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981por Lu, Peipei, Foley, Joseph, Zhu, Chunfang, McNamara, Katherine, Sirinukunwattana, Korsuk, Vennam, Sujay, Varma, Sushama, Fehri, Hamid, Srivastava, Arunima, Zhu, Shirley, Rittscher, Jens, Mallick, Parag, Curtis, Christina, West, Robert“…Multiple subclones of HER2-amplified DCIS with distinct CNV profiles are observed, suggesting that multiple events occurred for the acquisition of HER2 amplification. …”
Publicado 2021
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982por De Giovanni, Carla, Landuzzi, Lorena, Palladini, Arianna, Nicoletti, Giordano, Nanni, Patrizia, Lollini, Pier-Luigi“…This review will focus on the role of receptor tyrosine kinases of the human epidermal growth factor receptor (EGFR) family that is comprised EGFR itself, HER2, HER3 and HER4 in RMS onset and the potential therapeutic targeting of receptor tyrosine kinases. …”
Publicado 2021
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983
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984por Mahmoudi, Reza, Dianat-Moghadam, Hassan, Poorebrahim, Mansour, Siapoush, Samaneh, Poortahmasebi, Vahdat, Salahlou, Reza, Rahmati, Mohammad“…These molecules have been considered as a targeted strategy in the treatment of human cancers. HER2 tumor biomarker is a transmembrane tyrosine kinase receptor that can be used for targeted therapies in the forms of anti-HER2 monoclonal antibodies, antibody–drug conjugates and immunotoxins. …”
Publicado 2021
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985por Huai, Jianguo, Cao, Ming, Jiang, Yan, Yang, Xiaomiao, Zhu, Yanyan, Si, Youyi, Xu, Man, Shen, Chenxiang, Han, Tao, Lian, Xiaochun“…Only 41.1% (65/158) of patients had histology and CTC HER2 status consistent with the remaining 58.9% (93/158) of patients, although their histological HER2 was positive, and CTC HER2 was negative. …”
Publicado 2021
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986
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987por Shagisultanova, Elena, Crump, Lyndsey S., Borakove, Michelle, Hall, Jessica K., Rasti, Aryana R., Harrison, Benjamin A., Kabos, Peter, Lyons, Traci R., Borges, Virginia F.“…Breast cancers that express hormonal receptors (HR) and HER2 display resistance to targeted therapy. Tumor-promotional signaling from the HER2 and estrogen receptor (ER) pathways converges at the cyclin D1 and cyclin-dependent kinases (CDK) 4 and 6 complex, which drives cell-cycle progression and development of therapeutic resistance. …”
Publicado 2022
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988por Díaz-Rodríguez, Elena, Gandullo-Sánchez, Lucía, Ocaña, Alberto, Pandiella, Atanasio“…SIMPLE SUMMARY: A proportion of breast tumors bear the oncogenic transmembrane tyrosine kinase protein HER2. Even though therapies that target HER2 have changed the prognosis and quality of life of patients with HER2+ breast tumors, resistance to those therapies is still an important clinical problem. …”
Publicado 2021
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989“…In 15%-30% of breast cancers, overexpression of the human epidermal growth factor receptor 2 (Her-2/neu) is associated with more aggressive tumor development. …”
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990“…A recent report showed that SOX11, an embryogenic mammary transcription factor, is overexpressed in breast cancer. HER2 is also dysregulated in breast cancer stem cells; however, the relative expression of these two genes in recurrent breast cancer has not been investigated. …”
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991por Bartsch, Rupert, Gampenrieder, Simon Peter, Rinnerthaler, Gabriel, Petru, Edgar, Egle, Daniel, Petzer, Andreas, Balic, Marija, Pluschnig, Ursula, Sliwa, Thamer, Singer, Christian“…A group of Austrian breast cancer specialists met in December 2020 to establish a comprehensive clinical benefit-risk profile of available HER2-targeted therapies based on recent data and to develop an updated treatment algorithm by consensus over several months in 2021. …”
Publicado 2022
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992“…However, molecular targeted therapy is mainly aimed at HER2-positive breast cancer and has not yet achieved satisfactory curative effect on HER2-negative breast cancer. …”
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993“…HER2-positive inflammatory breast cancer (IBC) is associated with poor overall survival. …”
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994por Chuang, Jeremy, Klempner, Samuel, Waters, Kevin, Atkins, Katelyn, Chao, Joseph, Cho, May, Hendifar, Andrew, Gangi, Alexandra, Burch, Miguel, Mehta, Pareen, Gong, Jun“…In this review, we discuss the current therapeutic landscape for HER2-positive gastroesphageal cancer and the seminal clinical trials that have shaped our approach to this disease entity. …”
Publicado 2022
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995
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996“…This review examines the evolution of the radionuclide diagnosis of HER2-positive breast cancer using various compounds as a targeting module in clinical practice: from full-length antibodies to a new group of small synthetic proteins called alternative scaffold proteins. …”
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997“…About 15–20% of all breast cancers (BCs) are defined human epidermal growth factor receptor 2 (HER2)-positive, based on the overexpression of HER2 protein and/or amplification of ERBB2 gene. …”
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998“…Trastuzumab is a monoclonal antibody used in the treatment of breast cancer in cases where the tumor overexpresses the HER2 receptor, a cell membrane receptor activated by the epidermal growth factor. …”
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999
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1000por Smiljanić, Milutin, Panić, Stefan, Bele, Marjan, Ruiz-Zepeda, Francisco, Pavko, Luka, Gašparič, Lea, Kokalj, Anton, Gaberšček, Miran, Hodnik, Nejc“…Both of these effects may result in enhanced HER activity.…”
Publicado 2022
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