiao, Xiangsheng“…OBJECTIVE: To investigate the effect of linc01638 on tumorigenesis in HER2-positive breast cancer. METHODS: We first used qRT-PCR to detect linc01638 expression in HER2-positive breast cancer cells and tissues. …”
Publicado 2019
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718por Elmas, Sait, Macdonald, Thomas J., Skinner, William, Andersson, Mats, Nann, Thomas“…The copper metallopolymer was found to be highly active for the electrocatalytic hydrogen generation (HER) in an aqueous solution at pH 7.4 and overpotentials at 300 mV vs. reversible hydrogen electrode (RHE). …”
Publicado 2019
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719“…HER3 is the third member of the human epidermal growth factor receptor (HER/EGFR) family, and unlike its other family members, is unique due to its minimal intrinsic kinase activity. …”
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720“…Trastuzumab and pertuzumab are monoclonal antibodies that bind to distinct subdomains of the extracellular domain of human epidermal growth factor receptor 2 (HER2). Adding these monoclonal antibodies to the treatment regimen of HER2-positive breast cancer has changed the paradigm for treatment in that form of cancer. …”
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