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841
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842por Lynce, F., Barac, A., Geng, X., Dang, C., Yu, A. F., Smith, K. L., Gallagher, C., Pohlmann, P. R., Nunes, R., Herbolsheimer, P., Warren, R., Srichai, M. B., Hofmeyer, M., Cunningham, A., Timothee, P., Asch, F. M., Shajahan-Haq, A., Tan, M. T., Isaacs, C., Swain, S. M.“…PURPOSE: HER2-targeted therapies have substantially improved the outcome of patients with breast cancer, however, they can be associated with cardiac toxicity. …”
Publicado 2019
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843por Garcia-Flores, Alejandro E., Sollome, James J., Thavathiru, Elangovan, Bower, Joseph L., Vaillancourt, Richard R.“…Our study suggests that targeting downstream proteins in the HER2/HER3-induced extracellular lactate signaling pathway may be a way to inhibit the Warburg Effect to disrupt tumor growth.…”
Publicado 2019
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844por Ma, Jui-Wen, Hung, Chao-Ming, Lin, Ying-Chao, Ho, Chi-Tang, Kao, Jung-Yie, Way, Tzong-DerEnlace del recurso
Publicado 2019
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845por Zhao, Wei, Bian, Li, Wang, Tao, Zhang, Shaohua, Li, Jianbin, Xu, Fengrui, Jiang, Zefei“…And we further show the effectiveness of the two anti-HER2 therapy groups. METHODS: A total of 342 HER2-positive metastatic breast cancer (MBC) patients whose disease progressed during prior anti-HER2 (trastuzumab) and standard chemotherapy therapy from Department of Breast Oncology, the Fifth Medical Center of Chinese PLA General Hospital, from August 2010 to December 2016 were included. …”
Publicado 2020
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846por Bitencourt, Almir G.V., Gibbs, Peter, Rossi Saccarelli, Carolina, Daimiel, Isaac, Lo Gullo, Roberto, Fox, Michael J., Thakur, Sunitha, Pinker, Katja, Morris, Elizabeth A., Morrow, Monica, Jochelson, Maxine S.“…BACKGROUND: To use clinical and MRI radiomic features coupled with machine learning to assess HER2 expression level and predict pathologic response (pCR) in HER2 overexpressing breast cancer patients receiving neoadjuvant chemotherapy (NAC). …”
Publicado 2020
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847por Zhou, Yu, Yuan, Yuan, Li, Liuyi, Wang, Xueliang, Quan, Yimin, Liu, Chunyu, Yu, Mengchao, Hu, Xiuting, Meng, Xiangfeng, Zhou, Zhen, Zhang, Chen-Yu, Chen, Xi, Liu, Minghui, Wang, Chen“…HER2 amplification greatly contributes to the tumorigenesis of multiple cancers. …”
Publicado 2021
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848por Lee, Jangsoon, Liu, Huey, Pearson, Troy, Iwase, Toshiaki, Fuson, Jon, Lalani, Alshad S., Eli, Lisa D., Diala, Irmina, Tripathy, Debu, Lim, Bora, Ueno, Naoto T.“…Human epidermal growth factor receptor (EGFR) 2 (HER2) is overexpressed/amplified in about 25% of all breast cancers, and EGFR is overexpressed in up to 76% and amplified in up to 24% of triple-negative breast cancers (TNBC). …”
Publicado 2021
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849por Shen, Guoshuang, Zhao, Fuxing, Huo, Xingfa, Ren, Dengfeng, Du, Feng, Zheng, Fangchao, Zhao, Jiuda“…BACKGROUND: This meta-analysis aimed to better elucidate the predictive value of human epidermal growth factor receptor 2 (HER2)-enriched subtype of pathological complete response (pCR) rate within HER2-positive breast cancer patients receiving neoadjuvant treatment. …”
Publicado 2021
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850“…BACKGROUND: Studies have shown that neoadjuvant anti-HER-2 therapy and chemotherapy can increase pathologic complete response (pCR) rate in HER-2-positive breast cancer patients and improve prognosis. …”
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851“…Non-small-cell lung cancer (NSCLC) harbouring HER2 alterations is now considered a distinct molecular subtype. …”
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852por Sun, Ying, Chen, Beibei, Li, Jisheng, Peng, Ling, Li, Shuguang, Yu, Xuejun, Li, Li“…CONCLUSION: Pyrotinib is highly beneficial to HER2-positive metastatic breast cancer patients, even in patients with previous lapatinib exposure. …”
Publicado 2021
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853por Ni, Jing, Kabraji, Sheheryar, Xie, Shaozhen, Wang, Yanzhi, Pan, Peichen, He, Xiaofang, Liu, Zongming, Leone, Jose Palbo, Long, Henry W., Brown, Myles A., Winer, Eric P., Dillon, Deborah A. R., Lin, Nancy U., Zhao, Jean J.“…Approximately 50% of patients with metastatic HER2-positive (HER2+) breast cancer develop brain metastases (BCBMs). …”
Publicado 2022
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854por Ramamoorthi, Ganesan, Kodumudi, Krithika, Snyder, Colin, Grover, Payal, Zhang, Hongtao, Greene, Mark I, Basu, Amrita, Gallen, Corey, Wiener, Doris, Costa, Ricardo L B, Han, Hyo S, Koski, Gary, Czerniecki, Brian J“…BACKGROUND: Human epidermal growth factor receptor 2 (HER2) targeted antibodies in combination with chemotherapy has improved outcomes of HER2 positive (pos) breast cancer (BC) but toxicity of therapy remains a problem. …”
Publicado 2022
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855por Dunton, Kyle, Vondeling, Gerard, Hancock, Elizabeth, Petrou, Margaret, Burn, Oliver, Paine, Abby“…BACKGROUND: DESTINY-Breast01 (NCT03248492) is a phase II single-arm trial evaluating trastuzumab deruxtecan (T-DXd) in adults with human epidermal growth factor receptor 2-positive (HER2+) unresectable or metastatic breast cancer (u/mBC) who have received two or more prior anti-HER2 therapies. …”
Publicado 2022
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856por Huang, Jiayi, Chen, Xiao, Guo, Jinfeng, Song, Lin, Mu, Yanxi, Zhao, Han, Du, Caiwen“…Although human epidermal growth factor receptor 2 (HER2)-targeted therapy significantly improves the prognosis of patients with HER2-positive breast cancer, most patients with advanced breast cancer eventually progress due to drug resistance. …”
Publicado 2022
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857por Nitta, Hiroaki, Kelly, Brian D, Padilla, Mary, Wick, Nikolaus, Brunhoeber, Patrick, Bai, Isaac, Singh, Shalini, Ranger-Moore, Jim, Bieniarz, Chris, Tsuda, Hitoshi, Grogan, Thomas M“…BACKGROUND: The eligibility of breast cancer patients for human epidermal growth factor receptor 2 (HER2)-directed therapies is determined by the HER2 gene amplification and/or HER2 protein overexpression status of the breast tumor as determined by in situ hybridization (ISH) or immunohistochemistry (IHC), respectively. …”
Publicado 2012
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