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  1. 1161
    “…BACKGROUND: Treatment for patients with breast cancer (BC) is guided by human epidermal growth factor receptor 2 (HER2) status. The patient’s HER2 status is assessed using US Food and Drug Administration-approved in vitro diagnostic (IVD) immunohistochemical (IHC) tests and laboratory-developed IVD tests. …”
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    Immunohistochemical expression of HER2 in breast cancer: socioeconomic impact of inaccurate tests
  2. 1162
    “…The use of FISH increased the detection of HER2-positive tumours. Schistosomal infestation did not affect HER2 expression in patients with transitional cell carcinoma. …”
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    The clinical significance of HER2 protein amplification/expression in urinary bladder lesion
  3. 1163
    “…Human epidermal growth factor receptor 2 (HER2/ERBB2) gene amplification is associated with benefit from taxane therapy in breast cancer yet high HER2 expression also correlates with poor survival in both breast and ovarian cancer. …”
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    PRP4K is a HER2-regulated modifier of taxane sensitivity
  4. 1164
    “…Background: Testing for HER2 amplification and/or overexpression is currently routine practice to guide Herceptin therapy in invasive breast cancer. …”
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    Validation of a Fully Automated HER2 Staining Kit in Breast Cancer
  5. 1165
    “…Background: HER2-overexpression promotes malignancy by modulating signalling molecules, which include PTPs/DSPs (protein tyrosine and dual-specificity phosphatases). …”
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    Expression Profile of Tyrosine Phosphatases in HER2 Breast Cancer Cells and Tumors
  6. 1166
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    Support to women who denounce experiences of violence based on her social network
  7. 1167
    “…However, some patients classified as ‘HER‐2‐positive’ would be still resistant to the anti‐HER‐2 therapy. …”
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    Analysis of different HER‐2 mutations in breast cancer progression and drug resistance
  8. 1168
    “…HerDing was built by integrating public databases and by applying a text-mining method. …”
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    HerDing: herb recommendation system to treat diseases using genes and chemicals
  9. 1169
    “…BACKGROUND: Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. …”
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    Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma
  10. 1170
    “…Strategies for successful primary treatment of HER2-positive breast cancer include use of the HER2 inhibitors trastuzumab or lapatinib in combination with standard chemotherapy. …”
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    Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer
  11. 1171
    por Budiarto, Bugi Ratno, Desriani
    Publicado 2016
    “…Recent findings support the correlation between (Ile)655(Val) SNP in the HER2 gene with breast cancer risk. Moreover, the (Ile)655(Val) HER2 gene polymorphism could be a predictive factor in a neoadjuvant therapy setting. …”
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    Detection of HER2 Gene Polymorphism in Breast Cancer: PCR Optimization Study
  12. 1172
    “…The human epidermal growth factor receptor 2 (HER2) is overexpressed in 20% of breast carcinomas. …”
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    Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine
  13. 1173
    “…Particularly one of the peptides, P51, has nanomolar affinity and high specificity for HER2 in ex vivo and in vivo tests. Moreover, doxorubicin (DOX)-loaded liposome nanoparticles were modified with peptide P51 or P25 and demonstrated to improve the targeted delivery against HER2 positive cells. …”
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    HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
  14. 1174
    “…HER2 is overexpressed in about 20% of breast cancers and contributes to poor prognosis. …”
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    Therapeutic siRNA for drug-resistant HER2-positive breast cancer
  15. 1175
    por Mann, K, Kullberg, M
    Publicado 2016
    “…Treatment of isogeneic MCF7 and MCF7/Her18 cell lines, differing only in number of Her2 receptors, with the complete gene delivery system results in a 30-fold greater expression of luciferase activity in the Her2-overexpressing MCF7/Her18 cells. …”
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    Trastuzumab-targeted gene delivery to Her2-overexpressing breast cancer cells
  16. 1176
    “…BACKGROUND: The heregulin-1ß/HER3-driven pathway is implicated in several epithelial malignancies and its blockade is currently undergoing clinical investigation. …”
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    Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin
  17. 1177
    por Fusco, Nicola, Bosari, Silvano
    Publicado 2016
    “…In this review we provide a comprehensive overview of the current state-of-knowledge of HER2 alterations in the most common tumors of the digestive system and discuss the operational implications of HER2 testing.…”
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    HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists
  18. 1178
    “…The heterodimeric receptor tyrosine kinase complex formed by HER2 and HER3 can act as an oncogenic driver and is also responsible for rescuing a large number of cancers from a diverse set of targeted therapies. …”
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    Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding
  19. 1179
    “…HER2 amplification in fPTCs was invariably associated with BRAF(V600E) mutation. …”
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    Genetic Heterogeneity of HER2 Amplification and Telomere Shortening in Papillary Thyroid Carcinoma
  20. 1180
    “…Although many breast and lung cancers overexpress human epidermal growth factor receptor-2 (HER-2), no methods currently exist for effective and early detection of HER-2-positive cancers. …”
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    Dendrimer antibody conjugate to target and image HER-2 overexpressing cancer cells
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