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901por Canonici, Alexandra, Gijsen, Merel, Mullooly, Maeve, Bennett, Ruth, Bouguern, Noujoude, Pedersen, Kasper, O'Brien, Neil A, Roxanis, Ioannis, Li, Ji-Liang, Bridge, Esther, Finn, Richard, Slamon, Dennis, McGowan, Patricia, Duffy, Michael J., O'Donovan, Norma, Crown, John, Kong, Anthony“…Trastuzumab has been shown to improve the survival outcomes of HER2 positive breast cancer patients. However, a significant proportion of HER2-positive patients are either inherently resistant or develop resistance to trastuzumab. …”
Publicado 2013
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902“…We assessed the potential of digital PCR for highly accurate assessment of DNA concentration with EFTUD2 as chromosome 17 reference probe. We assessed a HER2:EFTDU2 ratio by digital PCR assay in the microdissected DNA from 18 HER2 amplified and 58 HER2 non-amplified cancers. …”
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903
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904“…Trastuzumab targets the human epidermal growth factor receptor 2 (HER2) receptor on breast cancer cells that express this tyrosine kinase receptor. …”
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905por Brufsky, Adam M“…Human epidermal growth factor receptor-2 (HER2) is overexpressed in up to 30% of breast cancers; HER2 overexpression is indicative of poor prognosis. …”
Publicado 2014
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906“…We also showed that p38 mitogen-activated protein kinase signaling was involved in leptin expression induced by HER2. We showed a crucial role of leptin in the invasiveness of HER2-MCF10A cells using an siRNA molecule targeting leptin. …”
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907por Babashahi, Mashaallah, Mehrazma, Mitra, Nasiri, Seyed Javad, Azizi Jalilian, Farid, Rezaei-Tavirani, Mostafa“…Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system. …”
Publicado 2013
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908por Yim-im, Wannarat, Sawatdichaikul, Orathai, Semsri, Suwanna, Horata, Natharinee, Mokmak, Wanwimon, Tongsima, Sissades, Suksamrarn, Apichart, Choowongkomon, Kiattawee“…HER2 has been used as a drug target for cancers. …”
Publicado 2014
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909“…The evolving field of HER2-targeted therapy has significantly improved the outcome of women diagnosed with HER2-positive invasive breast cancer. …”
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910por Kinugasa, H, Nouso, K, Tanaka, T, Miyahara, K, Morimoto, Y, Dohi, C, Matsubara, T, Okada, H, Yamamoto, K“…The concordance rate of FFPE with ctDNA was not high (62.5%); however, patients who were HER2-positive by ctDNA had significantly shorter survival compared with HER2-negative patients. …”
Publicado 2015
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911“…Breast cancer tumors that demonstrate gene amplification or overexpression of human epidermal growth factor receptor 2 (HER2) are classified as HER2-positive. They account for approximately 15% of all breast cancers and represent an adverse prognostic factor. …”
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912por Tschui, J., Vassella, E., Bandi, N., Baumgartner, U., Genitsch, V., Rotzer, D., Seiler, R., Thalmann, G. N., Fleischmann, A.“…Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy in urothelial bladder cancer (UBC). …”
Publicado 2015
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913“…BACKGROUND: Her2/neu is one of the epidermal growth factor receptors families and seems to have prognostic significance of some solid tumors. …”
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914“…Objectives. HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab. …”
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915por Rosestedt, Maria, Andersson, Ken G., Mitran, Bogdan, Tolmachev, Vladimir, Löfblom, John, Orlova, Anna, Ståhl, Stefan“…Human epidermal growth factor receptor 3 (HER3) is involved in the progression of various cancers and in resistance to therapies targeting the HER family. …”
Publicado 2015
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916por Spector, Neil L., Robertson, Faith C., Bacus, Sarah, Blackwell, Kimberly, Smith, Deborah A., Glenn, Kelli, Cartee, Leanne, Harris, Jennifer, Kimbrough, Carie L., Gittelman, Mark, Avisar, Eli, Beitsch, Peter, Koch, Kevin M.“…The relationship between tumor and plasma concentration was complex, indicating multiple determinants. HER receptor phosphorylation varied depending upon lapatinib tumor concentrations, suggestive of changes in the repertoire of HER homo- and heterodimers. …”
Publicado 2015
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917por Garau, RobertaEnlace del recurso
Publicado 2016
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918por Gijs, Marlies, Penner, Gregory, Blackler, Garth B., Impens, Nathalie R.E.N., Baatout, Sarah, Luxen, André, Aerts, An M.“…In addition, both aptamers were able to bind with high specificity to HER2-overexpressing cells and HER2-positive tumor tissue samples. …”
Publicado 2016
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919por Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.“…Breast cancers (BC) with HER2 overexpression (referred to as HER2 positive) progress more aggressively than those with normal expression. …”
Publicado 2016
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920“…The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affibody molecule ABY-025. …”
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