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  1. 1361
    por Kasten, Erich
    Publicado 2023
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    The Girl Who Wants to Get Rid of Her Left Leg—Body Identity Dysphoria
  2. 1362
    “…To exert a maximum therapeutic effect on cancerous cells, we have conjugated two different payloads to different amino acids, cysteines (cys) and lysines (lys), on trastuzumab, which is a humanised anti-HER2 monoclonal antibody. First, trastuzumab was conjugated with monomethyl auristatin E (MMAE), an antimitotic agent, through a cleavable linker (Val-Cit) to prepare ADC (Tmab-VcMMAE). …”
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    A Novel Dual-Payload ADC for the Treatment of HER2+ Breast and Colon Cancer
  3. 1363
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    Thrombopoietin Receptor Agonists for Thrombocytopenia Secondary to HER2-Targeted Antibody Drug Conjugates
  4. 1364
    “…PATIENTS AND METHODS: The significance of pretreatment (89)Zr-trastuzumab PET, plasma circulating tumor DNA (ctDNA) dynamics, and tumor HER2 expression and whole exome sequencing was evaluated to identify prognostic biomarkers and mechanisms of resistance in patients treated on-protocol with PTC. …”
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    Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
  5. 1365
    “…The HER2 status is essential for formulating effective treatment plans for breast cancer. …”
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    HAHNet: a convolutional neural network for HER2 status classification of breast cancer
  6. 1366
    “…Objective: There is not enough data in the literature regarding Her-2 overexpression in uterine carcinosarcomas or its association with the prognosis. …”
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    cERBB-2/Her-2 Neu Overexpression and Prognostic Significance in Uterine Carcinosarcoma
  7. 1367
    “…Methods: Retrospective study of medical records of patients with breast cancer Her 2+ submitted the therapy with trastuzumab in early and advanced stage of the disease. …”
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    Cardiovascular adverse effects associated with the use of anti-HER2 in breast cancer treatment
  8. 1368
    “…Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) is a highly aggressive subtype associated with poor prognosis. …”
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    Pyrotinib-based therapeutic approaches for HER2-positive breast cancer: the time is now
  9. 1369
    “…Together the present findings are consistent with the assertion that HER2 is a viable therapeutic target in UM. Lapatinib is active in primary and metastatic UM as a clinically approved HER2 inhibitor. …”
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    Lapatinib dysregulates HER2 signaling and impairs the viability of human uveal melanoma cells
  10. 1370
    “…BACKGROUND: In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. …”
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    Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer
  11. 1371
    “…Breast cancer is the leading cause of cancer death in women worldwide. Trastuzumab, the main HER2-targeted treatment, faces limitations due to potential cardiotoxicity. …”
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    Mild Cardiotoxicity and Continued Trastuzumab Treatment in the Context of HER2-Positive Breast Cancer
  12. 1372
    “…Interestingly, upon Her6 downregulation, Prox1a is precociously upregulated in the PRs, to promote PR differentiation; conversely, loss of Prox1a also induces a downregulation of Her6. …”
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    Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina
  13. 1373
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    Inglämnlagare: a tool for restructuring Swedish HER record site data for statistical analysis
  14. 1374
    “…INTRODUCTION: Metaplastic breast carcinoma (MBC) is a rare histologic subtype of breast carcinoma, which is usually negative for estrogen receptor, progesterone receptor, and HER2. HER2-positive MBC is therefore extremely rare. …”
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    HER2-Positive Metaplastic Breast Cancer with Resistance to Neoadjuvant Chemotherapy: Case Report
  15. 1375
    “…A model based on these nine sites and trained solely on data from a low HER2-expressing cell line a priori predicted migration and proliferation in a HER2-overexpressing cell line. …”
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    Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data
  16. 1376
    “…The prognostic impact of HER2 expression was analyzed. HER2 gene was overexpressed and amplified in 6.6% of analyzed tumors. …”
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    HER2 Status in Ovarian Carcinomas: A Multicenter GINECO Study of 320 Patients
  17. 1377
    “…BACKGROUND: Both obesity and over-expression of HER II are associated with poor prognosis of breast cancer. …”
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    Obesity and HER 2 overexpression: a common factor for poor prognosis of breast cancer
  18. 1378
    “…Overexpression of HER2 is associated with an adverse prognosis in breast cancer. …”
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    A positive role for PEA3 in HER2-mediated breast tumour progression
  19. 1379
    “…Specificity and sensitivity of BiotHER immunostaining with respect to HER-2 amplification were tested on 164 breast carcinoma samples. …”
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    A modified Trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer
  20. 1380
    “…HER2 gene amplification rates were 8% in both groups. …”
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    HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder
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