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  1. 1421
    “…The present study was designed to explore the cross talk between fatty acid synthase (FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 ovarian cancer patients and 15 normal ovarian tissues were enrolled. …”
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    Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer
  2. 1422
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    ErbB2/Her2-specific NK cells for adoptive immunotherapy of glioblastoma
  3. 1423
    “…The aim of this study was to determine the prevalence of elevated serum HER2 ECD levels, the association between these levels and tissue HER2 overexpression, and the potential clinical prognostic value of HER2 ECD in primary invasive breast cancer. …”
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    Preoperative serum HER2 extracellular domain levels in primary invasive breast cancer
  4. 1424
    “…Breast cancer patients who are HER2-positive receive targeted inhibitors to HER2, including trastuzumab and lapatinib. …”
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    Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors
  5. 1425
    “…The aim of the present study was to observe the efficacy of neoadjuvant trastuzumab combined with docetaxel and carboplatin (TCH), and docetaxel, epirubicin and cyclophosphamide (TEC) chemotherapy in human epidermal growth factor receptor-2 (HER-2)-overexpressing breast cancer. The total cohort of 64 cases of HER-2-overexpressing breast cancer patients was divided into two groups according to their treatment preferences: The TCH group, consisting of 39 patients, and the TEC group, consisting of 25 patients. …”
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    Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER-2-overexpressing breast cancer
  6. 1426
    “…Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine therapy in the treatment of breast cancer. …”
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    Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth
  7. 1427
    “…SNP variations in the ErbB2 gene have been identified that alter the protein sequence of the HER2-neu protein, but how these polymorphisms affect prognosis and response to HER2 targeted therapy is unknown. …”
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    Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity
  8. 1428
    “…Previous studies have indicated that Her-2 induction causes a strong decrease in thioredoxin interaction protein (TXNIP) in breast cancer cells. …”
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    TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer
  9. 1429
    “…INTRODUCTION: We previously demonstrated that HER2/neu-driven mammary carcinogenesis can be prevented by an interleukin-12 (IL-12)-adjuvanted allogeneic HER2/neu-expressing cell vaccine. …”
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    Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis
  10. 1430
    “…Background and study aims: The HER2 status of small endoscopic biopsies is important for predicting the eligibility of patients with metastatic HER2-positive gastric cancer or gastro-esophageal junction (GEJ) cancer for anti-HER2 therapy approved by the U.S. …”
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    Minimum biopsy set for HER2 evaluation in gastric and gastro-esophageal junction cancer
  11. 1431
    “…AIMS: To determine the prevalence and clinicopathological characteristics of BRAF V600E mutation and HER2 exon 20 insertions in Chinese lung adenocarcinoma (ADC) patients. …”
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    Prevalence and Clinicopathological Characteristics of HER2 and BRAF Mutation in Chinese Patients with Lung Adenocarcinoma
  12. 1432
    “…The mRNA level of PAQR3 was negatively correlated with HER2 expression (P < 0.0001) and disease-free survival of the patients (P < 0.0001). …”
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    PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression
  13. 1433
    “…To identify peptides with high affinity and specificity against human epidermal growth factor receptor 2 (HER2), a series of peptides were designed based on the structure of HER2 and its Z(HER2:342) affibody. …”
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    Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors
  14. 1434
    “…Paralleling effects on cell survival, AICAR leads to dose- and time-dependent inhibition of HER2 and EGFR in HER2-amplified breast cancer cells, with activation of AMPK and suppression of HER2/EGFR activity preceding commitment to cell death. …”
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    AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
  15. 1435
    “…Next, we examined the relationship between GPNMB and HER2 in vitro using SK-BR3 and BT-474 (HER2-positive/GPNMB-positive) cells. …”
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    Clinical significance of glycoprotein nonmetastatic B and its association with HER2 in breast cancer
  16. 1436
    por Inoue, Kazushi, Fry, Elizabeth A.
    Publicado 2015
    “…The alternative spliced isoform of HER2 lacking exon 20 (Δ16HER2) has been reported in human BC; this isoform is associated with transforming ability than the wild-type HER2 and recapitulates the phenotypes of endocrine therapy-resistant BC. …”
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    Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer
  17. 1437
    “…Here we screened and identified many miRNAs which are dysregulated by HER2 overexpression. In line with our quantitative PCR analysis data, in silico analysis of microRNA expression profiles of 1302 breast tumors revealed that miR-146a-5p is up-regulated and miR-181d and miR-195-5p are down-regulated in HER2-positive tumors. …”
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    Identification of new miRNA biomarkers associated with HER2-positive breast cancers
  18. 1438
    “…Area under the curve (AUC) comparing predicted odds of hemorrhage (HeRS score) to actual hemorrhage status was 0.701. …”
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    Predicting Hemorrhagic Transformation of Acute Ischemic Stroke: Prospective Validation of the HeRS Score
  19. 1439
    “…In this study, we explored blood transcriptional patterns of patients with two subtypes of HER2 negative breast cancers, with different prognosis and therapeutic outcome. …”
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    Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients
  20. 1440
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    Clinical efficacy and safety of T-DM1 for patients with HER2-positive breast cancer
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