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  1. 1381
    “…HER-2/neu may play a role in prostate carcinogenesis. …”
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    Detection of HER-2/neu-positive circulating epithelial cells in prostate cancer patients
  2. 1382
    “…The percentage of expression of HER-2, ER and PR was 26, 59.4, and 52.3%, respectively. …”
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    Correlation of HER-2 over-expression with clinico-pathological parameters in Tunisian breast carcinoma
  3. 1383
    “…METHODS: Expression of ObR, HER2, phospo-HER2 was assessed by immonoblotting. …”
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    Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis
  4. 1384
    “…INTRODUCTION: HER2 overexpression, or rather HER2 gene amplification, is indicative for Herceptin therapy in both metastatic and pre-metastatic breast cancer patients. …”
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    Presence of HER4 associates with increased sensitivity to Herceptin™ in patients with metastatic breast cancer
  5. 1385
    “…The orphan receptor tyrosine kinase ErbB2 (HER2/Neu) transforms cells when overexpressed1, and is an important therapeutic target in human cancer2,3. …”
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    ErbB2/HER2/Neu resembles an autoinhibited invertebrate EGF receptor
  6. 1386
    “…To address this issue, we created a clone library of human mammary epithelial (HME) cells that expresses different levels of HER2 and HER3 receptors in combination with endogenous EGFR/HER1. …”
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    HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells
  7. 1387
    “…BACKGROUND: HER2/neu is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. …”
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    Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss
  8. 1388
    “…We provide molecular evidences highlighting the role of EGFR, HER3, and downstream signaling pathways common to MET and HER family in resistance to MET inhibitors. …”
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    Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
  9. 1389
    “…HER2/neu (HER2) and cyclin E are important prognostic indicators in breast cancer. …”
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    A Novel Interaction Between HER2/neu and Cyclin E in Breast Cancer
  10. 1390
    “…A significant association was found between TOPOIIα protein overexpression and TopoIIα gene amplification, chromosome 17 aneusomy, HER-2/neu gene amplification and HER-2 protein overexpression as well as between HER-2 protein and HER-2/neu gene, TopoIIα gene and aneusomy for chromosome17, and between the genes TOPOIIα and HER-2/neu. …”
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    TOPOIIα and HER-2/neu overexpression/amplification in Barrett’s oesophagus, dysplasia and adenocarcinoma
  11. 1391
    “…Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-positive patients with advanced gastric cancer in a large multicentric trial (ToGA study). …”
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    HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing
  12. 1392
    “…The brain metastases over-expressed one or more members of the HER family and in particular HER3 was significantly over-expressed relative to matched primary tumors. …”
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    HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
  13. 1393
    “…However, in human blood plasma, oxidized quercetin easily reacts with protein thiols, whereas oxidized monoHER does not react with plasma protein thiols. Our results indicate that this can be explained by the presence of ascorbate in plasma; ascorbate is able to reduce oxidized monoHER to the parent compound monoHER before oxidized monoHER can react with thiols. …”
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    An Essential Difference between the Flavonoids MonoHER and Quercetin in Their Interplay with the Endogenous Antioxidant Network
  14. 1394
    “…METHODOLOGY/PRINCIPAL FINDINGS: 148 PSCCs were microarrayed and immunostained for phosphorylated EGFR (pEGFR), HER2, HER3, HER4, phosphorylated Akt (pAkt), Akt1 and PTEN proteins. …”
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    Alternative HER/PTEN/Akt Pathway Activation in HPV Positive and Negative Penile Carcinomas
  15. 1395
    “…We are reporting a patient with macro prolactinoma who was treated successfully throughout her pregnancy with cabergoline. We achieved a very good control of prolactinoma without any significant alteration of dose and also without any adverse effects. …”
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    Management of prolactinoma with cabergoline treatment in a pregnant woman during her entire pregnancy
  16. 1396
    por Tsang, R Y, Finn, R S
    Publicado 2012
    “…The use of trastuzumab, a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) alteration present in 25 to 30% of breast cancers, has been associated with improved survival outcomes in both the adjuvant and metastatic settings. …”
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    Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer
  17. 1397
    “…BACKGROUND: The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. …”
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    Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer
  18. 1398
    por Wong, Andrea L. A., Lee, Soo-Chin
    Publicado 2012
    “…HER2-positive breast cancers have poorer prognosis and are prime candidates for molecular-targeted therapy because they are driven by the unique mechanism of HER2 oncogene addiction. …”
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    Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer
  19. 1399
    “…A functional linkage of the structurally unrelated receptors HER2 and CXCR4 has been suggested for breast cancer but has not been evaluated for esophageal carcinoma. …”
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    Involvement of CXCR4 Chemokine Receptor in Metastastic HER2-Positive Esophageal Cancer
  20. 1400
    “…These breast cancer stem-like cells (BCSCs) rely on HER2 signaling for self-renewal, suggesting that HER2-targeted therapy targets BCSCs even when the bulk of the tumor does not overexpress HER2. …”
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    Determining Duration of HER2-Targeted Therapy Using Stem Cell Extinction Models
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