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1401“…Human epidermal growth factor receptor 2 (HER2) is overexpressed in around 20–30% of breast cancer tumors. …”
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1402por Mojtahedi, Zahra, Erfani, Nasroolah, Malekzadeh, Mahyar, Haghshenas, Mohammad Reza, Ghaderi, Abbas, Samsami Dehaghani, Alamtaj“…BACKGROUND: The association between HER2 Ile655Val single nucleotide polymorphism and cancer is controversial. …”
Publicado 2013
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1404“…Dual HER2 blockade has been the next step and trastuzumab is associated now with other anti-HER2 therapies like lapatinib or pertuzumab, the latter being much more easy to use in combination with chemotherapy. …”
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1405“…CONCLUSION: It is concluded that patients with group 2 breast cancer were younger post-menopausal women, with tumors moderately differentiated, HER-2/neu score 0 or 1+ and with lower Ki-67 proliferation rate.…”
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1406“…HER2 overexpression and anti-HER2 agents represent probably the best story of success of individualized therapy in breast cancer. …”
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1407“…Overexpression of human epidermal growth factor receptor (HER-2) occurs in 20–30% of breast cancers and confers survival and proliferative advantages on the tumour cells making HER-2 an ideal therapeutic target for drugs like Herceptin. …”
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1408por Ma, Juan, Han, Huamin, Liu, Deruo, li, Wei, Feng, Hongxiang, Xue, Xin, Wu, Xiaoran, Niu, Ge, Zhang, Ge, Zhao, Yunfeng, Liu, Changzhen, Tao, Hua, Gao, BinEnlace del recurso
Publicado 2013
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1409por Kumai, T, Matsuda, Y, Oikawa, K, Aoki, N, Kimura, S, Harabuchi, Y, Celis, E, Kobayashi, H“…In this study, we report human epidermal receptor (HER) family epitopes that induced CD4 T-cell responses to HNSCC. …”
Publicado 2013
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1410Immunohistochemiluminescence Detection: A Quantitative Tool in Breast Cancer HER-2 Status Evaluationpor Rêgo, Moacyr Jesus Barreto de Melo, Cordeiro, Marina Ferraz, Cavalcanti, Carmelita de Lima Bezerra, de Carvalho Junior, Luiz Bezerra, Beltrão, Eduardo Isidoro Carneiro“…This study presents an immunohistochemiluminescence method to quantify Her-2 in breast cancer. Anti-Her-2 antibody was conjugated to acridinium ester (AE) and used to evaluate/quantify Her-2 status in breast Invasive Ductal Carcinoma (IDC, n = 50) comparing with traditional immunohistochemistry. …”
Publicado 2013
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1412por Zhang, Congcong, Burger, Michael, Schönfeld, Kurt, Genβler, Sabrina, Sahm, Christiane, Naundorf, Sonja, Odendahl, Marcus, Nowakowska, Paulina, Tonn, Torsten, Grez, Manuel, Steinbach, Joachim P, Wels, Winfried SEnlace del recurso
Publicado 2013
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1413por Sawaki, Masataka“…Anti-HER2 agents, such as trastuzumab, lapatinib, trastuzumab emtansine (T-DM1), and pertuzumab, are standard agents in the treatment of breast cancer overexpressing the human epidermal growth factor receptor 2 (HER2). …”
Publicado 2014
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1414por D'Huyvetter, Matthias, Vincke, Cécile, Xavier, Catarina, Aerts, An, Impens, Nathalie, Baatout, Sarah, De Raeve, Hendrik, Muyldermans, Serge, Caveliers, Vicky, Devoogdt, Nick, Lahoutte, Tony“…Most importantly, nanobody-based targeted radionuclide therapy in mice bearing small estiblashed HER2(pos) tumors led to an almost complete blockade of tumor growth and a significant difference in event-free survival between the treated and the control groups (P < 0.0001). …”
Publicado 2014
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1415por Park, So Yeon, Seo, An Na, Jung, Hae Yoen, Gwak, Jae Moon, Jung, Namhee, Cho, Nam-Yun, Kang, Gyeong Hoon“…In IBC, Alu hypomethylation correlated with negative estrogen receptor (ER) status, and LINE-1 hypomethylation was associated with negative ER status, ERBB2 (HER2) amplification and p53 overexpression. Alu and LINE-1 methylation status was significantly different between breast cancer subtypes, and the HER2 enriched subtype had lowest methylation levels. …”
Publicado 2014
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1416“…Since HER2- tumor status testing is the essential part of a successful cancer treatment, the expression and purification of substantial amounts of the extracellular domain (ECD) of HER2 is an important task. …”
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1418“…The aim of this study was to compare quantitative polymerase chain reaction (qPCR) with immunohistochemistry (IHC) for the detection of Her-2 in gastric cancer, and to investigate the correlation between the expression levels of human epidermal growth factor receptor 2 (Her-2) and clinical features. …”
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1419por McDermott, Martina SJ, Browne, Brigid C, Conlon, Neil T, O’Brien, Neil A, Slamon, Dennis J, Henry, Michael, Meleady, Paula, Clynes, Martin, Dowling, Paul, Crown, John, O’Donovan, Norma“…BACKGROUND: HER2 targeted therapies including trastuzumab and more recently lapatinib have significantly improved the prognosis for HER2 positive breast cancer patients. …”
Publicado 2014
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