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  1. 1141
    por Sorscher, Steven
    Publicado 2013
    “…Trastuzumab is a monoclonal antibody targeting HER-2. HER-2 overexpression has been described in gallbladder cancer and in cholangiocarcinoma. …”
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    Marked radiographic response of a HER-2-overexpressing biliary cancer to trastuzumab
  2. 1142
    “…Because the transmembrane domain of HER2 is considered to be responsible for the dimerization and subsequent activation of the HER family and downstream signaling pathways, we performed functional analyses of these HER2 mutants. …”
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    Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas
  3. 1143
    “…Near-infrared-emitting quantum dot antiHER2-antibody bioconjugates successfully localized HER2 receptors on SK-BR-3 cells. …”
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    Near-infrared quantum dots for HER2 localization and imaging of cancer cells
  4. 1144
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    ‘This year I will not put her to work’: the production/reproduction nexus in Burkina Faso
  5. 1145
    “…AIM OF THE STUDY: To investigate the differences and relevance, and to evaluate the clinical significance of fluorescence in situ hybridisation and immunohistochemistry (IHC) in detecting HER2 in gastric cancer tissues. MATERIAL AND METHODS: The expression of HER2 protein and the amplification of the HER2 gene in 118 gastric cancer tissues were detected by immunohistochemistry and fluorescence in situ hybridisation, respectively. …”
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    Comparison of HER2 status by fluorescence in situ hybridisation and immunohistochemistry in gastric cancer
  6. 1146
    “…The monoclonal antibody (mAb) trastuzumab has improved the outcomes of patients with HER2+ breast cancer. However, a large number of HER2+ tumors are not responsive to, or become resistant to, trastuzumab-based therapy, and thus more effective therapies targeting HER2 are needed. …”
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    Construction and evaluation of a novel humanized HER2-specific chimeric receptor
  7. 1147
    “…The aim of this study was to compare human epidermal growth factor 2 (HER2) status in primary colorectal cancer and paired liver or lung metastasis. …”
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    Comparison of HER2 expression between primary colorectal cancer and their corresponding metastases
  8. 1148
    “…Over-expression of the HER2/neu receptor occurs in 20 to 30 percent of breast tumors and is linked to poorer prognosis. …”
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    Interference-Free HER2 ECD as a Serum Biomarker in Breast Cancer
  9. 1149
    “…A significant percentage of SDCs overexpress Her2 and the use of targeted therapy with trastuzumab can be considered in these patients. …”
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    Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma
  10. 1150
    “…RESULTS HER-2/neu was positive in six cases of HD (50%), four LD (21%) and two ID (9%). …”
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    HER-2/neu and E-cadherin Expression and Microsatellite Instability in Gastric Dysplasia
  11. 1151
    “…Her2 overexpression and amplification can be found in a significant subset of esophageal adenocarcinomas. …”
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    Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus
  12. 1152
    “…BACKGROUND: The development of HER2-targeted therapies has dramatically improved clinical outcomes for patients with any stage of HER2-positive breast cancer. …”
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    Profiling and targeting HER2-positive breast cancer using trastuzumab emtansine
  13. 1153
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    TP53 mutations among molecular subtypes of HER2-positive tumors
  14. 1154
    por Verma, Sunil
    Publicado 2014
    “…In this podcast, we talk to Dr Sunil Verma about the evolution of HER2 as a therapeutic target in breast cancer, and about how targeted therapy has revolutionized breast cancer treatment. …”
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    Advances in treating HER2-positive breast cancer: an interview with Sunil Verma
  15. 1155
    “…HER2(+) breast cancer (BC) is a highly aggressive subtype, affecting ~20% of BC patients. …”
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    Targeting HER2(+) breast cancer: the TBK1/IKKε axis
  16. 1156
    “…Her2 immunohistochemistry (IHC) was performed in addition. …”
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    Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer
  17. 1157
    por Dennie, Trevor
    Publicado 2015
    “…This case report describes treatment of a patient with metastatic lacrimal gland carcinoma with lapatinib, an oral agent with activity against Her-2/neu amplified malignancies. In this case, Her-2 overexpression was confirmed by biopsy of a metastatic site. …”
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    Metastatic, Her-2 Amplified Lacrimal Gland Carcinoma with Response to Lapatinib Treatment
  18. 1158
    “…Comparing to SATB1 or HER2 single positive expression, SATB1/HER2 co-expression tended to have even worse prognosis. …”
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    Expression of SATB1 and HER2 in breast cancer and the correlations with clinicopathologic characteristics
  19. 1159
    “…The HER2/TOP2A locus is of great importance in breast cancer. …”
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    Allelic imbalance at the HER2/TOP2A locus in breast cancer
  20. 1160
    “…This study aimed to determine the molecular effects of the HER2 inhibitor lapatinib in patients with HER2 positive DCIS. …”
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    Molecular effects of lapatinib in patients with HER2 positive ductal carcinoma in situ
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