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  1. 1181
    “…HER-2 positive tumors are among the most aggressive subtypes of breast cancer and are frequently associated with metastasis and poor outcome. …”
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    Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer
  2. 1182
    “…The immunohistochemistry revealed that 4 patients (3,3%) were HER2-positive, 6 patients (4,9%) HER2-undetermined, and 111 patients (91,7%) HER2-negative. …”
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    Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma
  3. 1183
    “…The cAMP-responsive element-binding protein (CREB) is involved in the tumorigenicity of HER-2/neu-overexpressing murine and human tumor cells, but a link between the HER-2/neu-mediated CREB activation, its posttranslational modification and localization and changes in the cellular metabolism, due to an altered (tumor) microenvironment remains to be established. …”
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    Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization
  4. 1184
    “…Here we report that the lncRNA LINC00052 expression correlates positively with HER3/ErbB3 levels in breast cancer cells. Gene silencing of LINC00052 diminished both LINC00052 and HER3 expression and reduced cancer cell growth in vitro and in vivo. …”
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    HER3 and LINC00052 interplay promotes tumor growth in breast cancer
  5. 1185
    “…BACKGROUND: ERBB2 (HER2) is a driver gene identified in non-small cell lung cancer (NSCLC). …”
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    HER2 mutations in Chinese patients with non-small cell lung cancer
  6. 1186
    “…We developed a computational approach based on deep learning that automatically scores HER2, a biomarker that defines patient eligibility for anti-HER2 targeted therapies in breast cancer. …”
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    Relevance of deep learning to facilitate the diagnosis of HER2 status in breast cancer
  7. 1187
    “…Valid HER2 testing is essential for optimal therapy of patients with HER2-positive gastric cancer and the correct use of first-line chemotherapy. …”
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    HER2 testing in gastric cancer: results of a German expert meeting
  8. 1188
    “…We obtained spheroids of human breast adenocarcinoma SKBR-3 overexpressing the HER2 cancer marker. The toxicity of HER2-targeted immunotoxin 4D5scFv-PE40 against spheroids was shown to be several orders of magnitude lower compared to a monolayer cell culture. …”
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    Spheroids of HER2-Positive Breast Adenocarcinoma for Studying Anticancer Immunotoxins In Vitro
  9. 1189
    “…Applying HER2-CONNECT with connectivity cutoff values established for breast carcinoma resulted in 72.7% sensitivity and 100% specificity for the identification of HER2 positive gene amplified cases. …”
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    Digital Image Analysis of HER2 Immunostained Gastric and Gastroesophageal Junction Adenocarcinomas
  10. 1190
    “…OBJECTIVE: The purpose of the present study was to explore the correlation between the contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) characteristics of breast cancers and the expression of human epidermal growth factor receptor 2 (HER-2). METHODS: HER-2 expression levels in the tumor masses of 167 clearly diagnosed cases of breast cancer were measured and analyzed. …”
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    The correlation between HER-2 expression and the CEUS and ARFI characteristics of breast cancer
  11. 1191
    “…Background: Human epidermal growth factor receptor type 2 (HER2) is abundant in a wide variety of tumors and associated with the poor prognosis. …”
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    PET of HER2 Expression with a Novel (18)FAl Labeled Affibody
  12. 1192
    “…In 2011, a phase I/II study evaluated the combination of trastuzumab and everolimus (a mTOR inhibitor) for treatment of Her2-positive metastatic breast cancer (MBC) for patients who had progressed on trastuzumab-based therapy. …”
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    Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer
  13. 1193
    “…We have developed highly potent and selective HER2-targeted Pt(iv) prodrugs bearing anti-HER2/neu peptides that induce targeted necrosis as a novel strategy to circumvent apoptosis-resistance. …”
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    Induction of targeted necrosis with HER2-targeted platinum(iv) anticancer prodrugs
  14. 1194
    “…Additionally, MET and HER2 overexpression were found in patient tumors, PDXs, and PDX cells. …”
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    Precision medicine approaches to lung adenocarcinoma with concomitant MET and HER2 amplification
  15. 1195
    “…Positivity for EGFR and double positivity for EGFR and HER2 (EGFR+/HER2+/c-Met+ and EGFR+/HER2+/c-Met-) were significantly correlated with lymph node metastasis (P = 0.010 for single and P = 0.013 for double) and UICC stage (P = 0.021 for single and P = 0.007 for double). …”
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    Prognostic significance of the co-expression of EGFR and HER2 in adenocarcinoma of the uterine cervix
  16. 1196
    “…HER2 is an established therapeutic target in metastatic GC (mGC). …”
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    Characterizing Metastatic HER2-Positive Gastric Cancer at the CDH1 Haplotype
  17. 1197
    “…BACKGROUND: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers has been less studied, including endometrial cancer. …”
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    HER2 expression patterns in paired primary and metastatic endometrial cancer lesions
  18. 1198
    “…The cellular uptake of SPIONs-Cy-PEG-scFv was threefold higher than that for untargeted PEGylated iron oxide nanoparticles (SPIONs-Cy-PEG) and is correlated to the expression of HER2 on cells. In vivo, the decrease of MR signals in HER2+ xenograft tumor is about 30% at 24 h after the injection. …”
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    Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes
  19. 1199
    “…Broadening the administration of HER2 inhibitors across tumor types and genomic alterations could benefit to patients with refractory metastatic tumors. …”
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    Efficacy of histology-agnostic and molecularly-driven HER2 inhibitors for refractory cancers
  20. 1200
    “…In this paper, we have studied the fluorescence lifetime as a means to distinguish bound HER2 specific affibody probes to HER2 receptors. …”
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    Using in vivo fluorescence lifetime imaging to detect HER2-positive tumors
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